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Martin Rottenberg

Professor

Visiting address : Nobels Väg 16 171 77 Stockholm, Sweden
Postal address : Department of Microbiology, Tumor and Cell Biology (MTC), C1, Martin Rottenberg group, Box 280 171 77 Stockholm, Sweden
Delivery address : Nobels Väg 16 171 77 Stockholm, Sweden

Publications

Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3
Ashenafi S, Aderaye G, Bekele A, Zewdie M, Aseffa G, Hoang At, et al
Clinical immunology (Orlando, Fla.) 2014;151(2):84-99

Role of the Listeria monocytogenes 2-Cys peroxiredoxin homologue in protection against oxidative and nitrosative stress and in virulence
Dons Le, Mosa A, Rottenberg Me, Rosenkrantz Jt, Kristensson K, Olsen Je
PATHOGENS AND DISEASE 2014;70(1):70-4

T cells modulate Epstein-Barr virus latency phenotypes during infection of humanized mice
Heuts F, Rottenberg Me, Salamon D, Rasul E, Adori M, Klein G, et al
Journal of virology 2014;88(6):3235-45

CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria
Heuts F, Gavier-widén D, Carow B, Juarez J, Wigzell H, Rottenberg Me
Proceedings of the National Academy of Sciences of the United States of America 2013;110(16):6482-7

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis
Carow B, Reuschl Ak, Gavier-widén D, Jenkins Bj, Ernst M, Yoshimura A, et al
PLoS pathogens 2013;9(7):e1003442-

Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase of Trypanosoma brucei
Lu J, Vodnala Sk, Gustavsson Al, Gustafsson Tn, Sjoberg B, Johansson Ha, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2013;288(38):27456-68

Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis
Masood Ki, Rottenberg Me, Salahuddin N, Irfan M, Rao N, Carow B, et al
BMC INFECTIOUS DISEASES 2013;:13-

In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis
Vodnala Sk, Lundbäck T, Sjöberg B, Svensson R, Rottenberg Me, Hammarström Lg
Antimicrobial agents and chemotherapy 2013;57(2):1012-8

Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis
Vodnala Sk, Lundbäck T, Yeheskieli E, Sjöberg B, Gustavsson Al, Svensson R, et al
Journal of medicinal chemistry 2013;56(24):9861-73

Distinct Toll-like Receptor Signals Regulate Cerebral Parasite Load and Interferon alpha/beta and Tumor Necrosis Factor alpha-Dependent T-Cell Infiltration in the Brains of Trypanosoma brucei-Infected Mice
Amin Dn, Vodnala Sk, Masocha W, Sun B, Kristensson K, Rottenberg Me
JOURNAL OF INFECTIOUS DISEASES 2012;205(2):320-32

LPS Regulates SOCS2 Transcription in a Type I Interferon Dependent Autocrine-Paracrine Loop
Hu J, Lou Dh, Carow B, Winerdal Me, Rottenberg M, Wikstrom Ac, et al
PLOS ONE 2012;7(1):e30166-

Mycobacterium tuberculosis Sonicate-Induced IFN?, CXCL10 and IL10 can Differentiate Severity in Tuberculosis
Hasan Z, Rao N, Salahuddin N, Islam M, Ashraf M, Rottenberg Me, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2012;75(2):220-6

SOCS1 gene expression is increased in severe pulmonary tuberculosis
Masood Ki, Rottenberg Me, Carow B, Rao N, Ashraf M, Hussain R, et al
Scandinavian journal of immunology 2012;76(4):398-404

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
Zadjali F, Santana-farre R, Vesterlund M, Carow B, Mirecki-garrido M, Hernandez-hernandez I, et al
FASEB JOURNAL 2012;26(8):3282-91

Tuberculosis and HIV Co-Infection
Pawlowski A, Jansson M, Skold M, Rottenberg Me, Kallenius G
PLOS PATHOGENS 2012;8(2):e1002464-

Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
Cloete Tt, Johansson Cc, N'da Dd, Vodnala Sk, Rottenberg Me, Breytenbach Jc, et al
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 2011;61(5):317-25

Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-gamma (IFN-gamma)-dependent Manner
Carow B, Ye Xq, Gavier-widen D, Bhuju S, Oehlmann W, Singh M, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2011;286(30):26873-87

Alloreactivity but Failure to Reject Human Islet Transplants by Humanized Balb/c/Rag2(-/-)gc(-/-) Mice
Jacobson S, Heuts F, Juarez J, Hultcrantz M, Korsgren O, Svensson M, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2010;71(2):83-90

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56(dim) NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom Nk, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson Ma, et al
BLOOD 2010;116(19):3853-64

Identification of Stage Biomarkers for Human African Trypanosomiasis
Amin Dn, Ngoyi Dm, Nhkwachi Gm, Palomba M, Rottenberg M, Buscher P, et al
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 2010;82(6):983-90

The ability to enter into an avirulent viable but non-culturable (VBNC) form is widespread among Listeria monocytogenes isolates from salmon, patients and environment
Lindback T, Rottenberg Me, Roche Sm, Rorvik Lm
VETERINARY RESEARCH 2010;41(1):8-

Bioluminescent Imaging of Trypanosoma brucei Shows Preferential Testis Dissemination Which May Hamper Drug Efficacy in Sleeping Sickness
Claes F, Vodnala Sk, Van Reet N, Boucher N, Lunden-miguel H, Baltz T, et al
PLOS NEGLECTED TROPICAL DISEASES 2009;3(7):e486-

Expression and Role of CXCL10 during the Encephalitic Stage of Experimental and Clinical African Trypanosomiasis
Amin Dn, Rottenberg Me, Thomsen Ar, Mumba D, Fenger C, Kristensson K, et al
JOURNAL OF INFECTIOUS DISEASES 2009;200(10):1556-65

Immune signalling via MyD88 is required for macrophage/microglia to control African trypanosomes in the brain early during neuro-invasion
Amin Dn, Kristensson K, Rottenberg M
TROPICAL MEDICINE & INTERNATIONAL HEALTH 2009;:176-176

Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner
Mosa A, Trumstedt C, Eriksson E, Soehnlein O, Heuts F, Janik K, et al
INFECTION AND IMMUNITY 2009;77(7):2908-18

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin
Vodnala Sk, Ferella M, Lunden-miguel H, Betha E, Van Reet N, Amin Dn, et al
PLOS NEGLECTED TROPICAL DISEASES 2009;3(8):e495-

Use of non-invasive bioluminescent imaging to assess mycobacterial dissemination in mice, treatment with bactericidal drugs and protective immunity
Heuts F, Carow B, Wigzell H, Rottenberg Me
MICROBES AND INFECTION 2009;11(14-15):1114-21

Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice
Masocha W, Amin Dn, Kristensson K, Rottenberg Me
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(5):484-91

Neutrophil secretion products pave the way for inflammatory monocytes
Soehnlein O, Zernecke A, Eriksson Ee, Rothfuchs Ag, Pham Ct, Herwald H, et al
BLOOD 2008;112(4):1461-71

SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but hampers effective bacterial clearance
Yang Tb, Stark P, Janik K, Wigzell H, Rottenberg Me
JOURNAL OF IMMUNOLOGY 2008;180(6):4040-9

Suramin and minocycline treatment of experimental African trypanososmiasis at an early stage of parasite brain invasion
Amin Dn, Masocha W, Ngan'dwec K, Rottenberg M, Kristensson K
ACTA TROPICA 2008;106(1):72-4

Axonal transport of listeria monocytogenes and nerve-cell-induced bacterial killing
Dons L, Jin Yx, Kristensson K, Rottenberg Me
JOURNAL OF NEUROSCIENCE RESEARCH 2007;85(12):2529-37

Migration of African trypanosomes across the blood-brain barrier
Masocha W, Rottenberg Me, Kristensson K
PHYSIOLOGY & BEHAVIOR 2007;92(1-2):110-4

Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae
Trumstedt C, Eriksson E, Lundberg Am, Yang Tb, Yan Zq, Wigzell H, et al
JOURNAL OF LEUKOCYTE BIOLOGY 2007;81(6):1591-8

Antimicrobial peptide LL-37 in human atherosclerosis
Edfeldt K, Agerberth B, Rottenberg Me, Gudmundsson Gh, Mandal K, Xu Qb, et al
ATHEROSCLEROSIS SUPPLEMENTS 2006;7(3):407-407

Immunoglobulin A and CD8(+) T-cell mucosal immune defenses protect against intranasal infection with Chlamydia pneumoniae
Rodriguez A, Rottenberg M, Tjarnlund A, Fernandez C
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2006;63(3):177-83

Involvement of the antimicrobial peptide LL-37 in human atherosclerosis
Edfeldt K, Agerberth B, Rottenberg Me, Gudmundsson Gh, Wang Xb, Mandal K, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2006;26(7):1551-7

Minocycline impedes African trypanosome invasion of the brain in a murine model
Masocha W, Rottenberg Me, Kristensson K
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006;50(5):1798-804

Nitric oxide and peroxynitrite have different antiviral effects against hantavirus replication and free mature virions
Klingstrom J, Akerstrom S, Hardestam J, Stoltz M, Simon M, Falk Ki, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2006;36(10):2649-57

Role of nitric oxide during rotavirus infection
Rodriguez-diaz J, Banasaz M, Istrate C, Buesa J, Lundgren O, Espinoza F, et al
JOURNAL OF MEDICAL VIROLOGY 2006;78(7):979-85

Rotavirus infection is not associated with small intestinal fluid secretion in the adult mouse
Kordasti S, Istrate C, Banasaz M, Rottenberg M, Sjovall H, Lundgren O, et al
JOURNAL OF VIROLOGY 2006;80(22):11355-61

STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells
Rothfuchs Ag, Trumstedt C, Mattei F, Schiavoni G, Hidmark A, Wigzell H, et al
JOURNAL OF IMMUNOLOGY 2006;176(11):6982-90

Treatment of African trypanosomiasis with cordycepin and adenosine deaminase inhibitors in a mouse model
Rottenberg Me, Masocha W, Ferella M, Petitto-assis F, Goto H, Kristensson K, et al
JOURNAL OF INFECTIOUS DISEASES 2005;192(9):1658-65

Cerebral vessel laminins and IFN-gamma y define Trypanosoma brucei brucei penetration of the blood-brain barrier
Masocha W, Robertson B, Rottenberg Me, Mhlanga J, Sorokin L, Kristensson K
JOURNAL OF CLINICAL INVESTIGATION 2004;114(5):689-94

Interferon-gamma mediates neuronal killing of intracellular bacteria
Jin Y, Lundkvist G, Dons L, Kristensson K, Rottenberg Me
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2004;60(5):437-48

Intracellular bacterial infection-induced IFN-gamma is critically but not solely dependent on toll-like receptor 4-myeloid differentiation factor 88-IFN-alpha beta-STAT1 signaling
Rothfuchs Ag, Trumstedt C, Wigzell H, Rottenberg Me
JOURNAL OF IMMUNOLOGY 2004;172(10):6345-53

Macrophages, CD4(+) or CD8(+) cells are each sufficient for protection against Chlamydia pneumoniae infection through their ability to secrete IFN-gamma
Rothfuchs Ag, Kreuger Mr, Wigzell H, Rottenberg Me
JOURNAL OF IMMUNOLOGY 2004;172(4):2407-15

Role of flagellin and the two-component CheA/CheY system of Listeria monocytogenes in host cell invasion and virulence
Dons L, Eriksson E, Jin Yx, Rottenberg Me, Kristensson K, Larsen Cn, et al
INFECTION AND IMMUNITY 2004;72(6):3237-44

CD44-regulated intracellular proliferation of Listeria monocytogenes
Eriksson E, Dons L, Rothfuchs Ag, Heldin P, Wigzell H, Rottenberg Me
INFECTION AND IMMUNITY 2003;71(7):4102-11

Cytokine response and outcome of infection depends on the infective dose of parasites in experimental infection by Echinococcus granulosus
Dematteis S, Rottenberg M, Baz A
PARASITE IMMUNOLOGY 2003;25(4):189-97

Adjuvant modulation of the immune responses and the outcome of infection with Chlamydia pneumoniae
Bandholtz L, Kreuger Mr, Svanholm C, Wigzell H, Rottenberg Me
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2002;130(3):393-403

Chlamydia pneumoniae infection and atherosclerosis: Methodological considerations - Response
Caligiuri G, Rottenberg M, Wigzell T, Hansson Gk, Nicoletti A
CIRCULATION 2002;105(4):E34-E34

Colony-stimulating factor 1-dependent cells protect against systemic infection with Listeria monocytogenes but facilitate neuroinvasion
Jin Yx, Dons L, Kristensson K, Rottenberg Me
INFECTION AND IMMUNITY 2002;70(8):4682-6

Effects of interferon-gamma on neuronal infections
Rottenberg M, Kristensson K
VIRAL IMMUNOLOGY 2002;15(2):247-60

The role of IFN-gamma in the outcome of chlamydial infection
Rottenberg Me, Gigliotti-rothfuchs A, Wigzell H
CURRENT OPINION IN IMMUNOLOGY 2002;14(4):444-51

Chlamydia pneumoniae infection does not induce or modify atherosclerosis in mice
Caligiuri G, Rottenberg M, Nicoletti A, Wigzell H, Hansson Gk
CIRCULATION 2001;103(23):2834-8

IFN-alpha beta-dependent, IFN-gamma secretion by bone-marrow-derived macrophages controls an intracellular bacterial infection
Rothfuchs Ag, Gigliotti D, Palmblad K, Andersson U, Wigzell H, Rottenberg Me
JOURNAL OF IMMUNOLOGY 2001;167(11):6453-61

Neural route of cerebral Listeria monocytogenes murine infection: Role of immune response mechanisms in controling bacterial neuroinvasion
Jin Yx, Dons L, Kristensson K, Rottenberg Me
INFECTION AND IMMUNITY 2001;69(2):1093-100

Comparison of anesthetics for inoculation of mice with Chlamydia pneumoniae
Erkkila L, Rottenberg Me, Laitinen K
COMPARATIVE MEDICINE 2000;50(1):46-8

Protective DNA immunization against Chlamydia pneumoniae
Svanholm C, Bandholtz L, Castanos-velez E, Wigzell H, Rottenberg Me
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2000;51(4):345-53

Regulation and role of IFN-gamma in the innate resistance to infection with Chlamydia pneumoniae
Rottenberg Me, Rothfuchs Ag, Gigliotti D, Ceausu M, Une C, Levitsky V, et al
JOURNAL OF IMMUNOLOGY 2000;164(9):4812-8

Antibody and Th1/Th2-type responses in BALB/c mice inoculated with live or dead Echinococcus granulosus protoscoleces
Dematteis S, Baz A, Rottenberg M, Fernandez C, Orn A, Nieto A
PARASITE IMMUNOLOGY 1999;21(1):19-26

Light-dependent regulation and postnatal development of the interferon-gamma receptor in the rat suprachiasmatic nuclei
Lundkvist Gb, Andersson A, Robertson B, Rottenberg Me, Kristensson K
BRAIN RESEARCH 1999;849(1-2):231-4

Role of innate and adaptive immunity in the outcome of primary infection with Chlamydia pneumoniae, as analyzed in genetically modified mice
Rottenberg Me, Rothfuchs Acg, Gigliotti D, Svanholm C, Bandholtz L, Wigzell H
JOURNAL OF IMMUNOLOGY 1999;162(5):2829-36

Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37
Johansson J, Gudmundsson Gh, Rottenberg Me, Berndt Kd, Agerberth B
JOURNAL OF BIOLOGICAL CHEMISTRY 1998;273(6):3718-24

Expression of an oscillating interferon-gamma receptor in the suprachiasmatic nuclei
Lundkvist Gb, Robertson B, Mhlanga Jdm, Rottenberg Me, Kristensson K
NEUROREPORT 1998;9(6):1059-63

Simultaneous cross-linking of CD6 and CD28 induces cell proliferation in resting T cells
Osorio Lm, Rottenberg M, Jondal M, Chow Sc
IMMUNOLOGY 1998;93(3):358-65

Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice
Castanos-velez E, Maerlan S, Osorio Lm, Aberg F, Biberfeld P, Orn A, et al
INFECTION AND IMMUNITY 1998;66(6):2960-8

Bcl-2, Bax and p53 expression in B-CLL in relation to in vitro survival and clinical progression
Aguilarsantelises M, Rottenberg Me, Lewin N, Mellstedt H, Jondal M
INTERNATIONAL JOURNAL OF CANCER 1996;69(2):114-9

Increased expression and secretion of ICAM-1 during experimental infection with Trypanosoma cruzi
Laucella S, Salcedo R, Castanosvelez E, Riarte A, Detitto Eh, Patarroyo M, et al
PARASITE IMMUNOLOGY 1996;18(5):227-39

Intracellular co-localization of Trypanosoma cruzi and inducible nitric oxide synthase (iNOS): Evidence for dual pathway of iNOS induction
Rottenberg Me, Castanovelez E, Demesquita R, Laguardia Og, Biberfeld P, Orn A
EUROPEAN JOURNAL OF IMMUNOLOGY 1996;26(12):3203-13

Soluble cell adhesion molecules in human Chagas' disease: Association with disease severity and stage of infection
Laucella S, Detitto Eh, Segura El, Orn A, Rottenberg Me
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 1996;55(6):629-34

CYTOKINE GENE-EXPRESSION DURING INFECTION OF MICE LACKING CD4 AND/OR CD8 WITH TRYPANOSOMA-CRUZI
Rottenberg Me, Sporrong L, Persson I, Wigzell H, Orn A
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 1995;41(2):164-70

OUTCOME OF INFECTION WITH DIFFERENT STRAINS OF TRYPANOSOMA-CRUZI IN MICE LACKING CD4 AND/OR CD8
Rottenberg Me, Riarte A, Sporrong L, Altcheh J, Petray P, Ruiz Am, et al
IMMUNOLOGY LETTERS 1995;45(1-2):53-60

ROLE OF NITRIC-OXIDE IN RESISTANCE AND HISTOPATHOLOGY DURING EXPERIMENTAL-INFECTION WITH TRYPANOSOMA-CRUZI
Petray P, Castanosvelez E, Grinstein S, Orn A, Rottenberg Me
IMMUNOLOGY LETTERS 1995;47(1-2):121-6

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