Marcos Miranda

About me
Publications
Public outreach and news

About me

Marcos received his Bachelor's of Science from the University of Washington
in 2019. He worked the next three years at the Institute for Protein Design
(IPD) in the Nanoparticle Production Core. At the IPD, his research focused
on production and characterization of novel protein nanoparticles for use as
nanomaterials and vaccines. Most of his worked focused on the development of
broadly protective sarbecovirus vaccines. He was awarded a Fulbright Grant in
2022 to research humoral responses to conserved epitopes on the human
metapneumovirus and respiratory syncytial virus fusion proteins.
Bachelor of Science in Microbiology and Public Health-Global Health,
University of Washington, Seattle, USA

Articles

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(11):e2214556120

Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains.

Wang JYJ; Khmelinskaia A; Sheffler W; Miranda MC; Antanasijevic A; Borst AJ; Torres SV; Shu C; Hsia Y; Nattermann U; Ellis D; Walkey C; Ahlrichs M; Chan S; Kang A; Nguyen H; Sydeman C; Sankaran B; Wu M; Bera AK; Carter L; Fiala B; Murphy M; Baker D; Ward AB; King NP
Article: BIOCHEMISTRY. 2023;62(2):358-368

Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins.

Gerben SR; Borst AJ; Hicks DR; Moczygemba I; Feldman D; Coventry B; Yang W; Bera AK; Miranda M; Kang A; Nguyen H; Baker D
Article: CELL REPORTS MEDICINE. 2022;3(10):100780

Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens.

Kraft JC; Pham MN; Shehata L; Brinkkemper M; Boyoglu-Barnum S; Sprouse KR; Walls AC; Cheng S; Murphy M; Pettie D; Ahlrichs M; Sydeman C; Johnson M; Blackstone A; Ellis D; Ravichandran R; Fiala B; Wrenn S; Miranda M; Sliepen K; Brouwer PJM; Antanasijevic A; Veesler D; Ward AB; Kanekiyo M; Pepper M; Sanders RW; King NP
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(9):e20220849

IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.

Hale M; Netland J; Chen Y; Thouvenel CD; Smith KN; Rich LM; Vanderwall ER; Miranda MC; Eggenberger J; Hao L; Watson MJ; Mundorff CC; Rodda LB; King NP; Guttman M; Gale M; Abraham J; Debley JS; Pepper M; Rawlings DJ
Article: CELL REPORTS. 2022;40(9):111299

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice.

Walls AC; VanBlargan LA; Wu K; Choi A; Navarro MJ; Lee D; Avena L; Berrueta DM; Pham MN; Elbashir S; Kraft JC; Miranda MC; Kepl E; Johnson M; Blackstone A; Sprouse K; Fiala B; O'Connor MA; Brunette N; Arunachalam PS; Shirreff L; Rogers K; Carter L; Fuller DH; Villinger F; Pulendran B; Diamond MS; Edwards DK; King NP; Veesler D
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(658):eabq4130

Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.

Arunachalam PS; Feng Y; Ashraf U; Hu M; Walls AC; Edara VV; Zarnitsyna VI; Aye PP; Golden N; Miranda MC; Green KWM; Threeton BM; Maness NJ; Beddingfield BJ; Bohm RP; Scheuermann SE; Goff K; Dufour J; Russell-Lodrigue K; Kepl E; Fiala B; Wrenn S; Ravichandran R; Ellis D; Carter L; Rogers K; Shirreff LM; Ferrell DE; Deb Adhikary NR; Fontenot J; Hammond HL; Frieman M; Grifoni A; Sette A; O'Hagan DT; Van Der Most R; Rappuoli R; Villinger F; Kleanthous H; Rappaport J; Suthar MS; Veesler D; Wang TT; King NP; Pulendran B
Article: CELL. 2022;185(13):2279-2291.e17

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein.

Tortorici MA; Walls AC; Joshi A; Park Y-J; Eguia RT; Miranda MC; Kepl E; Dosey A; Stevens-Ayers T; Boeckh MJ; Telenti A; Lanzavecchia A; King NP; Corti D; Bloom JD; Veesler D
Article: NPJ VACCINES. 2022;7(1):55

Adjuvanting a subunit SARS-CoV-2 vaccine with clinically relevant adjuvants induces durable protection in mice.

Grigoryan L; Lee A; Walls AC; Lai L; Franco B; Arunachalam PS; Feng Y; Luo W; Vanderheiden A; Floyd K; Wrenn S; Pettie D; Miranda MC; Kepl E; Ravichandran R; Sydeman C; Brunette N; Murphy M; Fiala B; Carter L; Coffman RL; Novack D; Kleanthous H; O'Hagan DT; van der Most R; McLellan JS; Suthar M; Veesler D; King NP; Pulendran B
Article: SCIENCE. 2021;374(6575):1621-1626

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.

McCallum M; Walls AC; Sprouse KR; Bowen JE; Rosen LE; Dang HV; De Marco A; Franko N; Tilles SW; Logue J; Miranda MC; Ahlrichs M; Carter L; Snell G; Pizzuto MS; Chu HY; Van Voorhis WC; Corti D; Veesler D
Article: CELL. 2021;184(21):5432-5447.e16

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.

Walls AC; Miranda MC; Schäfer A; Pham MN; Greaney A; Arunachalam PS; Navarro M-J; Tortorici MA; Rogers K; O'Connor MA; Shirreff L; Ferrell DE; Bowen J; Brunette N; Kepl E; Zepeda SK; Starr T; Hsieh C-L; Fiala B; Wrenn S; Pettie D; Sydeman C; Sprouse KR; Johnson M; Blackstone A; Ravichandran R; Ogohara C; Carter L; Tilles SW; Rappuoli R; Leist SR; Martinez DR; Clark M; Tisch R; O'Hagan DT; Van Der Most R; Van Voorhis WC; Corti D; McLellan JS; Kleanthous H; Sheahan TP; Smith KD; Fuller DH; Villinger F; Bloom J; Pulendran B; Baric RS; King NP; Veesler D
Article: NATURE. 2021;594(7862):253-258

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.

Arunachalam PS; Walls AC; Golden N; Atyeo C; Fischinger S; Li C; Aye P; Navarro MJ; Lai L; Edara VV; Röltgen K; Rogers K; Shirreff L; Ferrell DE; Wrenn S; Pettie D; Kraft JC; Miranda MC; Kepl E; Sydeman C; Brunette N; Murphy M; Fiala B; Carter L; White AG; Trisal M; Hsieh C-L; Russell-Lodrigue K; Monjure C; Dufour J; Spencer S; Doyle-Meyers L; Bohm RP; Maness NJ; Roy C; Plante JA; Plante KS; Zhu A; Gorman MJ; Shin S; Shen X; Fontenot J; Gupta S; O'Hagan DT; Van Der Most R; Rappuoli R; Coffman RL; Novack D; McLellan JS; Subramaniam S; Montefiori D; Boyd SD; Flynn JL; Alter G; Villinger F; Kleanthous H; Rappaport J; Suthar MS; King NP; Veesler D; Pulendran B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2021;218(4):e20200942

Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites.

Thouvenel CD; Fontana MF; Netland J; Krishnamurty AT; Takehara KK; Chen Y; Singh S; Miura K; Keitany GJ; Lynch EM; Portugal S; Miranda MC; King NP; Kollman JM; Crompton PD; Long CA; Pancera M; Rawlings DJ; Pepper M
Article: NATURE. 2021;591(7850):482-487

De novo design of modular and tunable protein biosensors.

Quijano-Rubio A; Yeh H-W; Park J; Lee H; Langan RA; Boyken SE; Lajoie MJ; Cao L; Chow CM; Miranda MC; Wi J; Hong HJ; Stewart L; Oh B-H; Baker D
Article: CELL. 2020;183(5):1367-1382.e17

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2.

Walls AC; Fiala B; Schäfer A; Wrenn S; Pham MN; Murphy M; Tse LV; Shehata L; O'Connor MA; Chen C; Navarro MJ; Miranda MC; Pettie D; Ravichandran R; Kraft JC; Ogohara C; Palser A; Chalk S; Lee E-C; Guerriero K; Kepl E; Chow CM; Sydeman C; Hodge EA; Brown B; Fuller JT; Dinnon KH; Gralinski LE; Leist SR; Gully KL; Lewis TB; Guttman M; Chu HY; Lee KK; Fuller DH; Baric RS; Kellam P; Carter L; Pepper M; Sheahan TP; Veesler D; King NP

All other publications

Preprint: BIORXIV. 2023;BIORXIV

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies.

Edman NI; Redler RL; Phal A; Schlichthaerle T; Srivatsan SR; Etemadi A; An SJ; Favor A; Ehnes D; Li Z; Praetorius F; Gordon M; Yang W; Coventry B; Hicks DR; Cao L; Bethel N; Heine P; Murray A; Gerben S; Carter L; Miranda M; Negahdari B; Lee S; Trapnell C; Stewart L; Ekiert DC; Schlessinger J; Shendure J; Bhabha G; Ruohola-Baker H; Baker D
Corrigendum: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(9):jem.2022084908172022c

Correction: IgM antibodies derived from memory B cells are potent cross-variant neutralizers of SARS-CoV-2.

Hale M; Netland J; Chen Y; Thouvenel CD; Smith KN; Rich LM; Vanderwall ER; Miranda MC; Eggenberger J; Hao L; Watson MJ; Mundorff CC; Rodda LB; King NP; Guttman M; Gale M; Abraham J; Debley JS; Pepper M; Rawlings DJ
Preprint: BIORXIV. 2021;BIORXIV

Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants.

McCallum M; Walls AC; Sprouse KR; Bowen JE; Rosen L; Dang HV; deMarco A; Franko N; Tilles SW; Logue J; Miranda MC; Ahlrichs M; Carter L; Snell G; Pizzuto MS; Chu HY; Van Voorhis WC; Corti D; Veesler D
Preprint: BIORXIV. 2021;BIORXIV

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines.

Walls AC; Miranda MC; Pham MN; Schäfer A; Greaney A; Arunachalam PS; Navarro M-J; Tortorici MA; Rogers K; O'Connor MA; Shireff L; Ferrell DE; Brunette N; Kepl E; Bowen J; Zepeda SK; Starr T; Hsieh C-L; Fiala B; Wrenn S; Pettie D; Sydeman C; Johnson M; Blackstone A; Ravichandran R; Ogohara C; Carter L; Tilles SW; Rappuoli R; O'Hagan DT; Van Der Most R; Van Voorhis WC; McLellan JS; Kleanthous H; Sheahan TP; Fuller DH; Villinger F; Bloom J; Pulendran B; Baric R; King N; Veesler D
Preprint: BIORXIV. 2020;BIORXIV

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2.

Walls AC; Fiala B; Schäfer A; Wrenn S; Pham MN; Murphy M; Tse LV; Shehata L; O'Connor MA; Chen C; Navarro MJ; Miranda MC; Pettie D; Ravichandran R; Kraft JC; Ogohara C; Palser A; Chalk S; Lee E-C; Kepl E; Chow CM; Sydeman C; Hodge EA; Brown B; Fuller JT; Dinnon KH; Gralinski LE; Leist SR; Gully KL; Lewis TB; Guttman M; Chu HY; Lee KK; Fuller DH; Baric RS; Kellam P; Carter L; Pepper M; Sheahan TP; Veesler D; King NP

About me

Articles

All other publications

News from KI

Events from KI