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2010, MD, Karolinska Institutet

2011, PhD, Karolinska Institutet

2011-2012, Postdoctoral Fellow, VRC, NIH

2013, Swedish Medical License,

2014-, Assistant Professor, CIM, Department of Medicine Huddinge, Karolinska Institutet

Research description

Our group performs translational immunological research studying tissue-resident natural killer cells in the human liver and uterus.

A key focus of the group is to gain insights into the basic biology of tissue resident NK cells in liver and uterus. Through unique collaborations with clinical units at the Karolinska University Hospital, we receive a high number of tissue samples. With respect to the uterus, key questions of interest include detailed characterization of the uterine NK cell KIR receptor repertoires, functional studies of uterine tissue resident NK cells, as well as trying to elucidate the ontogeny of uterine NK cells. In the liver we have a specific focus on human tissue-resident CD49a+ intrahepatic NK cells and study their phenotype, function, development, and role during liver diseases.

Moreover, we have an interest in the role of natural killer (NK) cells in the pathogenesis of liver diseases such as primary sclerosing cholangitis, steatohepatitis (NASH), and hepatitis virus infections (HBV, HCV, HDV). These diseases strongly predispose for tumor development in the human liver and we are also performing tumorimmunological studies evaluating the capacity of NK cells to recognize hepatocellular carcinoma and cholagiocarcinoma. Outside the liver, we also have an interest in NK-cell function during hemorrhagic fever virus infections.

Our studies include phenotypic and functional assessments of NK cells with a focus on differentiation, education, and functional and transcriptional regulation. We work with high-dimensional 22-parameter flow cytometry, CyTOF, microscopy techniques, and new tools for visualization and analysis of highly complex flow cytometry data including SPADE, SNE, and Citrus.

We function in close collaboration with other groups at Karolinska Institutet, including groups at the Center for Infectious Medicine. We participate in Karolinska Institutet - Hannover Medical School exchange program, in the International PSC Study Group network, and have multiple national and international collaborations.

Academic honors, awards and prizes

2014                        United European Gastroenterology (UEG) Rising Star

2014                        NovoNordisk Young Excellence Award for Young Researchers

2013                        SSMFs Stora Anslag

2012                        Sven Gards award for best thesis within virology at KI

2011                        Jonas Söderquist scholarship for a young talented virology researcher

2010                        Asklepios award for best publication 2010 by a young researcher

2008                        Poster award, 38th Annual meeting of the SSI

2008                        ISAC student award recipient

2006                        The McKinsey Sweden award


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