The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study.
Tissue Eng Part A 2008 Jul;14(7):1251-61
Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes.
Osteoarthr. Cartil. 2008 Aug;16(8):855-64
Increased oral fibroblast lifespan is telomerase-independent.
J. Dent. Res. 2009 Oct;88(10):916-21
A multipotent neural crest-derived progenitor cell population is resident within the oral mucosa lamina propria.
Stem Cells Dev. 2010 Jun;19(6):819-30
'Young' oral fibroblasts are geno/phenotypically distinct.
J. Dent. Res. 2010 Dec;89(12):1407-13
Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner.
Stem Cells Dev. 2012 Jun;21(9):1478-87
Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
Stem Cells 2014 Sep;32(9):2430-42
Identification of a transcriptional signature for the wound healing continuum.
Wound Repair Regen ;22(3):399-405
Mesenchymal stromal cells and the innate immune response.
Immunol. Lett. 2015 Dec;168(2):140-6
Oral Mucosal Lamina Propria-Progenitor Cells Exert Antibacterial Properties via the Secretion of Osteoprotegerin and Haptoglobin.
Stem Cells Transl Med 2015 Nov;4(11):1283-93
Enhanced oral healing following local mesenchymal stromal cell therapy.
Oral Oncol. 2015 Dec;51(12):e97-9
Oral mucosal progenitor cell clones resist in vitro myogenic differentiation.
Arch. Oral Biol. 2016 Oct;70():100-110
Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro.
Stem Cells Transl Med 2016 Nov;5(11):1485-1495
Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.
Stem Cells 2017 Mar;35(3):766-776
Oral Mucosal Progenitor Cells. P. Stephens and Davies LC Stem Cell Biology and Tissue Engineering in Dental Sciences. Elsevier Inc., 2015. Edited by:Ajay Vishwakarma, Paul Sharpe, Shi Songtao and Murugan Ramalingam
BSc (Hons) Applied and Human Biology, Aston University, Birmingham UK (1998-2001)
PhD Biochemistry, Cardiff University, Cardiff UK (2002-2006)
Fellowship of The Higher Education Academy, UK (2014)
My academic career has centred on the fields of stem cell biology and tissue engineering with respect to wound healing and the role of endogenous stem cells. My postdoctoral research focussed on stem cell immunology and the identification of a novel progenitor cell (PC) population within the oral mucosa lamina propria suitable for allogeneic tissue engineering. This work has stemmed from my interest in the preferential healing seen within the oral mucosa compared to the skin. Within the oral mucosa rapid healing is seen within no/minimal scar formation upon wounding. My recent work has focussed on characterising this newly discovered PC population, which may contribute to this preferential healing response. In particular this research has focussed on determining the neural-crest origin of this cell population, and successfully differentiating the cells down mesenchymal, neuronal and glial lineages with a view to future therapeutic applications (Davies et al., 2010). My continuing research focuses on the mechanisms by which oral mucosal PCs are able to both modulate the immune response (Davies et al., 2012) and regulate the oral microflora through the constitutive secretion of antibacterial factors.
Academic honors, awards and prizes
Senior Colgate Prize for research at the British Society of Dental Research/Nordisk Odontologisk Frening conference, 2007
International Association for Dental Research (IADR) Travel Award, 2008