Kenneth Chien

About me
Publications
Public outreach and news

About me

Professor of Cardiovascular Research.

Articles

Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2024;32(2):101225

Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart.

Al-Saadi J; Waldén M; Sandell M; Sohlmér J; Grankvist R; Friberger I; Andersson A; Carlsten M; Chien K; Lundberg J; Witman N; Holmin S
Article: NATURE COMMUNICATIONS. 2024;15(1):167

Derivation of human primordial germ cell-like cells in an embryonic-like culture.

Esfahani SN; Zheng Y; Arabpour A; Irizarry AMR; Kobayashi N; Xue X; Shao Y; Zhao C; Agranonik NL; Sparrow M; Hunt TJ; Faith J; Lara MJ; Wu QY; Silber S; Petropoulos S; Yang R; Chien KR; Clark AT; Fu J
Article: NATURE COMMUNICATIONS. 2023;14(1):5435

Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development.

Witman N; Zhou C; Häneke T; Xiao Y; Huang X; Rohner E; Sohlmér J; Grote Beverborg N; Lehtinen ML; Chien KR; Sahara M
Article: MOLECULAR THERAPY. 2023;31(3):866-874

Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting.

Anttila V; Saraste A; Knuuti J; Hedman M; Jaakkola P; Laugwitz K-L; Krane M; Jeppsson A; Sillanmäki S; Rosenmeier J; Zingmark P; Rudvik A; Garkaviy P; Watson C; Pangalos MN; Chien KR; Fritsche-Danielson R; Collén A; Gan L-M
Article: MOLECULAR THERAPY. 2023;31(1):211-229

Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI.

Ai X; Yan B; Witman N; Gong Y; Yang L; Tan Y; Chen Y; Liu M; Lu T; Luo R; Wang H; Chien KR; Wang W; Fu W
Article: CELL STEM CELL. 2022;29(9):1402-1419.e8

Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development.

Zheng Y; Yan RZ; Sun S; Kobayashi M; Xiang L; Yang R; Goedel A; Kang Y; Xue X; Esfahani SN; Liu Y; Resto Irizarry AM; Wu W; Li Y; Ji W; Niu Y; Chien KR; Li T; Shioda T; Fu J
Article: NATURE COMMUNICATIONS. 2022;13(1):3018

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.

De Genst E; Foo KS; Xiao Y; Rohner E; de Vries E; Sohlmér J; Witman N; Hidalgo A; Kolstad TRS; Louch WE; Pehrsson S; Park A; Ikeda Y; Li X; Mayr LM; Wickson K; Jennbacken K; Hansson K; Fritsche-Danielson R; Hunt J; Chien KR
Article: NATURE CELL BIOLOGY. 2022;24(5):659-671

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.

Poch CM; Foo KS; De Angelis MT; Jennbacken K; Santamaria G; Bähr A; Wang Q-D; Reiter F; Hornaschewitz N; Zawada D; Bozoglu T; My I; Meier A; Dorn T; Hege S; Lehtinen ML; Tsoi YL; Hovdal D; Hyllner J; Schwarz S; Sudhop S; Jurisch V; Sini M; Fellows MD; Cummings M; Clarke J; Baptista R; Eroglu E; Wolf E; Klymiuk N; Lu K; Tomasi R; Dendorfer A; Gaspari M; Parrotta E; Cuda G; Krane M; Sinnecker D; Hoppmann P; Kupatt C; Fritsche-Danielson R; Moretti A; Chien KR; Laugwitz K-L
Article: NATURE CELL BIOLOGY. 2022;24(5):645-658

Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders.

Eroglu E; Yen CYT; Tsoi Y-L; Witman N; Elewa A; Joven Araus A; Wang H; Szattler T; Umeano CH; Sohlmér J; Goedel A; Simon A; Chien KR
Article: JCI INSIGHT. 2022;7(2):e152198

Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors.

Tang CSM; Mononen M; Lam W-Y; Jin SC; Zhuang X; Garcia-Barcelo M-M; Lin Q; Yang Y; Sahara M; Eroglu E; Chien KR; Hong H; Tam PKH; Gruber PJ
Article: MOLECULAR MEDICINE. 2021;27(1):102

An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation.

Rohner E; Witman N; Sohlmer J; De Genst E; Louch WE; Sahara M; Chien KR
Article: NATURE COMMUNICATIONS. 2021;12(1):5180

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.

Grote Beverborg N; Später D; Knöll R; Hidalgo A; Yeh ST; Elbeck Z; Silljé HHW; Eijgenraam TR; Siga H; Zurek M; Palmér M; Pehrsson S; Albery T; Bomer N; Hoes MF; Boogerd CJ; Frisk M; van Rooij E; Damle S; Louch WE; Wang Q-D; Fritsche-Danielson R; Chien KR; Hansson KM; Mullick AE; de Boer RA; van der Meer P
Article: NATURE COMMUNICATIONS. 2021;12(1):5126

Amnion signals are essential for mesoderm formation in primates.

Yang R; Goedel A; Kang Y; Si C; Chu C; Zheng Y; Chen Z; Gruber PJ; Xiao Y; Zhou C; Witman N; Eroglu E; Leung C-Y; Chen Y; Fu J; Ji W; Lanner F; Niu Y; Chien KR
Article: STAR PROTOCOLS. 2021;2(1):100339

Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis.

Santoro F; Chien KR; Sahara M
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):82

BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways.

Geng Y; Duan H; Xu L; Witman N; Yan B; Yu Z; Wang H; Tan Y; Lin L; Li D; Bai S; Fritsche-Danielson R; Yuan J; Chien K; Wei M; Fu W
Article: STEM CELLS. 2020;38(10):1267-1278

Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage.

Mononen MM; Leung CY; Xu J; Chien KR
Article: CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY. 2020;9(7):384-394

Model-Based Analysis Reveals a Sustained and Dose-Dependent Acceleration of Wound Healing by VEGF-A mRNA (AZD8601).

Almquist J; Rikard SM; Wågberg M; Bruce AC; Gennemark P; Fritsche-Danielson R; Chien KR; Peirce SM; Hansson K; Lundahl A
Article: STEM CELLS. 2020;38(6):741-755

Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors.

Xu J; Zhou C; Foo KS; Yang R; Xiao Y; Bylund K; Sahara M; Chien KR
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(4):398-406

Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine.

Grankvist R; Jensen-Urstad M; Clarke J; Lehtinen M; Little P; Lundberg J; Arnberg F; Jonsson S; Chien KR; Holmin S
Article: NATURE BIOTECHNOLOGY. 2019;37(3):232-237

Regenerating the field of cardiovascular cell therapy.

Chien KR; Frisén J; Fritsche-Danielson R; Melton DA; Murry CE; Weissman IL
Article: DEVELOPMENTAL CELL. 2019;48(4):475-490.e7

Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract.

Sahara M; Santoro F; Sohlmér J; Zhou C; Witman N; Leung CY; Mononen M; Bylund K; Gruber P; Chien KR
Article: NATURE COMMUNICATIONS. 2019;10(1):871

Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes.

Gan L-M; Lagerström-Fermér M; Carlsson LG; Arfvidsson C; Egnell A-C; Rudvik A; Kjaer M; Collén A; Thompson JD; Joyal J; Chialda L; Koernicke T; Fuhr R; Chien KR; Fritsche-Danielson R
Article: STEM CELLS. 2019;37(2):216-225

SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation.

Xu J; Gruber PJ; Chien KR
Article: SCIENTIFIC REPORTS. 2018;8(1):17509

Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing.

Sun N; Ning B; Hansson KM; Bruce AC; Seaman SA; Zhang C; Rikard M; DeRosa CA; Fraser CL; Wågberg M; Fritsche-Danielson R; Wikström J; Chien KR; Lundahl A; Hölttä M; Carlsson LG; Peirce SM; Hu S
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659

Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2018;9:330-346

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine.

Carlsson L; Clarke JC; Yen C; Gregoire F; Albery T; Billger M; Egnell A-C; Gan L-M; Jennbacken K; Johansson E; Linhardt G; Martinsson S; Sadiq MW; Witman N; Wang Q-D; Chen C-H; Wang Y-P; Lin S; Ticho B; Hsieh PCH; Chien KR; Fritsche-Danielson R
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.

Andersson ER; Chivukula IV; Hankeova S; Sjöqvist M; Tsoi YL; Ramsköld D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netušilová J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: CIRCULATION. 2017;135(1):59-72

Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.

Zangi L; Oliveira MS; Ye LY; Ma Q; Sultana N; Hadas Y; Chepurko E; Später D; Zhou B; Chew WL; Ebina W; Abrial M; Wang Q-D; Pu WT; Chien KR
Article: NATURE COMMUNICATIONS. 2016;7:10774

Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh B-S; Ng S-Y; Wu H; Buac K; Park J-HC; Lian X; Xu J; Foo KS; Felldin U; He X; Nichane M; Yang H; Bu L; Li RA; Lim B; Chien KR
Article: NATURE COMMUNICATIONS. 2014;5:5629

Tolerance induction to human stem cell transplants with extension to their differentiated progeny.

Lui KO; Howie D; Ng S-W; Liu S; Chien KR; Waldmann H
Article: DEVELOPMENT. 2014;141(23):4418-4431

How to make a cardiomyocyte.

Später D; Hansson EM; Zangi L; Chien KR
Article: CELL RESEARCH. 2014;24(12):1420-1432

N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment.

Soh B-S; Buac K; Xu H; Li E; Ng S-Y; Wu H; Chmielowiec J; Jiang X; Bu L; Li RA; Cowan C; Chien KR
Article: CELL REPORTS. 2014;9(3):810-821

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

Drawnel FM; Boccardo S; Prummer M; Delobel F; Graff A; Weber M; Gérard R; Badi L; Kam-Thong T; Bu L; Jiang X; Hoflack J-C; Kiialainen A; Jeworutzki E; Aoyama N; Carlson C; Burcin M; Gromo G; Boehringer M; Stahlberg H; Hall BJ; Magnone MC; Kolaja K; Chien KR; Bailly J; Iacone R
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2014;5(1):a014035

Synthetic chemically modified mRNA (modRNA): toward a new technology platform for cardiovascular biology and medicine.

Chien KR; Zangi L; Lui KO
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2014;4(12):a013920

Next-generation models of human cardiogenesis via genome editing.

Lian X; Xu J; Li J; Chien KR
Article: CELL RESEARCH. 2014;24(7):820-841

Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.

Sahara M; Hansson EM; Wernet O; Lui KO; Später D; Chien KR
Article: NATURE MEDICINE. 2014;20(6):616-623

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Wang G; McCain ML; Yang L; He A; Pasqualini FS; Agarwal A; Yuan H; Jiang D; Zhang D; Zangi L; Geva J; Roberts AE; Ma Q; Ding J; Chen J; Wang D-Z; Li K; Wang J; Wanders RJA; Kulik W; Vaz FM; Laflamme MA; Murry CE; Chien KR; Kelley RI; Church GM; Parker KK; Pu WT
Article: PLOS ONE. 2014;9(4):e93638

The muscle ankyrin repeat proteins CARP, Ankrd2, and DARP are not essential for normal cardiac development and function at basal conditions and in response to pressure overload.

Bang M-L; Gu Y; Dalton ND; Peterson KL; Chien KR; Chen J
Article: CELL RESEARCH. 2013;23(10):1172-1186

Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA.

Lui KO; Zangi L; Silva EA; Bu L; Sahara M; Li RA; Mooney DJ; Chien KR
Article: NATURE BIOTECHNOLOGY. 2013;31(10):898-907

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.

Zangi L; Lui KO; von Gise A; Ma Q; Ebina W; Ptaszek LM; Später D; Xu H; Tabebordbar M; Gorbatov R; Sena B; Nahrendorf M; Briscoe DM; Li RA; Wagers AJ; Rossi DJ; Pu WT; Chien KR
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2013;3(10):a013847

Embryonic heart progenitors and cardiogenesis.

Brade T; Pane LS; Moretti A; Chien KR; Laugwitz K-L
Article: NATURE CELL BIOLOGY. 2013;15(9):1098-1106

A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells.

Später D; Abramczuk MK; Buac K; Zangi L; Stachel MW; Clarke J; Sahara M; Ludwig A; Chien KR
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2013;3(9):a014050

Direct cardiomyocyte reprogramming: a new direction for cardiovascular regenerative medicine.

Yi BA; Mummery CL; Chien KR
Article: LANCET. 2012;379(9819):933-942

Towards regenerative therapy for cardiac disease.

Ptaszek LM; Mansour M; Ruskin JN; Chien KR
Article: CELL RESEARCH. 2012;22(1):142-154

Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature.

Xu H; Yi BA; Wu H; Bock C; Gu H; Lui KO; Park J-HC; Shao Y; Riley AK; Domian IJ; Hu E; Willette R; Lepore J; Meissner A; Wang Z; Chien KR
Article: CIRCULATION RESEARCH. 2011;109(7):758-769

Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart.

Knöll R; Linke WA; Zou P; Miocic S; Kostin S; Buyandelger B; Ku C-H; Neef S; Bug M; Schäfer K; Knöll G; Felkin LE; Wessels J; Toischer K; Hagn F; Kessler H; Didié M; Quentin T; Maier LS; Teucher N; Unsöld B; Schmidt A; Birks EJ; Gunkel S; Lang P; Granzier H; Zimmermann W-H; Field LJ; Faulkner G; Dobbelstein M; Barton PJR; Sattler M; Wilmanns M; Chien KR
Article: CARDIOVASCULAR RESEARCH. 2011;91(2):289-299

Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.

Terada R; Warren S; Lu JT; Chien KR; Wessels A; Kasahara H
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2011;50(2):337-345

Cardiac origin of smooth muscle cells in the inflow tract.

Nakano H; Williams E; Hoshijima M; Sasaki M; Minamisawa S; Chien KR; Nakano A
Article: NATURE BIOTECHNOLOGY. 2010;28(6):611-615

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.

Rodin S; Domogatskaya A; Ström S; Hansson EM; Chien KR; Inzunza J; Hovatta O; Tryggvason K
Article: CIRCULATION RESEARCH. 2010;106(4):695-704

A common MLP (muscle LIM protein) variant is associated with cardiomyopathy.

Knöll R; Kostin S; Klede S; Savvatis K; Klinge L; Stehle I; Gunkel S; Kötter S; Babicz K; Sohns M; Miocic S; Didié M; Knöll G; Zimmermann WH; Thelen P; Bickeböller H; Maier LS; Schaper W; Schaper J; Kraft T; Tschöpe C; Linke WA; Chien KR
Article: SCIENCE. 2009;326(5951):426-429

Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.

Domian IJ; Chiravuri M; van der Meer P; Feinberg AW; Shi X; Shao Y; Wu SM; Parker KK; Chien KR
Article: LABORATORY INVESTIGATION. 2009;89(9):983-993

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.

Takeda M; Briggs LE; Wakimoto H; Marks MH; Warren SA; Lu JT; Weinberg EO; Robertson KD; Chien KR; Kasahara H
Article: CELL CALCIUM. 2009;46(3):219-225

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.

Andersson KB; Finsen AV; Sjåland C; Winer LH; Sjaastad I; Odegaard A; Louch WE; Wang Y; Chen J; Chien KR; Sejersted OM; Christensen G
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2009;47(2):180-187

Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.

Andersson KB; Birkeland JAK; Finsen AV; Louch WE; Sjaastad I; Wang Y; Chen J; Molkentin JD; Chien KR; Sejersted OM; Christensen G
Article: NATURE. 2009;460(7251):113-117

Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages.

Bu L; Jiang X; Martin-Puig S; Caron L; Zhu S; Shao Y; Roberts DJ; Huang PL; Domian IJ; Chien KR
Article: DEVELOPMENT. 2009;136(3):495-505

Prox1 maintains muscle structure and growth in the developing heart.

Risebro CA; Searles RG; Melville AAD; Ehler E; Jina N; Shah S; Pallas J; Hubank M; Dillard M; Harvey NL; Schwartz RJ; Chien KR; Oliver G; Riley PR
Article: HUMAN MOLECULAR GENETICS. 2008;17(18):2753-2765

Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy.

Geier C; Gehmlich K; Ehler E; Hassfeld S; Perrot A; Hayess K; Cardim N; Wenzel K; Erdmann B; Krackhardt F; Posch MG; Osterziel KJ; Bublak A; Nägele H; Scheffold T; Dietz R; Chien KR; Spuler S; Fürst DO; Nürnberg P; Ozcelik C
Article: CIRCULATION RESEARCH. 2008;103(6):580-590

Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects.

Briggs LE; Takeda M; Cuadra AE; Wakimoto H; Marks MH; Walker AJ; Seki T; Oh SP; Lu JT; Sumners C; Raizada MK; Horikoshi N; Weinberg EO; Yasui K; Ikeda Y; Chien KR; Kasahara H
Article: NATURE. 2008;454(7200):109-113

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.

Zhou B; Ma Q; Rajagopal S; Wu SM; Domian I; Rivera-Feliciano J; Jiang D; von Gise A; Ikeda S; Chien KR; Pu WT
Article: CIRCULATION RESEARCH. 2008;102(5):571-580

Identification of cardiac-specific myosin light chain kinase.

Chan JY; Takeda M; Briggs LE; Graham ML; Lu JT; Horikoshi N; Weinberg EO; Aoki H; Sato N; Chien KR; Kasahara H
Article: NATURE BIOTECHNOLOGY. 2008;26(3):313-315

Marked differences in differentiation propensity among human embryonic stem cell lines.

Osafune K; Caron L; Borowiak M; Martinez RJ; Fitz-Gerald CS; Sato Y; Cowan CA; Chien KR; Melton DA
Article: CELL. 2008;132(4):537-543

Origins and fates of cardiovascular progenitor cells.

Wu SM; Chien KR; Mummery C
Article: CIRCULATION JOURNAL. 2007;71(12):1958-1964

Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice.

Yamamoto R; Akazawa H; Ito K; Toko H; Sano M; Yasuda N; Qin Y; Kudo Y; Sugaya T; Chien KR; Komuro I
Article: CELL STEM CELL. 2007;1(2):165-179

The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.

Qyang Y; Martin-Puig S; Chiravuri M; Chen S; Xu H; Bu L; Jiang X; Lin L; Granger A; Moretti A; Caron L; Wu X; Clarke J; Taketo MM; Laugwitz K-L; Moon RT; Gruber P; Evans SM; Ding S; Chien KR
Article: CIRCULATION. 2007;116(5):515-525

Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.

Knöll R; Postel R; Wang J; Krätzner R; Hennecke G; Vacaru AM; Vakeel P; Schubert C; Murthy K; Rana BK; Kube D; Knöll G; Schäfer K; Hayashi T; Holm T; Kimura A; Schork N; Toliat MR; Nürnberg P; Schultheiss H-P; Schaper W; Schaper J; Bos E; Den Hertog J; van Eeden FJM; Peters PJ; Hasenfuss G; Chien KR; Bakkers J
Article: EMBO JOURNAL. 2007;26(14):3283-3295

Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly.

Hirai M; Horiguchi M; Ohbayashi T; Kita T; Chien KR; Nakamura T
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2007;50(3):253-260

Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals.

Kaye DM; Preovolos A; Marshall T; Byrne M; Hoshijima M; Hajjar R; Mariani JA; Pepe S; Chien KR; Power JM
Article: MOLECULAR BIOLOGY OF THE CELL. 2007;18(5):1723-1733

The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation.

Pomiès P; Pashmforoush M; Vegezzi C; Chien KR; Auffray C; Beckerle MC
Article: JOURNAL OF CELL BIOLOGY. 2007;176(7):1061-1071

Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo.

Hirai M; Ohbayashi T; Horiguchi M; Okawa K; Hagiwara A; Chien KR; Kita T; Nakamura T
Article: CELL. 2007;128(5):947-959

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.

Prall OWJ; Menon MK; Solloway MJ; Watanabe Y; Zaffran S; Bajolle F; Biben C; McBride JJ; Robertson BR; Chaulet H; Stennard FA; Wise N; Schaft D; Wolstein O; Furtado MB; Shiratori H; Chien KR; Hamada H; Black BL; Saga Y; Robertson EJ; Buckingham ME; Harvey RP
Article: CARDIOVASCULAR RESEARCH. 2007;73(4):739-749

Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection.

Teutsch C; Kondo RP; Dederko DA; Chrast J; Chien KR; Giles WR
Article: NATURE. 2007;445(7124):177-182

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

Smart N; Risebro CA; Melville AAD; Moses K; Schwartz RJ; Chien KR; Riley PR
Article: CELL. 2006;127(6):1151-1165

Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.

Moretti A; Caron L; Nakano A; Lam JT; Bernshausen A; Chen Y; Qyang Y; Bu L; Sasaki M; Martin-Puig S; Sun Y; Evans SM; Laugwitz K-L; Chien KR
Article: CIRCULATION. 2006;114(22):2364-2373

Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.

Yajima T; Yasukawa H; Jeon E-S; Xiong D; Dorner A; Iwatate M; Nara M; Zhou H; Summers-Torres D; Hoshijima M; Chien KR; Yoshimura A; Knowlton KU
Article: CIRCULATION RESEARCH. 2006;99(7):749-757

Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation.

Weissgerber P; Held B; Bloch W; Kaestner L; Chien KR; Fleischmann BK; Lipp P; Flockerzi V; Freichel M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2006;80(4):850-861

Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.

Ricote M; Snyder CS; Leung H-Y; Chen J; Chien KR; Glass CK
Article: DEVELOPMENTAL BIOLOGY. 2006;291(2):208-217

Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development.

St Amand TR; Lu JT; Zamora M; Gu Y; Stricker J; Hoshijima M; Epstein JA; Ross JJ; Ruiz-Lozano P; Chien KR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2006;571(Pt 1):131-146

Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform.

Kondo RP; Dederko DA; Teutsch C; Chrast J; Catalucci D; Chien KR; Giles WR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(1):213-220

Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice.

Wang J; Hoshijima M; Lam J; Zhou Z; Jokiel A; Dalton ND; Hultenby K; Ruiz-Lozano P; Ross J; Tryggvason K; Chien KR
Article: SCIENTIST. 2006;20(8):34-39

Making a play at regrowing hearts

Chien K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(51):18455-18460

Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.

Merki E; Zamora M; Raya A; Kawakami Y; Wang J; Zhang X; Burch J; Kubalak SW; Kaliman P; Izpisua Belmonte JC; Chien KR; Ruiz-Lozano P
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2005;39(2):241-250

Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy.

Lorenzen-Schmidt I; Stuyvers BD; ter Keurs HEDJ; Date M-O; Hoshijima M; Chien KR; McCulloch AD; Omens JH
Article: MOLECULAR PSYCHIATRY. 2005;10(4):393-406

Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization.

Zhou X; Long JM; Geyer MA; Masliah E; Kelsoe JR; Wynshaw-Boris A; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(9):8016-8021

Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.

Kaliman P; Catalucci D; Lam JT; Kondo R; Gutiérrez JCP; Reddy S; Palacín M; Zorzano A; Chien KR; Ruiz-Lozano P
Article: NATURE. 2005;433(7026):647-653

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.

Laugwitz K-L; Moretti A; Lam J; Gruber P; Chen Y; Woodard S; Lin L-Z; Cai C-L; Lu MM; Reth M; Platoshyn O; Yuan JX-J; Evans S; Chien KR
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;325(3):852-856

Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.

Minamisawa S; Oshikawa J; Takeshima H; Hoshijima M; Wang Y; Chien KR; Ishikawa Y; Matsuoka R
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2004;44(11):2192-2201

Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy.

Hayashi T; Arimura T; Itoh-Satoh M; Ueda K; Hohda S; Inagaki N; Takahashi M; Hori H; Yasunami M; Nishi H; Koga Y; Nakamura H; Matsuzaki M; Choi BY; Bae SW; You CW; Han KH; Park JE; Knöll R; Hoshijima M; Chien KR; Kimura A
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(24):10611-10620

p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.

Nishida K; Yamaguchi O; Hirotani S; Hikoso S; Higuchi Y; Watanabe T; Takeda T; Osuka S; Morita T; Kondoh G; Uno Y; Kashiwase K; Taniike M; Nakai A; Matsumura Y; Miyazaki J-I; Sudo T; Hongo K; Kusakari Y; Kurihara S; Chien KR; Takeda J; Hori M; Otsu K
Article: EMBO JOURNAL. 2004;23(22):4517-4525

Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.

Pradervand S; Yasukawa H; Muller OG; Kjekshus H; Nakamura T; St Amand TR; Yajima T; Matsumura K; Duplain H; Iwatate M; Woodard S; Pedrazzini T; Ross J; Firsov D; Rossier BC; Hoshijima M; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(21):9414-9423

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.

Conrad M; Jakupoglu C; Moreno SG; Lippl S; Banjac A; Schneider M; Beck H; Hatzopoulos AK; Just U; Sinowatz F; Schmahl W; Chien KR; Wurst W; Bornkamm GW; Brielmeier M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(7):937-943

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.

Yamaguchi O; Watanabe T; Nishida K; Kashiwase K; Higuchi Y; Takeda T; Hikoso S; Hirotani S; Asahi M; Taniike M; Nakai A; Tsujimoto I; Matsumura Y; Miyazaki J-I; Chien KR; Matsuzawa A; Sadamitsu C; Ichijo H; Baccarini M; Hori M; Otsu K
Article: CARDIOVASCULAR RESEARCH. 2004;63(4):611-616

Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.

Smith RM; Suleman N; Lacerda L; Opie LH; Akira S; Chien KR; Sack MN
Article: CARDIOVASCULAR RESEARCH. 2004;63(2):293-304

Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice.

Carrier L; Knöll R; Vignier N; Keller DI; Bausero P; Prudhon B; Isnard R; Ambroisine M-L; Fiszman M; Ross J; Schwartz K; Chien KR
Article: NATURE MEDICINE. 2004;10(7):739-743

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

Mori H; Hanada R; Hanada T; Aki D; Mashima R; Nishinakamura H; Torisu T; Chien KR; Yasukawa H; Yoshimura A
Article: DEVELOPMENT. 2004;131(9):2219-2231

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.

Chen H; Shi S; Acosta L; Li W; Lu J; Bao S; Chen Z; Yang Z; Schneider MD; Chien KR; Conway SJ; Yoder MC; Haneline LS; Franco D; Shou W
Article: CELL. 2004;117(3):373-386

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

Pashmforoush M; Lu JT; Chen H; Amand TS; Kondo R; Pradervand S; Evans SM; Clark B; Feramisco JR; Giles W; Ho SY; Benson DW; Silberbach M; Shou W; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(10):3697-3702

The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure.

Bale TL; Hoshijima M; Gu Y; Dalton N; Anderson KR; Lee K-F; Rivier J; Chien KR; Vale WW; Peterson KL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(8):6905-6910

SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.

Kimura A; Kinjyo I; Matsumura Y; Mori H; Mashima R; Harada M; Chien KR; Yasukawa H; Yoshimura A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2004;286(1):H424-H433

Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.

Zheng M; Dilly K; Dos Santos Cruz J; Li M; Gu Y; Ursitti JA; Chen J; Ross J; Chien KR; Lederer JW; Wang Y
Article: GENE THERAPY. 2003;10(21):1814-1820

In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart.

Iwatate M; Gu Y; Dieterle T; Iwanaga Y; Peterson KL; Hoshijima M; Chien KR; Ross J
Article: NATURE IMMUNOLOGY. 2003;4(6):551-556

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

Yasukawa H; Ohishi M; Mori H; Murakami M; Chinen T; Aki D; Hanada T; Takeda K; Akira S; Hoshijima M; Hirano T; Chien KR; Yoshimura A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9570-9575

Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.

Minamisawa S; Wang Y; Chen J; Ishikawa Y; Chien KR; Matsuoka R
Article: BIOTECHNOLOGY AND BIOENGINEERING. 2003;81(5):578-587

Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers.

Gopalan SM; Flaim C; Bhatia SN; Hoshijima M; Knoell R; Chien KR; Omens JH; McCulloch AD
Article: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(4):469-478

The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.

Yasukawa H; Yajima T; Duplain H; Iwatate M; Kido M; Hoshijima M; Weitzman MD; Nakamura T; Woodard S; Xiong D; Yoshimura A; Chien KR; Knowlton KU
Article: EMBO JOURNAL. 2003;22(2):216-224

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.

Ludwig A; Budde T; Stieber J; Moosmang S; Wahl C; Holthoff K; Langebartels A; Wotjak C; Munsch T; Zong X; Feil S; Feil R; Lancel M; Chien KR; Konnerth A; Pape H-C; Biel M; Hofmann F
Article: METHODS IN MOLECULAR BIOLOGY. 2003;219:169-178

Embryonic and neonatal cardiac gene transfer in vivo.

Christensen G; Gruber PJ; Wang Y; Chien KR
Article: CELL. 2002;111(7):943-955

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy.

Knöll R; Hoshijima M; Hoffman HM; Person V; Lorenzen-Schmidt I; Bang M-L; Hayashi T; Shiga N; Yasukawa H; Schaper W; McKenna W; Yokoyama M; Schork NJ; Omens JH; McCulloch AD; Kimura A; Gregorio CC; Poller W; Schaper J; Schultheiss HP; Chien KR
Article: DEVELOPMENT. 2002;129(24):5827-5838

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

Hamblet NS; Lijam N; Ruiz-Lozano P; Wang J; Yang Y; Luo Z; Mei L; Chien KR; Sussman DJ; Wynshaw-Boris A
Article: MECHANISMS OF DEVELOPMENT. 2002;117(1-2):115-122

Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos.

Jiang X; Choudhary B; Merki E; Chien KR; Maxson RE; Sucov HM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(17):11375-11380

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice.

Zhao Y-Y; Liu Y; Stan R-V; Fan L; Gu Y; Dalton N; Chu P-H; Peterson K; Ross J; Chien KR
Article: NATURE MEDICINE. 2002;8(8):864-871

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.

Hoshijima M; Ikeda Y; Iwanaga Y; Minamisawa S; Date M-O; Gu Y; Iwatate M; Li M; Wang L; Wilson JM; Wang Y; Ross J; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8880-8885

Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.

Ozcelik C; Erdmann B; Pilz B; Wettschureck N; Britsch S; Hübner N; Chien KR; Birchmeier C; Garratt AN
Article: DEVELOPMENTAL DYNAMICS. 2002;224(2):154-167

Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development.

Ferrer-Martínez A; Ruiz-Lozano P; Chien KR
Article: NATURE MEDICINE. 2002;8(5):459-465

ErbB2 is essential in the prevention of dilated cardiomyopathy.

Crone SA; Zhao Y-Y; Fan L; Gu Y; Minamisawa S; Liu Y; Peterson KL; Chen J; Kahn R; Condorelli G; Ross J; Chien KR; Lee K-F
Article: CIRCULATION. 2002;105(4):502-508

Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer.

Ikeda Y; Gu Y; Iwanaga Y; Hoshijima M; Oh SS; Giordano FJ; Chen J; Nigro V; Peterson KL; Chien KR; Ross J
Article: NATURE. 2002;415(6868):171-175

Fibulin-5/DANCE is essential for elastogenesis in vivo.

Nakamura T; Lozano PR; Ikeda Y; Iwanaga Y; Hinek A; Minamisawa S; Cheng C-F; Kobuke K; Dalton N; Takada Y; Tashiro K; Ross J; Honjo T; Chien KR
Article: CELL. 2001;107(6):801-813

A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.

Kuo HC; Cheng CF; Clark RB; Lin JJ; Lin JL; Hoshijima M; Nguyêñ-Trân VT; Gu Y; Ikeda Y; Chu PH; Ross J; Giles WR; Chien KR
Article: REVISTA ESPANOLA DE CARDIOLOGIA. 2001;54(12):1439-1445

[Developmental genes and heart disease].

Ruiz-Lozano P; Nakamura T; Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;108(10):1459-1467

Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.

Yasukawa H; Hoshijima M; Gu Y; Nakamura T; Pradervand S; Hanada T; Hanakawa Y; Yoshimura A; Ross J; Chien KR
Article: NATURE MEDICINE. 2001;7(11):1236-1240

Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.

Wettschureck N; Rütten H; Zywietz A; Gehring D; Wilkie TM; Chen J; Chien KR; Offermanns S
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2001;280(6):H2665-H2673

Effects of deletion of muscle LIM protein on myocyte function.

Su Z; Yao A; Zubair I; Sugishita K; Ritter M; Li F; Hunter JJ; Chien KR; Barry WH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(10):5780-5785

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.

Giordano FJ; Gerber HP; Williams SP; VanBruggen N; Bunting S; Ruiz-Lozano P; Gu Y; Nath AK; Huang Y; Hickey R; Dalton N; Peterson KL; Ross J; Chien KR; Ferrara N
Article: NATURE MEDICINE. 2001;7(5):591-597

Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy.

Pashmforoush M; Pomiès P; Peterson KL; Kubalak S; Ross J; Hefti A; Aebi U; Beckerle MC; Chien KR
Article: CIRCULATION RESEARCH. 2001;88(3):333-339

Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.

Gutstein DE; Morley GE; Tamaddon H; Vaidya D; Schneider MD; Chen J; Chien KR; Stuhlmann H; Fishman GI
Article: NATURE. 2000;407(6801):227-232

Genomic circuits and the integrative biology of cardiac diseases.

Chien KR
Article: CELL. 2000;102(5):671-682

A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.

Nguyên-Trân VT; Kubalak SW; Minamisawa S; Fiset C; Wollert KC; Brown AB; Ruiz-Lozano P; Barrere-Lemaire S; Kondo R; Norman LW; Gourdie RG; Rahme MM; Feld GK; Clark RB; Giles WR; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 2000;20(12):4436-4444

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

Wan YJ; An D; Cai Y; Repa JJ; Hung-Po Chen T; Flores M; Postic C; Magnuson MA; Chen J; Chien KR; French S; Mangelsdorf DJ; Sucov HM
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2000;32(5):839-851

Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes.

Doevendans PA; Kubalak SW; An RH; Becker DK; Chien KR; Kass RS
Article: CIRCULATION. 2000;101(2):178-184

High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.

Christensen G; Minamisawa S; Gruber PJ; Wang Y; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(52):37362-37369

Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis.

Hertig CM; Kubalak SW; Wang Y; Chien KR
Article: HUMAN MOLECULAR GENETICS. 1999;8(12):2229-2237

Deletion of 150 kb in the minimal DiGeorge/velocardiofacial syndrome critical region in mouse.

Kimber WL; Hsieh P; Hirotsune S; Yuva-Paylor L; Sutherland HF; Chen A; Ruiz-Lozano P; Hoogstraten-Miller SL; Chien KR; Paylor R; Scambler PJ; Wynshaw-Boris A
Article: MOLECULAR PHARMACOLOGY. 1999;56(5):886-894

Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation.

Luo ZD; Wang Y; Werlen G; Camp S; Chien KR; Taylor P
Article: CELL. 1999;99(3):313-322

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.

Minamisawa S; Hoshijima M; Chu G; Ward CA; Frank K; Gu Y; Martone ME; Wang Y; Ross J; Kranias EG; Giles WR; Chien KR
Article: DEVELOPMENT. 1999;126(19):4223-4234

Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis.

Kuo H; Chen J; Ruiz-Lozano P; Zou Y; Nemer M; Chien KR
Article: MOLECULAR CELL. 1999;4(4):585-595

PPAR gamma is required for placental, cardiac, and adipose tissue development.

Barak Y; Nelson MC; Ong ES; Jones YZ; Ruiz-Lozano P; Chien KR; Koder A; Evans RM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(32):22476-22483

DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.

Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon NL; Schaub R; Matsumori A; Sasayama S; Chien KR; Honjo T
Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(12):1627-1634

Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.

Sah VP; Minamisawa S; Tam SP; Wu TH; Dorn GW; Ross J; Chien KR; Brown JH
Article: MOLECULAR CANCER RESEARCH. 1999;10(5):295-306

p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

Ruiz-Lozano P; Hixon ML; Wagner MW; Flores AI; Ikawa S; Baldwin AS; Chien KR; Gualberto A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(9):5043-5048

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.

Marszalek JR; Ruiz-Lozano P; Roberts E; Chien KR; Goldstein LS
Article: CELL. 1999;97(2):189-198

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.

Hirota H; Chen J; Betz UA; Rajewsky K; Gu Y; Ross J; Müller W; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(15):10066-10070

A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy.

Minamisawa S; Gu Y; Ross J; Chien KR; Chen J
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1998;30(11):2269-2280

Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy.

Schoenfeld JR; Vasser M; Jhurani P; Ng P; Hunter JJ; Ross J; Chien KR; Lowe DG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(22):13024-13029

Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail.

Liu X; Hwang H; Cao L; Buckland M; Cunningham A; Chen J; Chien KR; Graham RM; Zhou M
Article: JOURNAL OF CARDIAC FAILURE. 1998;4(3):213-224

Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.

Hongo M; Sentianin EM; Tanaka N; Mao L; McKirnan MD; Clark RG; Won W; Chien KR; Ross J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(17):10140-10145

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.

Adams JW; Sakata Y; Davis MG; Sah VP; Wang Y; Liggett SB; Chien KR; Brown JH; Dorn GW
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):21077-21083

A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation.

Cao L; Zhang L; Ruiz-Lozano P; Yang Q; Chien KR; Graham RM; Zhou M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(12):7000-7005

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.

Rockman HA; Chien KR; Choi DJ; Iaccarino G; Hunter JJ; Ross J; Lefkowitz RJ; Koch WJ
Article: DEVELOPMENT. 1998;125(10):1943-1949

Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.

Chen J; Kubalak SW; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(13):7725-7730

The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase.

Hoshijima M; Sah VP; Wang Y; Chien KR; Brown JH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(10):5423-5426

Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.

Wang Y; Su B; Sah VP; Brown JH; Han J; Chien KR
Article: DEVELOPMENT. 1998;125(3):533-544

Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos.

Ruiz-Lozano P; Smith SM; Perkins G; Kubalak SW; Boss GR; Sucov HM; Evans RM; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(4):2161-2168

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.

Wang Y; Huang S; Sah VP; Ross J; Brown JH; Han J; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(2):1252-1256

Selective requirement of myosin light chain 2v in embryonic heart function.

Chen J; Kubalak SW; Minamisawa S; Price RL; Becker KD; Hickey R; Ross J; Chien KR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(3 Pt 2):H1368-H1376

Left ventricular volumes and function in the embryonic mouse heart.

Tanaka N; Mao L; DeLano FA; Sentianin EM; Chien KR; Schmid-Schönbein GW; Ross J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(22):14057-14061

The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy.

Ramirez MT; Sah VP; Zhao XL; Hunter JJ; Chien KR; Brown JH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(9):4710-4715

Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice.

Gottshall KR; Hunter JJ; Tanaka N; Dalton N; Becker KD; Ross J; Chien KR
Article: JOURNAL OF CELL BIOLOGY. 1997;137(1):131-140

Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.

Becker KD; Gottshall KR; Hickey R; Perriard JC; Chien KR
Article: DEVELOPMENTAL DYNAMICS. 1997;208(4):482-490

Developmental expression of the murine spliceosome-associated protein mSAP49.

Ruiz-Lozano P; Doevendans P; Brown A; Gruber PJ; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(9):5783-5791

Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy.

Sheng Z; Knowlton K; Chen J; Hoshijima M; Brown JH; Chien KR
Article: DEVELOPMENT. 1997;124(4):793-804

CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.

Zou Y; Evans S; Chen J; Kuo HC; Harvey RP; Chien KR
Article: CELL. 1997;88(3):393-403

MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure.

Arber S; Hunter JJ; Ross J; Hongo M; Sansig G; Borg J; Perriard JC; Chien KR; Caroni P
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1997;29(2):515-525

A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy.

Harris AN; Ruiz-Lozano P; Chen YF; Sionit P; Yu YT; Lilly B; Olson EN; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(49):31185-31190

Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways.

Sah VP; Hoshijima M; Chien KR; Brown JH
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(11):2648-2655

Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.

Lembo G; Rockman HA; Hunter JJ; Steinmetz H; Koch WJ; Ma L; Prinz MP; Ross J; Chien KR; Powell-Braxton L
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(6):1332-1343

RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.

Gruber PJ; Kubalak SW; Pexieder T; Sucov HM; Evans RM; Chien KR
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1996;28(9):1833-1844

Neurofilament M mRNA is expressed in conduction system myocytes of the developing and adult rabbit heart.

Vitadello M; Vettore S; Lamar E; Chien KR; Gorza L
Article: CIRCULATION. 1996;94(5):1109-1117

Transthoracic echocardiography in models of cardiac disease in the mouse.

Tanaka N; Dalton N; Mao L; Rockman HA; Peterson KL; Gottshall KR; Hunter JJ; Chien KR; Ross J
Article: CIRCULATION. 1996;93(12):2188-2196

Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat.

Duerr RL; McKirnan MD; Gim RD; Clark RG; Chien KR; Ross J
Article: DEVELOPMENT. 1996;122(6):1799-1809

An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression.

Ross RS; Navankasattusas S; Harvey RP; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(16):9535-9545

Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.

Wollert KC; Taga T; Saito M; Narazaki M; Kishimoto T; Glembotski CC; Vernallis AB; Heath JK; Pennica D; Wood WI; Chien KR
Article: CIRCULATION RESEARCH. 1996;78(3):371-378

Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart.

An RH; Davies MP; Doevendans PA; Kubalak SW; Bangalore R; Chien KR; Kass RS
Article: DEVELOPMENT. 1996;122(2):419-428

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival.

Sheng Z; Pennica D; Wood WI; Chien KR
Article: CIRCULATION RESEARCH. 1996;78(1):15-25

Developmental changes in ionic channel activity in the embryonic murine heart.

Davies MP; An RH; Doevendans P; Kubalak S; Chien KR; Kass RS
Article: MOLECULAR BIOLOGY OF THE CELL. 1995;6(11):1479-1490

Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase.

Thorburn J; Carlson M; Mansour SJ; Chien KR; Ahn NG; Thorburn A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(39):23173-23178

Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.

Hunter JJ; Tanaka N; Rockman HA; Ross J; Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 1995;96(3):1311-1318

Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.

Knowlton KU; Rockman HA; Itani M; Vovan A; Seidman CE; Chien KR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;269(3 Pt 2):H755-H766

Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology.

Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(16):7391-7395

Retinoid-dependent pathways suppress myocardial cell hypertrophy.

Zhou MD; Sucov HM; Evans RM; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(16):7386-7390

Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.

Dyson E; Sucov HM; Kubalak SW; Schmid-Schönbein GW; DeLano FA; Evans RM; Ross J; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 1995;15(6):2972-2982

EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene.

Zou Y; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(4):1142-1146

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

Pennica D; King KL; Shaw KJ; Luis E; Rullamas J; Luoh SM; Darbonne WC; Knutzon DS; Yen R; Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 1995;95(2):619-627

Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure.

Duerr RL; Huang S; Miraliakbar HR; Clark R; Chien KR; Ross J
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Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):283

Author Correction: Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development.

Witman N; Zhou C; Häneke T; Xiao Y; Huang X; Rohner E; Sohlmér J; Grote Beverborg N; Lehtinen ML; Chien KR; Sahara M
Editorial comment: NATURE CELL BIOLOGY. 2023;25(2):203-206

Progress and challenges in stem cell biology.

Apostolou E; Blau H; Chien K; Lancaster MA; Tata PR; Trompouki E; Watt FM; Zeng YA; Zernicka-Goetz M
Review: NATURE BIOTECHNOLOGY. 2022;40(11):1586-1600

Unlocking the promise of mRNA therapeutics.

Rohner E; Yang R; Foo KS; Goedel A; Chien KR
Letter: NATURE REVIEWS DRUG DISCOVERY. 2022;21(1):79-80

VEGFA mRNA for regenerative treatment of heart failure.

Collén A; Bergenhem N; Carlsson L; Chien KR; Hoge S; Gan L-M; Fritsche-Danielson R
Editorial comment: NATURE CELL BIOLOGY. 2021;23(5):440-442

PHF7 directs cardiac reprogramming.

Eroglu E; Schell JP; Chien KR
Corrigendum: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2021;109:151

Corrigendum to "Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration" [Semin. Cell Dev. Biol. Vol.100 (2020) 29-51].

Witman N; Zhou C; Beverborg NG; Sahara M; Chien KR
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2020;100:29-51

Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration.

Witman N; Zhou C; Grote Beverborg N; Sahara M; Chien KR
Editorial comment: EMBO MOLECULAR MEDICINE. 2019;11(12):e11502

In search of the next super models.

Goedel A; Grote Beverborg N; Sahara M; Chien KR
Published conference paper: JOURNAL OF CONTROLLED RELEASE. 2019;310:103-114

Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia.

Yu Z; Witman N; Wang W; Li D; Yan B; Deng M; Wang X; Wang H; Zhou G; Liu W; Sahara M; Cao Y; Fritsche-Danielson R; Zhang W; Fu W; Chien KR
Editorial comment: CELL STEM CELL. 2018;22(6):787-789

Lnc'ed in to Cardiogenesis.

Sahara M; Eroglu E; Chien KR
Editorial comment: DEVELOPMENTAL CELL. 2017;42(1):7-8

Heart Regeneration 4.0: Matrix Medicine.

Eroglu E; Chien KR
Corrigendum: NATURE COMMUNICATIONS. 2016;7:12118

Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh B-S; Ng S-Y; Wu H; Buac K; Park J-HC; Lian X; Xu J; Foo KS; Felldin U; He X; Nichane M; Yang H; Bu L; Li RA; Lim B; Chien KR
Editorial comment: EMBO REPORTS. 2015;16(10):1246-1249

Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances.

Ljunggren H-G; Chien KR
Review: EMBO JOURNAL. 2015;34(6):710-738

Programming and reprogramming a human heart cell.

Sahara M; Santoro F; Chien KR
Corrigendum: CELL RESEARCH. 2015;25(1):148

Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells.

Sahara M; Hansson EM; Wernet O; Lui KO; Später D; Chien KR
Review: STEM CELL RESEARCH. 2014;13(3 Pt B):693-704

Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA.

Lui KO; Zangi L; Chien KR
Editorial comment: CELL RESEARCH. 2013;23(10):1161-1162

The years of the monkey.

Lian X; Chien KR
Editorial comment: EMBO REPORTS. 2013;14(9):755-758

Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt.

Chien K
Editorial comment: NATURE. 2013;498(7455):439-440

Regenerative biology: heartbroken embryos heal.

Chien KR
Editorial comment: NATURE BIOTECHNOLOGY. 2013;31(3):209-211

Cardiac regenerative medicine 2.0.

Soh B-S; Wu H; Chien KR
Editorial comment: CELL RESEARCH. 2012;22(11):1521-1523

In vivo reprogramming for heart disease.

Xu H; Yi BA; Chien KR
Editorial comment: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2012;53(3):311-313

Cardiomyocyte reprogramming and the new age of cellular alchemy.

Chien KR; Yi BA; Xu H; Mummery CL
Editorial comment: CELL STEM CELL. 2012;11(1):3-4

Reprogramming a broken heart.

Hansson EM; Chien KR
Editorial comment: MOLECULAR THERAPY. 2011;19(9):1576-1578

A GPS for heart progenitor cell lineages.

Chmielowiec J; Chang Y-S; Chien KR
Review: ANNUAL REVIEW OF BIOMEDICAL ENGINEERING. 2011;13:245-267

Bioengineering heart muscle: a paradigm for regenerative medicine.

Vunjak-Novakovic G; Lui KO; Tandon N; Chien KR
Editorial comment: NATURE CELL BIOLOGY. 2011;13(3):191-193

Shortcuts to making cardiomyocytes.

Xu H; Yi BA; Chien KR
Review: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 2010;26:667-687

Stem cell models of cardiac development and disease.

Musunuru K; Domian IJ; Chien KR
Letter: CELL RESEARCH. 2010;20(3):379-382

Targeted conditional gene knockout in human embryonic stem cells.

Bu L; Gao X; Jiang X; Chien KR; Wang Z
Review: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(1):20-28

Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.

Yi BA; Wernet O; Chien KR
Review: CELL STEM CELL. 2009;5(4):364-377

Regeneration next: toward heart stem cell therapeutics.

Hansson EM; Lindsay ME; Chien KR
Review: SCIENCE. 2008;322(5907):1494-1497

Cardiogenesis and the complex biology of regenerative cardiovascular medicine.

Chien KR; Domian IJ; Parker KK
Editorial comment: NATURE. 2008;453(7193):302-305

Regenerative medicine and human models of human disease.

Chien KR
Review: CELL STEM CELL. 2008;2(4):320-331

Lives of a heart cell: tracing the origins of cardiac progenitors.

Martin-Puig S; Wang Z; Chien KR
Review: PHYSIOLOGY. 2008;23:6-16

Toward biologically targeted therapy of calcium cycling defects in heart failure.

Ikeda Y; Hoshijima M; Chien KR
Review: ANNUAL REVIEW OF MEDICINE. 2008;59:13-28

Reversing advanced heart failure by targeting Ca2+ cycling.

Kaye DM; Hoshijima M; Chien KR
Review: DEVELOPMENT. 2008;135(2):193-205

Islet1 cardiovascular progenitors: a single source for heart lineages?

Laugwitz K-L; Moretti A; Caron L; Nakano A; Chien KR
Review: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2008;73:297-306

Multipotent islet-1 cardiovascular progenitors in development and disease.

Nakano A; Nakano H; Chien KR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1112:171-188

Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium.

Smart N; Risebro CA; Melville AAD; Moses K; Schwartz RJ; Chien KR; Riley PR
Editorial comment: NATURE. 2007;447(7143):389-390

Molecular medicine: microRNAs and the tell-tale heart.

Chien KR
Published conference paper: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2006;48(9 Suppl 1):A15-A23

Reversal of calcium cycling defects in advanced heart failure toward molecular therapy.

Hoshijima M; Knöll R; Pashmforoush M; Chien KR
Review: NOVARTIS FOUNDATION SYMPOSIUM. 2006;274:244-276

Beyond small molecule drugs for heart failure: prospects for gene therapy.

Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1838-1840

Lost and found: cardiac stem cell therapy revisited.

Chien KR
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(8):789-790

Herceptin and the heart--a molecular modifier of cardiac failure.

Chien KR
Editorial comment: PLOS BIOLOGY. 2005;3(4):e131

Alchemy and the new age of cardiac muscle cell biology.

Chien KR
Review: CELL. 2005;120(4):533-544

Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.

Chien KR; Karsenty G
Editorial comment: SCIENCE. 2004;306(5694):239-240

Development. ES cells to the rescue.

Chien KR; Moretti A; Laugwitz K-L
Editorial comment: NATURE CELL BIOLOGY. 2004;6(9):807-808

Unravelling Ras signals in cardiovascular disease.

Chien KR; Hoshijima M
Editorial comment: NATURE. 2004;428(6983):607-608

Stem cells: lost in translation.

Chien KR
Review: NOVARTIS FOUNDATION SYMPOSIUM. 2003;250:260-279

Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease.

St Amand TR; Lu JT; Chien KR
Editorial comment: NATURE MEDICINE. 2003;9(5):508-509

Calcium and heart failure: the cycle game.

Chien KR; Ross J; Hoshijima M
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(9):1433

Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies (vol 111, pg 175, 2003)

Chien KR
Review: TRENDS IN MOLECULAR MEDICINE. 2003;9(2):59-66

Genetic modifiers of cardiac arrhythmias.

Cheng C-F; Kuo H-C; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(2):175-178

Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies.

Chien KR
Editorial comment: NATURE GENETICS. 2003;33(1):8-9

Cre-constructing the heart.

Ruiz-Lozano P; Chien KR
Review: CELL. 2002;110(2):153-162

Converging pathways and principles in heart development and disease: CV@CSH.

Chien KR; Olson EN
Review: JOURNAL OF CLINICAL INVESTIGATION. 2002;109(7):849-855

Mixed signals in heart failure: cancer rules.

Hoshijima M; Chien KR
Editorial comment: TRENDS IN CARDIOVASCULAR MEDICINE. 2002;12(1):1-2

Something old, something new, something borrowed, something blue: notes on TCM ten years after.

Chien KR
Published conference paper: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2002;67:399-408

The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression.

Hoshijima M; Pashmforoush M; Knöll R; Chien KR
Published conference paper: JOURNAL OF MAGNETIC RESONANCE IMAGING. 2001;14(4):374-382

Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice.

Williams SP; Gerber HP; Giordano FJ; Peale FV; Bernstein LJ; Bunting S; Chien KR; Ferrara N; van Bruggen N
Editorial comment: CIRCULATION RESEARCH. 2001;88(6):546-549

To Cre or not to Cre: the next generation of mouse models of human cardiac diseases.

Chien KR
Review: SEMINARS IN ONCOLOGY. 2000;27(6 Suppl 11):9-14

Myocyte survival pathways and cardiomyopathy: implications for trastuzumab cardiotoxicity.

Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2000;105(10):1339-1342

Meeting Koch's postulates for calcium signaling in cardiac hypertrophy.

Chien KR
Editorial comment: CIRCULATION. 2000;101(13):1616-1618

Mentors for the new millennium : advice to a young cardiologist.

Chien KR
Review: NEW ENGLAND JOURNAL OF MEDICINE. 1999;341(17):1276-1283

Signaling pathways for cardiac hypertrophy and failure.

Hunter JJ; Chien KR
Editorial comment: NATURE MEDICINE. 1999;5(10):1122-1123

Inflammatory pathways and cardiac repair: the affliction of infarction.

Knowlton KU; Chien KR
Review: CELL. 1999;98(5):555-558

Stress pathways and heart failure.

Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(11):1483-1485

Complexity in simplicity: monogenic disorders and complex cardiomyopathies.

Chen J; Chien KR
Editorial comment: CIRCULATION. 1999;99(1):6-7

Good fences make good neighbors : cardiovascular science and medicine at the end of the millenium.

Chien KR
Editorial comment: CIRCULATION. 1997;96(12):4126-4130

Tangled up in blue: molecular cardiology in the postmolecular era.

Pashmforoush M; Chien KR
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 1997;75(7):492-501

Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.

Wollert KC; Chien KR
Review: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;272(6 Pt 2):H2513-H2524

Physiological assessment of complex cardiac phenotypes in genetically engineered mice.

Christensen G; Wang Y; Chien KR
Review: DEVELOPMENT. 1997;124(11):2099-2117

Fashioning the vertebrate heart: earliest embryonic decisions.

Fishman MC; Chien KR
Editorial comment: CIRCULATION. 1997;95(4):766-770

Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research.

Cohn JN; Bristow MR; Chien KR; Colucci WS; Frazier OH; Leinwand LA; Lorell BH; Moss AJ; Sonnenblick EH; Walsh RA; Mockrin SC; Reinlib L
Review: CIRCULATION JOURNAL. 1997;61(2):91-118

Toward molecular strategies for heart disease--past, present, future.

Chien KR; Shimizu M; Hoshijima M; Minamisawa S; Grace AA
Review: JOURNAL OF CARDIAC FAILURE. 1996;2(4 Suppl):S28-S34

A genetic based model of cardiac hypertrophy in MLC-ras mice.

Gottshall KR; Becker KD; Hunter JJ; Chien KR
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 1996;7(1):81-91

Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways.

Pennica D; Wood WI; Chien KR
Published conference paper: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1996;157(1-2):87-91

Expression of cardiac muscle markers in rat myocyte cell lines.

Engelmann GL; Worrell RA; Duff RA; Grutkoski PS; Chien KR; Harvey RP
Published conference paper: HYPERTENSION. 1996;27(3 Pt 2):495-501

Strategies for studying cardiovascular phenotypes in genetically manipulated mice.

Becker KD; Gottshall KR; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(4):901-909

Genes and physiology: molecular physiology in genetically engineered animals.

Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(1):2

Molecular medicine in genetically engineered animals: series introduction.

Chien KR
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 1996;62:143-156

The molecular genetics of retinoic acid receptors: cardiovascular and limb development.

Sucov HM; Lou J; Gruber PJ; Kubalak SW; Dyson E; Gumeringer CL; Lee RY; Moles SA; Chien KR; Giguere V; Evans RM
Editorial comment: CIRCULATION. 1995;92(10):2786-2789

Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates.

Grace AA; Chien KR
Editorial comment: NATURE MEDICINE. 1995;1(8):749-751

Heart and lung disease in engineered mice.

Lin MC; Rockman HA; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1995;96(1):1-3

Close encounters with ET-1.

Chien KR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1995;752:115-127

Signaling pathways for cardiac growth and hypertrophy. Recent advances and prospects for growth factor therapy.

Lembo G; Hunter JJ; Chien KR
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