Mattias Carlström is an Associate Professor and group leader for Reactive oxygen species and nitric oxide signaling in renal and cardiovascular function at the Department of Physiology and Pharmacology.
Development of salt-sensitive hypertension in hydronephrosis.
Acta Universitatis Upsaliensis; Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 324; 2008 (ISBN 978-91-554-7137-8)
Emerging evidence suggests that renal oxidative stress and nitric oxide (NO) deficiency is linked to cardiovascular disease and diabetic complications. Mechanisms are not clear, but exaggerated NADPH oxidase-derived superoxide production and NO deficiency may impair renal autoregulation. Using a translational design, our projects aim to characterize the mechanisms for superoxide and NO formation, interaction and influence on renal, cardiovascular and metabolic functions in health and disease.