Niklas Björkström
Professor/Specialist Physician
| Docent
E-mail: niklas.bjorkstrom@ki.se
Telephone: +46852482912
Visiting address: Alfred Nobels allé 8, plan 7, 14152 Huddinge
Postal address: H7 Medicin, Huddinge, H7 CIM Björkström, 171 77 Stockholm
About me
- Niklas Björkström is a research group leader at Center for Infectious Medicine, Karolinska Institutet and a physician at Clinical Microbiology, Karolinska University Hospital. Björkström earned his medical and doctoral degrees at Karolinska Institutet. He performed postdoctoral studies at the National Institutes of Health, Bethesda, USA, and have been a principal investigator at Karolinska Institutet since 2014. Björkström has authored >
- 100 articles within the fields of immunology, infection, and cancer. The main focus of his research is to understand the biology of human tissue-resident lymphocytes in health and disease with a particular focus on liver and bile duct disorders as well as on pregnancy. His research group is specialized in advanced immunological methods for analysis of rare populations of human immune cells.
Education
2016, Associate Professor in Immunology, Karolinska Institutet, Sweden
2013, Swedish Medical License, Karolinska University Hospital, Sweden
2011-2012, Postdoctoral Fellow, VRC, NIH, USA
2011, PhD, Karolinska Institutet, Sweden
2010, MD, Karolinska Institutet, Sweden
Academic honours, awards and prizes
2021 NovoNordisk Foundation Emerging Investigator
2020 Anders Jahre Award for Young Researchers
2020 ERC Starting Grant
2016 SSF Future Research Leader Award
2016 Wallenberg Academy Fellow Award
2015 United European Gastroenterology (UEG) Rising Star
2014 NovoNordisk Young Excellence Award for Young Researchers
2013 SSMFs Stora Anslag
2012 Sven Gards award for best thesis within virology at KI
2011 Jonas Söderquist scholarship for a young talented virology researcher
2010 Asklepios award for best publication 2010 by a young researcher
2008 Poster award, 38th Annual meeting of the SSI
2008 ISAC student award recipient
2006 The McKinsey Sweden award
Research
- Our research group at the Department of medicine Huddinge, performs translational immunological research studying tissue-resident natural killer cells in the human liver and uterus.
A key focus of the group is to gain insights into the basic biology of tissue resident NK cells in liver and uterus. Through unique collaborations with clinical units at the Karolinska University Hospital, we receive a high number of tissue samples. With respect to the uterus, key questions of interest include detailed characterization of the uterine NK cell KIR receptor repertoires, functional studies of uterine tissue resident NK cells, as well as trying to elucidate the ontogeny of uterine NK cells. In the liver we have a specific focus on human tissue-resident CD49a+ intrahepatic NK cells and study their phenotype, function, development, and role during liver diseases.
Moreover, we have an interest in the role of natural killer (NK) cells in the pathogenesis of liver diseases such as primary sclerosing cholangitis, steatohepatitis (NASH), and hepatitis virus infections (HBV, HCV, HDV). These diseases strongly predispose for tumor development in the human liver and we are also performing tumorimmunological studies evaluating the capacity of NK cells to recognize hepatocellular carcinoma and cholagiocarcinoma. Outside the liver, we also have an interest in NK-cell function during hemorrhagic fever virus infections.
Our studies include phenotypic and functional assessments of NK cells with a focus on differentiation, education, and functional and transcriptional regulation. We work with high-dimensional 22-parameter flow cytometry, CyTOF, microscopy techniques, and new tools for visualization and analysis of highly complex flow cytometry data including SPADE, SNE, and Citrus. We function in close collaboration with other groups at Karolinska Institutet, including groups at the Center for Infectious Medicine (CIM). We participate in Karolinska Institutet - Hannover Medical School exchange program, in the International PSC Study Group network, and have multiple national and international collaborations.
Articles
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Article: GASTROENTEROLOGY. 2024;166(4):667-679
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Article: JOURNAL OF INFECTIOUS DISEASES. 2024;:jiae036
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Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(2):e13336
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Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
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Article: SCIENTIFIC REPORTS. 2023;13(1):22590
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Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687
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Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2023;114(5):507-512
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Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;90(2):e13738
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Article: NATURE METABOLISM. 2023;5(7):1188-1203
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Article: RESPIRATORY RESEARCH. 2023;24(1):62
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2023;53(2):e2249990
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Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1130370
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Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1186097
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Article: FRONTIERS IN ONCOLOGY. 2023;13:1169537
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Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(3):441-452
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Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
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Article: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. 2022;10(5):465-476
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Article: HEPATOLOGY. 2022;75(5):1154-1168
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Article: AMERICAN JOURNAL OF PATHOLOGY. 2022;192(4):629-641
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Article: CELL REPORTS. 2022;38(10):110503
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):472-483
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
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Article: MOLECULAR MEDICINE. 2022;28(1):20
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Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:856530
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Article: LAKARTIDNINGEN. 2021;118:21163
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
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Article: LIVER INTERNATIONAL. 2021;41(9):2046-2058
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Article: CURRENT OPINION IN VIROLOGY. 2021;49:176-182
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Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107
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Article: CELLS. 2021;10(6):1369
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Article: CELL REPORTS MEDICINE. 2021;2(3):100220
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Article: MUCOSAL IMMUNOLOGY. 2021;14(2):357-365
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Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(582):eabb0036
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Article: SCIENCE IMMUNOLOGY. 2021;6(56):eabb7800
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
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Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2021;100(2):339-346
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Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
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Article: BMC GASTROENTEROLOGY. 2020;20(1):428
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Article: CELL. 2020;183(7):1946-1961.e15
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Article: GUT. 2020;69(12):2203-2213
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Article: HEPATOLOGY. 2020;72(4):1378-1393
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Article: CELL. 2020;183(1):158-168.e14
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Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
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Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
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Article: NATURE COMMUNICATIONS. 2020;11(1):2049
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Article: SCIENTIFIC REPORTS. 2020;10(1):2081
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Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:71-82
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Article: METHODS IN MOLECULAR BIOLOGY. 2020;2164:55-63
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Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224
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Article: JOURNAL OF IMMUNOLOGY. 2019;203(8):2210-2221
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Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9
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Article: NATURE COMMUNICATIONS. 2019;10(1):3897
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Article: CELL REPORTS. 2019;28(8):2124-2139.e6
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Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312
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Article: LIVER INTERNATIONAL. 2019;39(6):1098-1108
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Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(5):510-523
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Article: NATURE METABOLISM. 2019;1(4):445-459
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Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2692
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Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1255
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(12):1997-2004
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(9):1456-1469
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Article: JOURNAL OF HEPATOLOGY. 2018;69(3):584-593
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Article: GUT. 2018;67(8):1517-1524
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(8):1329-1335
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Article: NATURE COMMUNICATIONS. 2018;9(1):2275
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Article: JOURNAL OF INFECTIOUS DISEASES. 2018;217(10):1656-1666
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Article: JOURNAL OF HEPATOLOGY. 2018;68(3):421-430
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Article: PLOS GENETICS. 2018;14(1):e1007163
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294
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Article: PLOS PATHOGENS. 2017;13(6):e1006462
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Article: MUCOSAL IMMUNOLOGY. 2017;10(2):322-331
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Article: FRONTIERS IN IMMUNOLOGY. 2017;8:765
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Article: FRONTIERS IN IMMUNOLOGY. 2017;8:525
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(9):2204-2210
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Article: ENDOSCOPY INTERNATIONAL OPEN. 2016;4(8):E901-E911
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Article: NATURE MEDICINE. 2016;22(6):614-623
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(7):E864-E873
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Article: HEPATOLOGY. 2015;62(4):1249-1259
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Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471
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Article: PLOS PATHOGENS. 2014;10(11):e1004521
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Article: CLINICAL INFECTIOUS DISEASES. 2014;59(8):1130-1132
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Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(9):1362-1373
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Article: VACCINE. 2014;32(6):717-724
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Article: PLOS ONE. 2014;9(8):e105375
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901
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Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2013;48(6):719-728
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Article: PLOS PATHOGENS. 2013;9(3):e1003272
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Article: BLOOD. 2012;120(17):3455-3465
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Article: JOURNAL OF INFECTIOUS DISEASES. 2012;205(9):1351-1362
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(2):447-457
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Article: JOURNAL OF VIROLOGY. 2011;85(19):10252-10260
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Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923
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Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21
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Article: PLOS ONE. 2011;6(11):e27664
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Article: BLOOD. 2010;116(19):3853-3864
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Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500
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Article: GASTROENTEROLOGY. 2010;138(5):1885-1U68
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Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(2):378-387
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Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
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Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:335-352
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Article: JOURNAL OF IMMUNOLOGY. 2009;183(10):6612-6618
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Article: IMMUNOTHERAPY. 2009;1(5):753-764
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Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019
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Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228
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Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
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Article: CANCER RESEARCH. 2007;67(3):1317-1325
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Article: ARTHRITIS RESEARCH & THERAPY. 2007;9(5):r87
- Show more
All other publications
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Review: JOURNAL OF HEPATOLOGY. 2022;77(6):1657-1669
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Letter: LANCET INFECTIOUS DISEASES. 2022;22(11):1538-1540
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Letter: LANCET INFECTIOUS DISEASES. 2022;22(10):1421-1422
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Review: NATURE REVIEWS IMMUNOLOGY. 2022;22(2):112-123
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Corrigendum: NATURE METABOLISM. 2021;3(2):287
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Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2020;31(1):3-12
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Review: FRONTIERS IN IMMUNOLOGY. 2020;11:571166
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Review: LIVER INTERNATIONAL. 2019;39 Suppl 1(Suppl 1):63-78
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Corrigendum: NATURE METABOLISM. 2019;1(4):497
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Letter: JOURNAL OF INFECTIOUS DISEASES. 2018;218(11):1853-1854
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Other: CELL STRESS. 2018;2(8):216-218
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Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
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Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320
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Review: CLINICAL IMMUNOLOGY. 2016;163:52-59
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Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2015;45(7):2154-2157
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Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196
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Review: IMMUNOLOGY. 2013;139(4):416-427
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Thesis / dissertation: 2011
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Review: TRENDS IN IMMUNOLOGY. 2010;31(11):401-406
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Published conference paper: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2008;57(10):1541-1552
Employments
- Professor/Specialist Physician, Department of Medicine, Huddinge, Karolinska Institutet, 2023-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2011
- University Medical Degree, Karolinska Institutet, 2010