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About me

I am a trained biologist, or more accurate animal physiologist from the Agricultural University in Wageningen (NL). I have a PhD in clinical nutrition from the University of Maastricht (NL). After that I did 2 postdoc fellowships; one at the Endocrine Research Unit at the Mayo Clinic in Rochester, Minnesota (USA) and one at the Department of Medicine at the University of Edinburgh (UK). In January 2000 I joined the currenet research group at Karolinska  Institutet and located at hthe Department of Anesthesiology and Intensive Care at Karolinska Unversity Hospital in Huddinge. I started here as a assistent professor and head of the analytical lab. Presently I am a professor in experimental anesthesiology and intensive care and together with Professor Jan Wernerman run the ICU metabolism research group (see www.icu.metabolism.se).

Education

My teaching activities are mainly at the postgraduate level. I am involved in a local course in researcher and research ethics and my main interest in this course is the researcher ethics; how should be behave us as researchers? Ocassionally I organise a course in Clinical Techniques in the study of Endocrine and Metabolic Disorders; a course that teaches different techniques and approaches to study human subjects and patients.

I am the co-organiser of a International course in Tracer Methodology in Clinical Nutrition and Metabolism. This is an intensive course taking place ones a year in a weekend to teach on the usage of stable isotope labelled metabolites to quantify metabolic fluxes in vivo in humans. For more information look at our website (http://icu-metabolism.se/tracers.html)

Research description

The research me and the research group are involved in is to study the metabolic and nutritional problems of critically ill patients. We mainly perform smaller mechanistic physiological studies, but also perfrom smaller intervention studies to elucidate how interventions actually work. The research group is run by me and Pofessor Jan Wernerman and includes clinical researchers (from students up to consultants), basic researchers (from exchange students to associate professors) technical staff and research nurses. Part of metabolism we focus on are:

  • Why do critically ill patients waste muscle mass and function so fast?
  • Why are gplasma glutamine levels sometime high and sometime low in critically ill patients and how do they handle extra glutamine?
  • How much nutritional protein is beneficial for critically ill patients?
  • What is causing high lactate levels during sepsis and is this a problem?
  • Were does plasma albumin go when we are ill and especially when we are critically ill?
  • Should we control glucose levels in the critically ill and peri-operatively?

Details on projects and links to publications can be found on our research group's website.

Publications

Approximation of Resting Energy Expenditure in Intensive Care Unit Patients Using the SenseWear Bracelet: A Comparison With Indirect Calorimetry
Sundström M, Mehrabi M, Tjäder I, Rooyackers O, Hammarqvist F
JPEN. Journal of parenteral and enteral nutrition 2017;41(6):976-980

A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes
Phillips Be, Kelly Bm, Lilja M, Ponce-gonzález Jg, Brogan Rj, Morris Dl, et al
Frontiers in endocrinology 2017;8():229-

Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men
Gorissen Shm, Burd Na, Kramer If, Van Kranenburg J, Gijsen Ap, Rooyackers O, et al
Clinical nutrition (Edinburgh, Scotland) 2017;36(2):429-437

INFLUENCE OF NUTRIENT INGESTION ON AMINO ACID TRANSPORTERS AND PROTEIN SYNTHESIS IN HUMAN SKELETAL MUSCLE AFTER SPRINT EXERCISE
Rundqvist Hc, Esbjörnsson M, Rooyackers O, Osterlund T, Moberg M, Apró W, et al
Journal of applied physiology (Bethesda, Md. : 1985) 2017;():jap.00244.2017-

Low serum selenium is associated with the severity of organ failure in critically ill children
Broman M, Lindfors M, Norberg Å, Hebert C, Rooyackers O, Wernerman J, et al
Clinical nutrition (Edinburgh, Scotland) 2017;():-

Muscle metabolism
Tardif N, Grip J, Rooyackers O
Current opinion in critical care 2017;23(4):264-268

Omics and cachexia
Twelkmeyer B, Tardif N, Rooyackers O
Current opinion in clinical nutrition and metabolic care 2017;20(3):181-185

Proceedings of the 2016 Clinical Nutrition Week Research Workshop-The Optimal Dose of Protein Provided to Critically Ill Patients
Heyland Dk, Rooyakers O, Mourtzakis M, Stapleton Rd
JPEN. Journal of parenteral and enteral nutrition 2017;41(2):208-216

Repeated quantitative measurements of De Novo synthesis of albumin and fibrinogen
Dumitrescu G, Komaromi A, Rooyackers O, Klaude M, Hebert C, Wernerman J, et al
PloS one 2017;12(3):e0174611-

Validation of a point-of-care instrument for bedside glutamine screening in the intensive care unit
Pettersson L, Rydén S, Smedberg M, Tjäder I, Rooyackers O, Wernerman J
Clinical nutrition (Edinburgh, Scotland) 2017;36(1):186-190

Does feeding induce maximal stimulation of protein balance?
Liebau F, Norberg Å, Rooyackers O
Current opinion in clinical nutrition and metabolic care 2016;19(2):120-4

Improved Muscle Mitochondrial Capacity Following Gastric Bypass Surgery in Obese Subjects
Fernström M, Bakkman L, Loogna P, Rooyackers O, Svensson M, Jakobsson T, et al
Obesity surgery 2016;26(7):1391-7

Leakage of albumin in major abdominal surgery
Norberg Å, Rooyackers O, Segersvärd R, Wernerman J
Critical care (London, England) 2016;20(1):113-

Measuring energy expenditure in the intensive care unit: a comparison of indirect calorimetry by E-sCOVX and Quark RMR with Deltatrac II in mechanically ventilated critically ill patients
Rehal Ms, Fiskaare E, Tjäder I, Norberg Å, Rooyackers O, Wernerman J
Critical care (London, England) 2016;20():54-

Omics/systems biology and cancer cachexia
Gallagher Ij, Jacobi C, Tardif N, Rooyackers O, Fearon K
Seminars in cell & developmental biology 2016;54():92-103

Plasma Glutamine Concentrations in Liver Failure
Helling G, Wahlin S, Smedberg M, Pettersson L, Tjäder I, Norberg Å, et al
PloS one 2016;11(3):e0150440-

Simultaneous assessment of the synthesis rate and transcapillary escape rate of albumin in inflammation and surgery
Komáromi A, Estenberg U, Hammarqvist F, Rooyackers O, Wernerman J, Norberg Å
Critical care (London, England) 2016;20(1):370-

The effect of plasma from septic ICU patients on healthy rat muscle mitochondria
Grip J, Jakobsson T, Tardif N, Rooyackers O
Intensive care medicine experimental 2016;4(1):20-

Albumin Kinetics in Patients Undergoing Major Abdominal Surgery
Norberg Å, Rooyackers O, Segersvärd R, Wernerman J
PloS one 2015;10(8):e0136371-

Effect of initiating enteral protein feeding on whole-body protein turnover in critically ill patients
Liebau F, Wernerman J, Van Loon Lj, Rooyackers O
The American journal of clinical nutrition 2015;101(3):549-57

Lactate kinetics and mitochondrial respiration in skeletal muscle of healthy humans under influence of adrenaline
Grip J, Jakobsson T, Hebert C, Klaude M, Sandström G, Wernerman J, et al
Clinical science (London, England : 1979) 2015;129(4):375-84

Leucine does not affect mechanistic target of rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal muscle following resistance exercise
Apró W, Moberg M, Hamilton Dl, Ekblom B, Rooyackers O, Holmberg Hc, et al
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015;29(10):4358-73

Optimizing the measurement of mitochondrial protein synthesis in human skeletal muscle
Burd Na, Tardif N, Rooyackers O, Van Loon Ljc
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM 2015;40(1):1-9

Plasma glutamine deficiency is associated with multiple organ failure in critically ill children
Ekmark L, Rooyackers O, Wernerman J, Fläring U
Amino acids 2015;47(3):535-42

Protein kinetics in human endotoxaemia and their temporal relation to metabolic, endocrine and proinflammatory cytokine responses
Khan As, Gibson Jm, Carlson Gl, Rooyackers O, New Jp, Soop M
The British journal of surgery 2015;102(7):767-75

Short-term amino acid infusion improves protein balance in critically ill patients
Liebau F, Sundstrom M, Van Loon Ljc, Wernerman J, Rooyackers O
CRITICAL CARE 2015;:106-

Whole blood glutathione status and ICU morbidity in critically ill children
Fläring U, Ekmark L, Wernerman J, Rooyackers O
Acta anaesthesiologica Scandinavica 2015;59(10):1311-8

Whole body protein turnover in critically ill patients with multiple organ failure
Rooyackers O, Kouchek-zadeh R, Tjäder I, Norberg Å, Klaude M, Wernerman J
Clinical nutrition (Edinburgh, Scotland) 2015;34(1):95-100

Amino Acid Concentrations in Critically Ill Children Following Cardiac Surgery
Gielen M, Vanhorebeek I, Wouters Pj, Mesotten D, Wernerman J, Van Den Berghe G, et al
PEDIATRIC CRITICAL CARE MEDICINE 2014;15(4):306-13

A tracer bolus method for investigating glutamine kinetics in humans
Mori M, Smedberg M, Klaude M, Tjäder I, Norberg A, Rooyackers O, et al
PloS one 2014;9(5):e96601-

Continuous glucose control in the ICU: report of a 2013 round table meeting
Wernerman J, Desaive T, Finfer S, Foubert L, Furnary A, Holzinger U, et al
Critical care (London, England) 2014;18(3):226-

Endogenous glutamine production in critically ill patients: the effect of exogenous glutamine supplementation
Mori M, Rooyackers O, Smedberg M, Tjäder I, Norberg A, Wernerman J
Critical care (London, England) 2014;18(2):R72-

Plasma glutamine concentration after intensive care unit discharge: an observational study
Smedberg M, Grass Jn, Pettersson L, Norberg Å, Rooyackers O, Wernerman J
Critical care (London, England) 2014;18(6):677-

Upper-body obese women are resistant to postprandial stimulation of protein synthesis
Liebau F, Jensen Md, Nair Ks, Rooyackers O
Clinical nutrition (Edinburgh, Scotland) 2014;33(5):802-7

Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients
Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O
The American journal of clinical nutrition 2013;98(6):1485-92

Continuous glucose monitoring by intravenous microdialysis: influence of membrane length and dialysis flow rate
Rooyackers O, Blixt C, Mattsson P, Wernerman J
Acta anaesthesiologica Scandinavica 2013;57(2):214-9

Continuous on-line glucose measurement by microdialysis in a central vein. A pilot study
Blixt C, Rooyackers O, Isaksson B, Wernerman J
CRITICAL CARE 2013;17(3):R87-

Indirect calorimetry in mechanically ventilated patients. A systematic comparison of three instruments
Sundström M, Tjäder I, Rooyackers O, Wernerman J
Clinical nutrition (Edinburgh, Scotland) 2013;32(1):118-21

Nutrient ingestion increased mTOR signaling, but not hVps34 activity in human skeletal muscle after sprint exercise
Rundqvist Hc, Lilja Mr, Rooyackers O, Odrzywol K, Murray Jt, Esbjörnsson M, et al
Physiological reports 2013;1(5):e00076-

Whole body protein kinetics during hypocaloric and normocaloric feeding in critically ill patients
Berg A, Rooyackers O, Bellander Bm, Wernerman J
CRITICAL CARE 2013;17(4):R158-

Glutamine and glutathione at ICU admission in relation to outcome
Rodas Pc, Rooyackers O, Hebert C, Norberg A, Wernerman J
CLINICAL SCIENCE 2012;122(11-12):591-7

Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment
Andersson A, Rundgren M, Kalman S, Rooyackers O, Brattstrom O, Oldner A, et al
BRITISH JOURNAL OF ANAESTHESIA 2012;108(2):254-61

Pharmacologically Dosed Oral Glutamine Reduces Myocardial Injury in Patients Undergoing Cardiac Surgery: A Randomized Pilot Feasibility Trial
Sufit A, Weitzel Lb, Hamiel C, Queensland K, Dauber I, Rooyackers O, et al
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION 2012;36(5):556-61

Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis
Klaude M, Mori M, Tjader I, Gustafsson T, Wernerman J, Rooyackers O
CLINICAL SCIENCE 2012;122(3-4):133-42

Reduction in plasma leucine after sprint exercise is greater in males than in females
Esbjornsson M, Rooyackers O, Norman B, Rundqvist Hc, Nowak J, Bulow J, et al
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS 2012;22(3):399-409

Sprint exercise enhances skeletal muscle p70S6k phosphorylation and more so in women than in men
Esbjornsson M, Rundqvist Hc, Mascher H, Osterlund T, Rooyackers O, Blomstrand E, et al
ACTA PHYSIOLOGICA 2012;205(3):411-22

The effect of perioperative glucose control on postoperative insulin resistance
Blixt C, Ahlstedt C, Ljungqvist O, Isaksson B, Kalman S, Rooyackers O
Clinical nutrition (Edinburgh, Scotland) 2012;31(5):676-81

Enhanced rates of muscle protein synthesis and elevated mTOR signalling following endurance exercise in human subjects
Mascher H, Ekblom B, Rooyackers O, Blomstrand E
ACTA PHYSIOLOGICA 2011;202(2):175-84

Continuous glucose monitoring by intravenous microdialysis
Rooyackers O, Blixt C, Mattsson P, Wernerman J
ACTA ANAESTHESIOLOGICA SCANDINAVICA 2010;54(7):841-7

Protein metabolism in leg muscle following an endotoxin injection in healthy volunteers
Vesali Rf, Cibicek N, Jakobsson T, Klaude M, Wernerman J, Rooyackers O
CLINICAL SCIENCE 2010;118(5-6):421-7

Reduced Respiratory Capacity in Muscle Mitochondria of Obese Subjects
Bakkman L, Fernstrom M, Loogna P, Rooyackers O, Brandt L, Lagerros Yt
OBESITY FACTS 2010;3(6):371-5

Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia
Stephens Na, Gallagher Ij, Rooyackers O, Skipworth Rj, Tan Bh, Marstrand T, et al
Genome medicine 2010;2(1):1-

Circulating and muscle glutathione turnover in human endotoxaemia
Flaring Ub, Hebert C, Wernerman J, Hammarqvist F, Rooyackers Oe
CLINICAL SCIENCE 2009;117(9-10):313-9

Glutathione and amino acid concentrations in human liver during short warm ischaemia and reperfusion: a pilot study
Westman B, Thorne A, Rooyackers O, Fredriksson K, Wernerman J, Hammarqvist F
CLINICAL SCIENCE 2009;117(9-10):339-44

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide
Diczfalusy U, Olofsson Ke, Carlsson Am, Gong M, Golenbock Dt, Rooyackers O, et al
JOURNAL OF LIPID RESEARCH 2009;50(11):2258-64

Muscle mitochondrial activity increases rapidly after an endotoxin challenge in human volunteers
Fredriksson K, Flaring U, Guillet C, Wernerman J, Rooyackers O
ACTA ANAESTHESIOLOGICA SCANDINAVICA 2009;53(3):299-304

Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course
Ahlbeck K, Fredriksson K, Rooyackers O, Maback G, Remahl S, Ansved T, et al
ACTA ANAESTHESIOLOGICA SCANDINAVICA 2009;53(6):717-23

Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance
Vollaard Nbj, Constantin-teodosiu D, Fredriksson K, Rooyackers O, Jansson E, Greenhaff Pl, et al
JOURNAL OF APPLIED PHYSIOLOGY 2009;106(5):1479-86

Dysregulation of Mitochondrial Dynamics and the Muscle Transcriptome in ICU Patients Suffering from Sepsis Induced Multiple Organ Failure
Fredriksson K, Tjader I, Keller P, Petrovic N, Ahlman B, Scheele C, et al
PLOS ONE 2008;3(11):e3686-

The pattern of amino acid exchange across the brain is unaffected by intravenous glutamine supplementation in head trauma patients
Berg A, Bellander Bm, Wanecek M, Norberg A, Ungerstedt U, Rooyackers O, et al
CLINICAL NUTRITION 2008;27(6):816-21

Effect of extended cold ischemia time on glucose metabolism in liver grafts: experimental study in pigs
Gillispie A, Rooyackers O, Wernerman J, Nowak G
JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY 2007;14(2):183-8

Enhanced In vivo protein synthesis in circulating immune cells of ICU patients
Januszkiewicz A, Klaude M, Lore K, Andersson J, Ringden O, Rooyackers O, et al
JOURNAL OF CLINICAL IMMUNOLOGY 2007;27(6):589-97

Glutamine kinetics during intravenous glutamine supplementation in ICU patients on continuous renal replacement therapy
Berg A, Norberg A, Martling Cr, Gamrin L, Rooyackers O, Wernerman J
INTENSIVE CARE MEDICINE 2007;33(4):660-6

Knee replacement surgery as a human clinical model of the effects of ischaemia/reperfusion upon skeletal muscle
Westman B, Weidenhielm L, Rooyackers O, Fredriksson K, Wernerman J, Hammarqvist F
CLINICAL SCIENCE 2007;113(7-8):313-8

Mitochondrial function in sepsis: Respiratory versus leg muscle
Fredriksson K, Rooyackers O
CRITICAL CARE MEDICINE 2007;35(9):S449-53

Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis
Klaude M, Fredriksson K, Tjader I, Hammarqvist F, Ahlman B, Rooyachers O, et al
CLINICAL SCIENCE 2007;112(9-10):499-506

Randomized clinical trial of the effect of preoperative oral carbohydrate treatment on postoperative whole-body protein and glucose kinetics
Svanfeldt M, Thorell' A, Hausel J, Soop M, Rooyackers O, Nygren J, et al
BRITISH JOURNAL OF SURGERY 2007;94(11):1342-50

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
Scheele C, Petrovic N, Faghihi Ma, Lassmann T, Fredriksson K, Rooyackers O, et al
BMC GENOMICS 2007;:74-

Adipose tissue extracts plasma ammonia after sprint exercise in women and men
Esbjornsson M, Bulow J, Norman B, Simonsen L, Nowak J, Rooyackers O, et al
JOURNAL OF APPLIED PHYSIOLOGY 2006;101(6):1576-80

Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure
Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2006;291(5):E1044-50

Intravenous glutamine supplementation to head trauma patients leaves cerebral glutamate concentration unaffected
Berg A, Bellander Bm, Wanecek M, Gamrin L, Elving A, Rooyackers O, et al
INTENSIVE CARE MEDICINE 2006;32(11):1741-6

Synthesis rates of total liver protein and albumin are both increased in patients with an acute inflammatory response
Barle H, Hammarqvist F, Westman B, Klaude M, Rooyackers O, Garlick Pj, et al
CLINICAL SCIENCE 2006;110(1):93-9

Amino acid metabolism in leg muscle after an endotoxin injection in healthy volunteers
Vesali Rf, Klaude M, Rooyackers O, Wernerman J
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2005;288(2):E360-4

Determination of in vivo protein synthesis in human palatine tonsil
Januszkiewicz A, Klaude M, Lore K, Andersson J, Ringden O, Rooyackers O, et al
CLINICAL SCIENCE 2005;108(2):179-84

Effect of prolonged mechanical ventilation on diaphragm muscle mitochondria in piglets
Fredriksson K, Radell P, Eriksson Li, Hultenby K, Rooyackers O
ACTA ANAESTHESIOLOGICA SCANDINAVICA 2005;49(8):1101-7

Elimination kinetics of L-alanyl-L-glutamine in ICU patients
Berg A, Rooyackers O, Norberg A, Wernerman J
AMINO ACIDS 2005;29(3):221-8

Temporal changes in whole-blood and plasma glutathione in ICU patients with multiple organ failure
Flaring Ub, Rooyackers Oe, Hebert C, Bratel T, Hammarqvist F, Wernerman J
INTENSIVE CARE MEDICINE 2005;31(8):1072-8

Contractile protein breakdown in human leg skeletal muscle as estimated by [H-2(3)]-3-methylhistidine: A new method
Vesali Rf, Klaude M, Thunblad L, Rooyackers Oe, Wernerman J
METABOLISM-CLINICAL AND EXPERIMENTAL 2004;53(8):1076-80

Effects on skeletal muscle of intravenous glutamine supplementation to ICU patients
Tjader I, Rooyackers O, Forsberg Am, Vesali Rf, Garlick Pj, Wernerman J
INTENSIVE CARE MEDICINE 2004;30(2):266-75

Impact of surgical trauma on human skeletal muscle protein synthesis
Tjader I, Essen P, Garlick Pj, Mcnurlan Ma, Rooyackers O, Wernerman J
CLINICAL SCIENCE 2004;107(6):601-7

Insulin stimulated glucose disposal in peripheral tissues studied with microdialysis and stable isotope tracers
Rooyackers O, Myrenfors P, Nygren J, Thorell A, Ljungqvist O
CLINICAL NUTRITION 2004;23(4):743-52

Intensive insulin treatment in critically ill trauma patients normalizes glucose by reducing endogenous glucose production
Thorell A, Rooyackers O, Myrenfors P, Soop M, Nygren J, Ljungqvist Oh
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2004;89(11):5382-6

Microdialysis methods for measuring human metabolism
Rooyackers O, Thorell A, Nygren J, Ljungqvist O
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE 2004;7(5):515-21

Effects of the 11 beta-hydroxysteroid dehydrogrenase inhibitor carbenoxolone on insulin sensitivity in men with type 2 diabetes
Andrews Rc, Rooyackers O, Walker Br
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2003;88(1):285-91

Glutamine attenuates post-traumatic glutathione depletion in human muscle
Flaring Ub, Rooyackers Oe, Wernerman J, Hammarqvist F
CLINICAL SCIENCE 2003;104(3):275-82

Reduced oxidative power but unchanged antioxidative capacity in skeletal muscle from aged humans
Tonkonogi M, Fernstrom M, Walsh B, Ji Ll, Rooyackers O, Hammarqvist F, et al
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2003;446(2):261-9

Temporal changes in muscle glutathione in ICU patients
Flaring Ub, Rooyackers Oe, Wernerman J, Hammarqvist F
INTENSIVE CARE MEDICINE 2003;29(12):2193-8

Glutathione synthetase deficiency: Is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione?
Ristoff E, Hebert C, Njalsson R, Norgren S, Rooyackers O, Larsson A
JOURNAL OF INHERITED METABOLIC DISEASE 2002;25(7):577-84

Longitudinal pattern of glutamine/glutamate balance across the leg in long-stay intensive care unit patients
Vesali Rf, Klaude M, Rooyackers Oe, Tjader I, Barle H, Wernerman J
CLINICAL NUTRITION 2002;21(6):505-14

Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes
Musi N, Hirshman Mf, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, et al
DIABETES 2002;51(7):2074-81

Different effects of corticosteroid-induced muscle wasting compared with undernutrition on rat diaphragm energy metabolism
Koerts-de Lang E, Schols Amwj, Rooyackers Oe, Gayan-ramirez G, Decramer M, Wouters Efm
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;82(5-6):493-8

Effect of oral glucose on leucine turnover in human subjects at rest and during exercise at two levels of dietary protein
Bowtell Jl, Leese Gp, Smith K, Watt Pw, Nevill A, Rooyackers O, et al
JOURNAL OF PHYSIOLOGY-LONDON 2000;525(1):271-81

Modulation of whole body protein metabolism, during and, after exercise, by variation of dietary protein
Bowtell Jl, Leese Gp, Smith K, Watt Pw, Nevill A, Rooyackers O, et al
JOURNAL OF APPLIED PHYSIOLOGY 1998;85(5):1744-52

Contraction failure of skeletal muscle of rats recovering from critical illness
Rooyackers Oe, Hesselink Mkc, Wagenmakers Ajm
CLINICAL SCIENCE 1997;92(2):189-95

Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans
Balagopal P, Rooyackers Oe, Adey Db, Ades Pa, Nair Ks
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 1997;273(4):E790-800

Hormonal regulation of human muscle protein metabolism
Rooyackers Oe, Nair Ks
ANNUAL REVIEW OF NUTRITION 1997;:457-85

Measurement of synthesis rates of specific muscle proteins using needle biopsy samples
Rooyackers Oe, Balagopal P, Nair Ks
MUSCLE & NERVE 1997;:S93-6

Derangement in aerobic and anaerobic energy metabolism in skeletal muscle of critically ill and recovering rats
Rooyackers Oe, Gijsen Ap, Saris Whm, Soeters Pb, Wagenmakers Ajm
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1996;1315(1):55-60

Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
Rooyackers Oe, Adey Db, Ades Pa, Nair Ks
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(26):15364-9

Mitochondrial protein content and in vivo synthesis rates in skeletal muscle from critically ill rats
Rooyackers Oe, Kersten Ah, Wagenmakers Ajm
CLINICAL SCIENCE 1996;91(4):475-81

Tracer kinetics are of limited value to measure in vivo protein synthesis and degradation rates in muscle of anesthetized rats
Rooyackers Oe, Wagenmakers Ajm
METABOLISM-CLINICAL AND EXPERIMENTAL 1996;45(10):1279-83

EFFECT OF AN ENTERALLY ADMINISTERED GLUTAMINE-RICH PROTEIN ON THE CATABOLIC RESPONSE TO A ZYMOSAN CHALLENGE IN RATS
Rooyackers Oe, Soeters Pb, Saris Whm, Wagenmakers Ajm
CLINICAL NUTRITION 1995;14(2):105-15

PROLONGED ACTIVATION OF THE BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX IN MUSCLE OF ZYMOSAN TREATED RATS
Rooyackers Oe, Senden Jmg, Soeters Pb, Saris Whm, Wagenmakers Ajm
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 1995;25(8):548-52

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