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•2008-2010 Post-doc in Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Sweden and at Computer Laboratory, University of Cambridge, UK

•2003 PhD in Toxicology, Karolinska Institutet, Sweden

•1998, MSc in Chemistry, Stockholm University, Sweden

Research description

My research is focused on chemical carcinogenesis and on understanding chemicals’ “modes of action” (MOA). We work on methods to improve risk assessment of carcinogens using MOA information. We also study gender differences in chemical carcinogenesis and the mechanisms underlying this.

Text mining for risk assessment and cancer research
In collaboration with computer scientists at the Computer Laboratory, University of Cambridge, UK, we have developed a computerized tool, CRAB, which is based on text-mining. CRAB is an in silico approach, but literature profiles are based on findings in vivo and in vitro. At the heart of the CRAB tool is a taxonomy, which specifies scientific data types of relevance for cancer risk assessment and on the current understanding of the MOAs in carcinogenesis. We are developing this tool with the aim to find new knowledge and hypotheses related to chemical carcinogenesis and cancer risk assessment in large quantities of text.

The CRAB-project:
The Swedish Governmental Agency for Innovation Systems (Vinnova)

Gender differences in carcinogenesis
In this project we investigate sex differences in response to carcinogens. A main objective is to identify chemicals exhibiting sexual dimorphism in their response. Another objective is to identify modes of action for these chemicals. Of special interest is oxidative stress and male susceptibility to carcinogens.

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