David Nelson

About me
Publications
CV
Public outreach and news

About me

Senior consultant in anesthesia and intensive care working at the
neuro-intensive care unit (NICU) at the Karolinska University Hospital, and
conducting my research at Karolinska Institutet.
I am a senior consultant in anesthesia and intensive care working at the
neuro-intensive care unit (NICU) at the Karolinska University Hospital, and
conducting my research at the Department of Physiology and Pharmacology at
Karolinska Institutet.

Research

My research has focused on integrated approaches of interpreting multiple
data streams from brain injury patients. Among other approaches, I have
applied machine learning pattern recognition techniques to data streams from
multi-modal monitoring, particularly cerebral micro-dialysis, and computed
tomography, laboratory values and epidemiological data.
My current research focuses on several aspects of brain injury including
biomarkers, coagulation, dysautonomic reactions and multimodal monitoring. I
am part of the large European FP7 observational study of traumatic brain
injury (CENTER-TBI).

Articles

Article: JOURNAL OF NEUROTRAUMA. 2024;41(5-6):705-713

Absolute Contusion Expansion Is Superior to Relative Expansion in Predicting Traumatic Brain Injury Outcomes: A Multi-Center Observational Cohort Study.

Fletcher-Sandersjöö A; Svedung Wettervik T; Tatter C; Tjerkaski J; Nelson DW; Maegele M; Svensson M; Lewén A; Enblad P; Bellander B-M; Thelin EP
Article: LANCET NEUROLOGY. 2024;23(1):71-80

Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study.

Åkerlund CAI; Holst A; Bhattacharyay S; Stocchetti N; Steyerberg E; Smielewski P; Menon DK; Ercole A; Nelson DW; CENTER-TBI participants and investigators
Article: JOURNAL OF NEUROTRAUMA. 2023;41(7-8):887-909

Therapy Intensity Level Scale for Traumatic Brain Injury: Clinimetric Assessment on Neuro-Monitored Patients Across 52 European Intensive Care Units.

Bhattacharyay S; Beqiri E; Zuercher P; Wilson L; Steyerberg EW; Nelson DW; Maas AIR; Menon DK; Ercole A
Journal article: NEUROCRITICAL CARE. 2023;:1-10

Inaugural State of the Union: Continuous Cerebral Autoregulation Monitoring in the Clinical Practice of Neurocritical Care and Anesthesia.

Park S; Beqiri E; Smielewski P; Aries M; CLINICCA (CLINical use of Information on Continuou
Article: NPJ DIGITAL MEDICINE. 2023;6(1):154

Mining the contribution of intensive care clinical course to outcome after traumatic brain injury.

Bhattacharyay S; Caruso PF; Åkerlund C; Wilson L; Stevens RD; Menon DK; Steyerberg EW; Nelson DW; Ercole A; CENTER-TBI investigators and participants
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2023;11(1):54

The impact of sedative and vasopressor agents on cerebrovascular reactivity in severe traumatic brain injury.

Froese L; Hammarlund E; Åkerlund CAI; Tjerkaski J; Hong E; Lindblad C; Nelson DW; Thelin EP; Zeiler FA
Article: NEUROTRAUMA REPORTS. 2023;4(1):107-117

Time-Dependent Changes in the Biofluid Levels of Neural Injury Markers in Severe Traumatic Brain Injury Patients-Cerebrospinal Fluid and Cerebral Microdialysates: A Longitudinal Prospective Pilot Study.

Lin I-H; Kamnaksh A; Aniceto R; McCullough J; Bekdash R; Eklund M; Ghatan PH; Risling M; Svensson M; Bellander B-M; Nelson DW; Thelin EP; Agoston DV
Article: NEUROCRITICAL CARE. 2023;38(1):60-70

Time Course and Clinical Significance of Hematoma Expansion in Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study.

Fletcher-Sandersjöö A; Tatter C; Tjerkaski J; Bartek J; Maegele M; Nelson DW; Svensson M; Thelin EP; Bellander B-M
Article: CRITICAL CARE AND RESUSCITATION. 2022;24(4):319-329

Early sedation in traumatic brain injury: a multicentre international observational study.

Russo G; Harrois A; Anstey J; Van Der Jagt M; Taccone F; Udy A; Citerio G; Duranteau J; Ichai C; Badenes R; Prowle J; Ercole A; Oddo M; Schneider A; Wolf S; Helbok R; Nelson D; Cooper J; TBI Collaborative Investigators
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(6):2669-2682

A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach.

Cacciani N; Skärlén Å; Wen Y; Zhang X; Addinsall AB; Llano-Diez M; Li M; Gransberg L; Hedström Y; Bellander B-M; Nelson D; Bergquist J; Larsson L
Article: LANCET NEUROLOGY. 2022;21(11):1004-1060

Traumatic brain injury: progress and challenges in prevention, clinical care, and research.

Maas AIR; Menon DK; Manley GT; Abrams M; Åkerlund C; Andelic N; Aries M; Bashford T; Bell MJ; Bodien YG; Brett BL; Büki A; Chesnut RM; Citerio G; Clark D; Clasby B; Cooper DJ; Czeiter E; Czosnyka M; Dams-O'Connor K; De Keyser V; Diaz-Arrastia R; Ercole A; van Essen TA; Falvey É; Ferguson AR; Figaji A; Fitzgerald M; Foreman B; Gantner D; Gao G; Giacino J; Gravesteijn B; Guiza F; Gupta D; Gurnell M; Haagsma JA; Hammond FM; Hawryluk G; Hutchinson P; van der Jagt M; Jain S; Jain S; Jiang J-Y; Kent H; Kolias A; Kompanje EJO; Lecky F; Lingsma HF; Maegele M; Majdan M; Markowitz A; McCrea M; Meyfroidt G; Mikolić A; Mondello S; Mukherjee P; Nelson D; Nelson LD; Newcombe V; Okonkwo D; Orešič M; Peul W; Pisică D; Polinder S; Ponsford J; Puybasset L; Raj R; Robba C; Røe C; Rosand J; Schueler P; Sharp DJ; Smielewski P; Stein MB; von Steinbüchel N; Stewart W; Steyerberg EW; Stocchetti N; Temkin N; Tenovuo O; Theadom A; Thomas I; Espin AT; Turgeon AF; Unterberg A; Van Praag D; van Veen E; Verheyden J; Vyvere TV; Wang KKW; Wiegers EJA; Williams WH; Wilson L; Wisniewski SR; Younsi A; Yue JK; Yuh EL; Zeiler FA; Zeldovich M; Zemek R; InTBIR Participants and Investigators
Article: INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2022;53(8):2774-2782

Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study.

van der Vlegel M; Mikolić A; Lee Hee Q; Kaplan ZLR; Retel Helmrich IRA; van Veen E; Andelic N; Steinbuechel NV; Plass AM; Zeldovich M; Wilson L; Maas AIR; Haagsma JA; Polinder S; CENTER-TBI Participants and Investigators
Article: CRITICAL CARE. 2022;26(1):228

Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study.

Åkerlund CAI; Holst A; Stocchetti N; Steyerberg EW; Menon DK; Ercole A; Nelson DW; CENTER-TBI Participants and Investigators
Article: NPJ DIGITAL MEDICINE. 2022;5(1):96

Dynamic prediction of mortality after traumatic brain injury using a machine learning algorithm.

Raj R; Wennervirta JM; Tjerkaski J; Luoto TM; Posti JP; Nelson DW; Takala R; Bendel S; Thelin EP; Luostarinen T; Korja M
Article: ANNALS OF INTENSIVE CARE. 2022;12(1):62

Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study.

Mele A; Cerminara E; Häbel H; Rodriguez-Galvez B; Oldner A; Nelson D; Gårdh J; Thobaben R; Jonmarker S; Cronhjort M; Hollenberg J; Mårtensson J
Article: ACTA NEUROCHIRURGICA. 2022;164(7):1693-1705

Comparative effectiveness of intracranial hypertension management guided by ventricular versus intraparenchymal pressure monitoring: a CENTER-TBI study.

Volovici V; Pisică D; Gravesteijn BY; Dirven CMF; Steyerberg EW; Ercole A; Stocchetti N; Nelson D; Menon DK; Citerio G; van der Jagt M; Maas AIR; Haitsma IK; Lingsma HF; CENTER-TBI investigators, participants for the ICU
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2022;66(6):759-766

The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors.

Nelson DW; Granberg T; Andersen P; Jokhadar E; Kåhlin J; Granström A; Hallinder H; Schening A; Thunborg C; Walles H; Hagman G; Shams-Latifi R; Yu J; Petersson S; Tzortzakakis A; Levak N; Aspö M; Piehl F; Zetterberg H; Kivipelto M; Eriksson LI
Journal article: FASEB JOURNAL. 2022;36(S1)

A prospective clinical study on the mechanisms underlying Critical Illness Myopathy – A time‐course approach

Larsson L; Cacciani N; Skärlén Å; Wen Y; Wang X; Addinsall AB; Llano‐Diez M; Li M; Gransberg L; Hedström Y; Bellander B; Nelson D; Bergquist J
Article: JOURNAL OF NEUROTRAUMA. 2022;39(1-2):58-66

Extended Analysis of Axonal Injuries Detected Using Magnetic Resonance Imaging in Critically Ill Traumatic Brain Injury Patients.

Tjerkaski J; Nyström H; Raj R; Lindblad C; Bellander B-M; Nelson DW; Thelin EP
Article: PLOS ONE. 2022;17(7):e0270973

The leap to ordinal: Detailed functional prognosis after traumatic brain injury with a flexible modelling approach.

Bhattacharyay S; Milosevic I; Wilson L; Menon DK; Stevens RD; Steyerberg EW; Nelson DW; Ercole A; CENTER-TBI investigators participants
Journal article: ALZHEIMERS & DEMENTIA. 2021;17(Suppl 6):e055939

Neuro‐COVID: Does severe COVID‐19 infection increase the risk for cognitive impairment?

Hagman G; Thunborg C; Andersen P; Levak N; Aspö M; Walles H; Jokhader E; Kåhlin J; Nelson D; Piehl F; Tzortzakakis A; Zetterberg H; Granberg T; Eriksson LI; Kivipelto M
Article: ACTA OTO-LARYNGOLOGICA. 2021;141(10):953-959

Navigation system for percutaneous tracheotomy.

Ullman J; Karling J; Bark R; Nelson D; Wanecek M; Margolin G
Article: CRITICAL CARE. 2021;25(1):291

Cerebrospinal fluid cell count variability is a major confounding factor in external ventricular drain-associated infection surveillance diagnostics: a prospective observational study.

Bådholm M; Blixt J; Glimåker M; Ternhag A; Hedlund J; Nelson DW
Article: NEUROCRITICAL CARE. 2021;34(3):899-907

Variability in Serum Sodium Concentration and Prognostic Significance in Severe Traumatic Brain Injury: A Multicenter Observational Study.

Harrois A; Anstey JR; van der Jagt M; Taccone FS; Udy AA; Citerio G; Duranteau J; Ichai C; Badenes R; Prowle JR; Ercole A; Oddo M; Schneider A; Wolf S; Helbok R; Nelson DW; Cooper DJ; Bellomo R; TBI Collaborative
Article: CRITICAL CARE. 2021;25(1):165

Temporal patterns of organ dysfunction after severe trauma.

Eriksson J; Nelson D; Holst A; Hellgren E; Friman O; Oldner A
Article: CRITICAL CARE. 2021;25(1):78

Use and impact of high intensity treatments in patients with traumatic brain injury across Europe: a CENTER-TBI analysis.

Huijben JA; Dixit A; Stocchetti N; Maas AIR; Lingsma HF; van der Jagt M; Nelson D; Citerio G; Wilson L; Menon DK; Ercole A; CENTER-TBI investigators and participants
Article: PLOS ONE. 2021;16(8):e0253425

Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury: A CENTER-TBI study.

Ercole A; Dixit A; Nelson DW; Bhattacharyay S; Zeiler FA; Nieboer D; Bouamra O; Menon DK; Maas AIR; Dijkland SA; Lingsma HF; Wilson L; Lecky F; Steyerberg EW; CENTER-TBI Investigators and Participants
Article: ACTA NEUROCHIRURGICA. 2020;162(11):2695-2706

Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury: a CENTER-TBI exploratory study.

Zeiler FA; Ercole A; Cabeleira M; Stocchetti N; Hutchinson PJ; Smielewski P; Czosnyka M; CENTER-TBI High Resolution (HR ICU) Sub-Study Part
Article: JOURNAL OF CRITICAL CARE. 2020;59:6-15

Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study.

van Wijk RPJ; van Dijck JTJM; Timmers M; van Veen E; Citerio G; Lingsma HF; Maas AIR; Menon DK; Peul WC; Stocchetti N; Kompanje EJO; CENTER-TBI investigators and participants
Article: JOURNAL OF CLINICAL MONITORING AND COMPUTING. 2020;34(5):971-994

Comparison of high versus low frequency cerebral physiology for cerebrovascular reactivity assessment in traumatic brain injury: a multi-center pilot study.

Thelin EP; Raj R; Bellander B-M; Nelson D; Piippo-Karjalainen A; Siironen J; Tanskanen P; Hawryluk G; Hasen M; Unger B; Zeiler FA
Article: JOURNAL OF NEUROTRAUMA. 2020;37(12):1381-1391

Influence of Blood-Brain Barrier Integrity on Brain Protein Biomarker Clearance in Severe Traumatic Brain Injury: A Longitudinal Prospective Study.

Lindblad C; Nelson DW; Zeiler FA; Ercole A; Ghatan PH; von Horn H; Risling M; Svensson M; Agoston DV; Bellander B-M; Thelin EP
Article: JOURNAL OF CLINICAL EPIDEMIOLOGY. 2020;122:95-107

Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury.

Gravesteijn BY; Nieboer D; Ercole A; Lingsma HF; Nelson D; van Calster B; Steyerberg EW; CENTER-TBI collaborators
Article: JOURNAL OF NEUROTRAUMA. 2020;37(10):1233-1241

Association between Cerebrovascular Reactivity Monitoring and Mortality Is Preserved When Adjusting for Baseline Admission Characteristics in Adult Traumatic Brain Injury: A CENTER-TBI Study.

Zeiler FA; Ercole A; Beqiri E; Cabeleira M; Thelin EP; Stocchetti N; Steyerberg EW; Maas AIR; Menon DK; Czosnyka M; Smielewski P; CENTER-TBI High Resolution ICU (HR ICU) Sub-Study
Article: INTENSIVE CARE MEDICINE. 2020;46(5):995-1004

Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe: a CENTER-TBI analysis.

Huijben JA; Wiegers EJA; Lingsma HF; Citerio G; Maas AIR; Menon DK; Ercole A; Nelson D; van der Jagt M; Steyerberg EW; Helbok R; Lecky F; Peul W; Birg T; Zoerle T; Carbonara M; Stocchetti N; CENTER-TBI investigators and participants
Article: JOURNAL OF NEUROTRAUMA. 2020;37(7):1002-1010

Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study.

Gravesteijn BY; Sewalt CA; Ercole A; Akerlund C; Nelson D; Maas AIR; Menon D; Lingsma HF; Steyerberg EW; Collaborative European NeuroTrauma Effectiveness R
Article: JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE. 2020;4(4):354-359

Guidelines for Data Acquisition, Quality and Curation for Observational Research Designs (DAQCORD).

Ercole A; Brinck V; George P; Hicks R; Huijben J; Jarrett M; Vassar M; Wilson L; DAQCORD collaborators
Article: FRONTIERS IN NEUROLOGY. 2020;11:610192

Delayed Neurosurgical Intervention in Traumatic Brain Injury Patients Referred From Primary Hospitals Is Not Associated With an Unfavorable Outcome.

Grevfors N; Lindblad C; Nelson DW; Svensson M; Thelin EP; Rubenson Wahlin R
Article: PLOS ONE. 2020;15(12):e0243427

Impact of duration and magnitude of raised intracranial pressure on outcome after severe traumatic brain injury: A CENTER-TBI high-resolution group study.

Åkerlund CA; Donnelly J; Zeiler FA; Helbok R; Holst A; Cabeleira M; Güiza F; Meyfroidt G; Czosnyka M; Smielewski P; Stocchetti N; Ercole A; Nelson DW; CENTER-TBI High Resolution ICU Sub-Study Participa
Article: JOURNAL OF NEUROTRAUMA. 2020;37(1):178-184

Early Osmotherapy in Severe Traumatic Brain Injury: An International Multicenter Study.

Anstey JR; Taccone FS; Udy AA; Citerio G; Duranteau J; Ichai C; Badenes R; Prowle JR; Ercole A; Oddo M; Schneider AG; van der Jagt M; Wolf S; Helbok R; Nelson DW; Skrifvars MB; Harrois A; Presneill J; Cooper DJ; Bailey M; Bellomo R; TBI Collaborative
Article: ACTA NEUROCHIRURGICA. 2019;161(12):2467-2478

Prognostic performance of computerized tomography scoring systems in civilian penetrating traumatic brain injury: an observational study.

Lindfors M; Lindblad C; Nelson DW; Bellander B-M; Siironen J; Raj R; Thelin EP
Article: JOURNAL OF NEUROTRAUMA. 2019;36(20):2850-2862

A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury.

Thelin E; Al Nimer F; Frostell A; Zetterberg H; Blennow K; Nyström H; Svensson M; Bellander B-M; Piehl F; Nelson DW
Article: LANCET NEUROLOGY. 2019;18(10):923-934

Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study.

Steyerberg EW; Wiegers E; Sewalt C; Buki A; Citerio G; De Keyser V; Ercole A; Kunzmann K; Lanyon L; Lecky F; Lingsma H; Manley G; Nelson D; Peul W; Stocchetti N; von Steinbüchel N; Vande Vyvere T; Verheyden J; Wilson L; Maas AIR; Menon DK; CENTER-TBI Participants and Investigators
Article: ANNALS OF INTENSIVE CARE. 2019;9(1):99

Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study.

Harrois A; Anstey JR; Taccone FS; Udy AA; Citerio G; Duranteau J; Ichai C; Badenes R; Prowle JR; Ercole A; Oddo M; Schneider A; van der Jagt M; Wolf S; Helbok R; Nelson DW; Skrifvars MB; Cooper DJ; Bellomo R; TBI Collaborative
Article: ACTA NEUROCHIRURGICA. 2019;161(9):1955-1964

Cerebrovascular reactivity is not associated with therapeutic intensity in adult traumatic brain injury: a CENTER-TBI analysis.

Zeiler FA; Ercole A; Beqiri E; Cabeleira M; Aries M; Zoerle T; Carbonara M; Stocchetti N; Smielewski P; Czosnyka M; Menon DK; CENTER-TBI High Resolution ICU (HR ICU) Sub-Study
Journal article: 2019

Machine Learning for Prediction of Mortality and Unfavorable Outcome in Traumatic Brain Injury: A CENTER-TBI Study

Gravesteijn B; Nieboer D; Ercole A; Lingsma HF; Nelson D; van Calster B; Steyerberg EW; Collaborators C-T
Article: ACTA NEUROCHIRURGICA. 2019;161(7):1275-1284

Compensatory-reserve-weighted intracranial pressure versus intracranial pressure for outcome association in adult traumatic brain injury: a CENTER-TBI validation study.

Zeiler FA; Ercole A; Cabeleira M; Beqiri E; Zoerle T; Carbonara M; Stocchetti N; Menon DK; Smielewski P; Czosnyka M; CENTER-TBI High Resolution ICU Sub-Study Participa
Article: JOURNAL OF NEUROTRAUMA. 2019;36(11):1724-1737

How to Translate Time: The Temporal Aspects of Rodent and Human Pathobiological Processes in Traumatic Brain Injury.

Agoston DV; Vink R; Helmy A; Risling M; Nelson D; Prins M
Article: ACTA NEUROCHIRURGICA. 2019;161(6):1217-1227

Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI: a CENTER-TBI study.

Zeiler FA; Ercole A; Cabeleira M; Zoerle T; Stocchetti N; Menon DK; Smielewski P; Czosnyka M; CENTER-TBI High Resolution Sub-Study Participants
Article: NEUROCRITICAL CARE. 2019;30(3):590-600

The Role of Glycerol-Containing Drugs in Cerebral Microdialysis: A Retrospective Study on the Effects of Intravenously Administered Glycerol.

Forssten MP; Thelin EP; Nelson DW; Bellander B-M
Article: JOURNAL OF NEUROTRAUMA. 2019;36(10):1505-1517

Comparison of Performance of Different Optimal Cerebral Perfusion Pressure Parameters for Outcome Prediction in Adult Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study.

Zeiler FA; Ercole A; Cabeleira M; Carbonara M; Stocchetti N; Menon DK; Smielewski P; Czosnyka M; CENTER-TBI High Resolution (HR ICU) Sub-Study Part
Article: WORLD NEUROSURGERY. 2019;125:e515-e520

Variation in Guideline Implementation and Adherence Regarding Severe Traumatic Brain Injury Treatment: A CENTER-TBI Survey Study in Europe.

Volovici V; Ercole A; Citerio G; Stocchetti N; Haitsma IK; Huijben JA; Dirven CMF; van der Jagt M; Steyerberg EW; Nelson D; Cnossen MC; Maas AIR; Polinder S; Menon DK; Lingsma HF; CENTER-TBI collaborators
Article: CRITICAL CARE. 2019;23(1):95

Development of a quality indicator set to measure and improve quality of ICU care for patients with traumatic brain injury.

Huijben JA; Wiegers EJA; de Keizer NF; Maas AIR; Menon D; Ercole A; Citerio G; Lecky F; Wilson L; Cnossen MC; Polinder S; Steyerberg EW; van der Jagt M; Lingsma HF; Delphi panel
Article: JOURNAL OF CRITICAL CARE. 2019;49:158-161

Intensive care admission criteria for traumatic brain injury patients across Europe.

Volovici V; Ercole A; Citerio G; Stocchetti N; Haitsma IK; Huijben JA; Dirven CMF; van der Jagt M; Steyerberg EW; Nelson D; Cnossen MC; Maas AIR; Polinder S; Menon DK; Lingsma HF
Article: ANESTHESIOLOGY. 2018;129(4):769-777

Standardized Unloading of Respiratory Muscles during Neurally Adjusted Ventilatory Assist: A Randomized Crossover Pilot Study.

Campoccia Jalde F; Jalde F; Wallin MKEB; Suarez-Sipmann F; Radell PJ; Nelson D; Eksborg S; Sackey PV
Article: CRITICAL CARE. 2018;22(1):90

Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study.

Huijben JA; Volovici V; Cnossen MC; Haitsma IK; Stocchetti N; Maas AIR; Menon DK; Ercole A; Citerio G; Nelson D; Polinder S; Steyerberg EW; Lingsma HF; van der Jagt M; CENTER-TBI investigators and participants
Article: FRONTIERS IN NEUROLOGY. 2018;9:15

Assessment of Platelet Function in Traumatic Brain Injury-A Retrospective Observational Study in the Neuro-Critical Care Setting.

Lindblad C; Thelin EP; Nekludov M; Frostell A; Nelson DW; Svensson M; Bellander B-M
Article: FRONTIERS IN NEUROLOGY. 2018;9:194

Prehospital Intubation and Outcome in Traumatic Brain Injury-Assessing Intervention Efficacy in a Modern Trauma Cohort.

Rubenson Wahlin R; Nelson DW; Bellander B-M; Svensson M; Helmy A; Thelin EP
Article: CRITICAL CARE. 2017;21(1):233

Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study.

Cnossen MC; Huijben JA; van der Jagt M; Volovici V; van Essen T; Polinder S; Nelson D; Ercole A; Stocchetti N; Citerio G; Peul WC; Maas AIR; Menon D; Steyerberg EW; Lingsma HF; CENTER-TBI investigators
Article: PLOS MEDICINE. 2017;14(8):e1002368

Evaluation of novel computerized tomography scoring systems in human traumatic brain injury: An observational, multicenter study.

Thelin EP; Nelson DW; Vehviläinen J; Nyström H; Kivisaari R; Siironen J; Svensson M; Skrifvars MB; Bellander B-M; Raj R
Article: CRITICAL CARE. 2016;20:285

Utility of neuron-specific enolase in traumatic brain injury; relations to S100B levels, outcome, and extracranial injury severity.

Thelin EP; Jeppsson E; Frostell A; Svensson M; Mondello S; Bellander B-M; Nelson DW
Article: BMC NEUROLOGY. 2016;16:93

Kinetic modelling of serum S100b after traumatic brain injury.

Ercole A; Thelin EP; Holst A; Bellander BM; Nelson DW
Article: NEUROSURGERY. 2015;76(1):67-80

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

Maas AIR; Menon DK; Steyerberg EW; Citerio G; Lecky F; Manley GT; Hill S; Legrand V; Sorgner A; CENTER-TBI Participants and Investigators
Article: PLOS ONE. 2015;10(7):e0132177

Comparative Assessment of the Prognostic Value of Biomarkers in Traumatic Brain Injury Reveals an Independent Role for Serum Levels of Neurofilament Light.

Al Nimer F; Thelin E; Nyström H; Dring AM; Svenningsson A; Piehl F; Nelson DW; Bellander B-M
Article: NEUROCRITICAL CARE. 2014;20(2):217-229

Secondary peaks of S100B in serum relate to subsequent radiological pathology in traumatic brain injury.

Thelin EP; Nelson DW; Bellander B-M
Article: FRONTIERS IN NEUROLOGY. 2014;5:159

Microdialysis Monitoring of CSF Parameters in Severe Traumatic Brain Injury Patients: A Novel Approach.

Thelin EP; Nelson DW; Ghatan PH; Bellander B-M
Article: JOURNAL OF NEUROTRAUMA. 2013;30(7):519-528

S100B is an important outcome predictor in traumatic brain injury.

Thelin EP; Johannesson L; Nelson D; Bellander B-M
Article: JOURNAL OF NEUROTRAUMA. 2012;29(17):2613-2624

Multivariate outcome prediction in traumatic brain injury with focus on laboratory values.

Nelson DW; Rudehill A; MacCallum RM; Holst A; Wanecek M; Weitzberg E; Bellander B-M
Article: BMC MEDICINE. 2011;9:21

Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement.

Nelson DW; Thornquist B; MacCallum RM; Nyström H; Holst A; Rudehill A; Wanecek M; Bellander B-M; Weitzberg E
Article: JOURNAL OF NEUROTRAUMA. 2010;27(1):51-64

Extended analysis of early computed tomography scans of traumatic brain injured patients and relations to outcome.

Nelson DW; Nyström H; MacCallum RM; Thornquist B; Lilja A; Bellander B-M; Rudehill A; Wanecek M; Weitzberg E
Article: CRITICAL CARE MEDICINE. 2004;32(12):2428-2436

Cerebral microdialysis of patients with severe traumatic brain injury exhibits highly individualistic patterns as visualized by cluster analysis with self-organizing maps.

Nelson DW; Bellander B-M; Maccallum RM; Axelsson J; Alm M; Wallin M; Weitzberg E; Rudehill A
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 1998;42(5):551-557

Increased platelet microvesicle formation is associated with mortality in a porcine model of endotoxemia.

Eriksson M; Nelson D; Nordgren A; Larsson A
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 1997;41(7):824-829

Vitamin A exerts potential therapeutic effects in the endotoxaemic pig.

Eriksson M; Lundkvist K; Larsson A; Nelson D; Saldeen T; Drott P; Eriksson O
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All other publications

Editorial comment: NEUROCRITICAL CARE. 2024;40(2):391-394

A Solution to the Cerebral Perfusion Pressure Transducer Placement Conundrum in Neurointensive Care? The Dual Transducer.

Mikkonen E; Blixt J; Ercole A; Alpkvist P; Sköldbring R; Bellander B-M; Weitzberg E; Nelson DW
Preprint: MEDRXIV. 2023

The Therapy Intensity Level scale for traumatic brain injury: clinimetric assessment on neuro-monitored patients across 52 European intensive care units

Bhattacharyay S; Beqiri E; Zuercher P; Wilson L; Steyerberg EW; Nelson DW; Maas AIR; Menon DK; Ercole A; investigators and participants C-T
Preprint: ARXIV. 2023

Mining the contribution of intensive care clinical course to outcome after traumatic brain injury

Bhattacharyay S; Caruso PF; Åkerlund C; Wilson L; Stevens RD; Menon DK; Steyerberg EW; Nelson DW; Ercole A; investigators/participants TC-T
Preprint: ARXIV. 2022

The leap to ordinal: detailed functional prognosis after traumatic brain injury with a flexible modelling approach

Bhattacharyay S; Milosevic I; Wilson L; Menon DK; Stevens RD; Steyerberg EW; Nelson DW; Ercole A; investigators/participants TC-T
Conference publication: JOURNAL OF NEUROTRAUMA. 2022;39(11-12):A107

TRAUMATIC BRAIN INJURY PATIENT TRAJECTORIES IN THE ICU: FULL-CONTEXT MODELLING WITH ARTIFICIAL INTELLIGENCE FOR DYNAMIC ORDINAL PROGNOSES

Bhattacharyay S; Deasy J; Wilson L; Menon D; Stevens R; Steyerberg E; Nelson D; Ercole A
Conference publication: JOURNAL OF NEUROTRAUMA. 2022;39(15-16):A10

MULTI-COMPARTMENTAL METABOLIC DYNAMICS FOLLOWING SEVERE TRAUMATIC BRAIN INJURY HIGHLIGHT THE NECESSITY OF FOCAL MONITORING

Hammarlund E; Lindblad C; Akerlund C; Bellander BM; Nelson D; Thelin E
Preprint: RESEARCH SQUARE. 2021

Clinical Impact of Hemorrhagic Lesion Progression Following Moderate-to-Severe Traumatic Brain Injury: An Observational Cohort Study

Fletcher-Sandersjöö A; Tatter C; Tjerkaski J; Bartek J; Maegele M; Nelson D; Svensson M; Thelin EP; Bellander B-M
Preprint: MEDRXIV. 2021

Imputation strategies for missing baseline neurological assessment covariates after traumatic brain injury: A CENTER-TBI study

Ercole A; Dixit A; Nelson DW; Zeiler FA; Nieboer D; Bouamra O; Menon DK; Maas AI; Dijkland SA; Lingsma HF; Wilson L; Lecky F; Steyerberg E; Investigators and Participants C-T
Preprint: RESEARCH SQUARE. 2021

Extended analysis of axonal injuries detected using magnetic resonance imaging and their relation to outcome in critically ill traumatic brain injury patients

Tjerkaski J; Nyström H; Raj R; Lindblad C; Bellander B-M; Nelson DW; Thelin EP
Preprint: RESEARCH SQUARE. 2020

Use and Impact of High Intensity Treatments in Patients with Traumatic Brain Injury Across Europe: A CENTER-TBI Analysis

Huijben J; Dixit A; Stocchetti N; Maas A; Lingsma H; Jagt MVD; Nelson D; Citerio G; Wilson L; Menon D; Ercole A
Book chapter: MANAGEMENT OF SEVERE TRAUMATIC BRAIN INJURY. 2020;p. 343-355

Serum Protein Biomarkers in the Management of Severe Traumatic Brain Injury

Thelin EP; Nelson DW; Undén J; Åstrand R; Bellander B-M
Corrigendum: ANNALS OF INTENSIVE CARE. 2019;9(1):136

Correction to: Serum sodium and intracranial pressure changes after desmopressin therapy in severe traumatic brain injury patients: a multi-centre cohort study.

Harrois A; Anstey JR; Taccone FS; Udy AA; Citerio G; Duranteau J; Ichai C; Badenes R; Prowle JR; Ercole A; Oddo M; Schneider A; van der Jagt M; Wolf S; Helbok R; Nelson DW; Skrifvars MB; Cooper DJ; Bellomo R; TBI Collaborative
Corrigendum: ACTA NEUROCHIRURGICA. 2019;161(3):451-455

Correction to: Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study.

van Essen TA; den Boogert HF; Cnossen MC; de Ruiter GCW; Haitsma I; Polinder S; Steyerberg EW; Menon D; Maas AIR; Lingsma HF; Peul WC; CENTER-TBI Investigators and Participants
Preprint: SSRN ELECTRONIC JOURNAL. 2019

Machine Learning for Prediction of Mortality and Unfavorable Outcome in Traumatic Brain Injury: A CENTER-TBI Study

Gravesteijn B; Nieboer D; Ercole A; Lingsma HF; Nelson D; van Calster B; Steyerberg EW; Collaborators C-T
Editorial comment: FRONTIERS IN NEUROLOGY. 2018;9:193

Editorial: Monitoring Pathophysiology in the Injured Brain.

Thelin EP; Helmy A; Nelson DW; Marklund N
Conference publication: JOURNAL OF NEUROTRAUMA. 2018;35(16):A77

INTRACRANIAL VERSUS EXTRACRANIAL CHANGES IN PROTEIN BIOMARKER LEVELS IN EXPERIMENTAL AND CLINICAL TBI STUDIES

Agoston DV; Thelin EP; Bellander B-M; Nelson DW; Ahmed F; Gyorgyi A; Tong L; Kamnaksh A
Conference publication: JOURNAL OF NEUROTRAUMA. 2018;35(16):A126-A127

TRAJECTORY CLUSTERING USING LATENT CLASS MODELS FOR UNSUPERVISED TBI BIOMARKER TEMPORAL PHENOTYPE DISCOVER

Ercole A; Lindblad C; Nelson DW; Risling M; Svensson M; Bellander B-M; Thelin EP; Dixit A
Conference publication: JOURNAL OF NEUROTRAUMA. 2018;35(16):A235

INFLUENCE OF BLOOD-BRAIN BARRIER INTEGRITY ON BIOMARKER FLUX BETWEEN DIFFERENT COMPARTMENTS FOLLOWING TRAUMATIC BRAIN INJURY

Lindblad C; Nelson DW; Ercole A; Ghatan PH; Risling M; Svensson M; Agoston DV; Bellander B-M; Thelin EP
Review: LANCET NEUROLOGY. 2017;16(12):987-1048

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research.

Maas AIR; Menon DK; Adelson PD; Andelic N; Bell MJ; Belli A; Bragge P; Brazinova A; Büki A; Chesnut RM; Citerio G; Coburn M; Cooper DJ; Crowder AT; Czeiter E; Czosnyka M; Diaz-Arrastia R; Dreier JP; Duhaime A-C; Ercole A; van Essen TA; Feigin VL; Gao G; Giacino J; Gonzalez-Lara LE; Gruen RL; Gupta D; Hartings JA; Hill S; Jiang J-Y; Ketharanathan N; Kompanje EJO; Lanyon L; Laureys S; Lecky F; Levin H; Lingsma HF; Maegele M; Majdan M; Manley G; Marsteller J; Mascia L; McFadyen C; Mondello S; Newcombe V; Palotie A; Parizel PM; Peul W; Piercy J; Polinder S; Puybasset L; Rasmussen TE; Rossaint R; Smielewski P; Söderberg J; Stanworth SJ; Stein MB; von Steinbüchel N; Stewart W; Steyerberg EW; Stocchetti N; Synnot A; Te Ao B; Tenovuo O; Theadom A; Tibboel D; Videtta W; Wang KKW; Williams WH; Wilson L; Yaffe K; InTBIR Participants and Investigators
Review: ACTA NEUROCHIRURGICA. 2017;159(2):209-225

A review of the clinical utility of serum S100B protein levels in the assessment of traumatic brain injury.

Thelin EP; Nelson DW; Bellander B-M
Review: FRONTIERS IN NEUROLOGY. 2017;8:300

Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review.

Thelin EP; Zeiler FA; Ercole A; Mondello S; Büki A; Bellander B-M; Helmy A; Menon DK; Nelson DW
Conference publication: JOURNAL OF NEUROTRAUMA. 2017;34(13):A124

PREHOSPITAL ADVANCED AIRWAY MANAGEMENT IN TRAUMATIC BRAIN INJURY AND ITS RELATION TO OUTCOME

Wahlin RR; Nelson DW; Bellander B-M; Svensson M; Thelin E
Letter: CRITICAL CARE. 2016;20:376

The utility of biomarkers in traumatic brain injury clinical management

Peter Thelin E; Jeppsson E; Bellander B-M; Nelson DW
Conference publication: JOURNAL OF NEUROTRAUMA. 2016;33(3):A39

BAYESIAN MODEL OF TRAUMATIC BRAIN INJURY BIOMARKER KINETICS

Ercole A; Thelin E; Holst A; Bellander B; Nelson D
Conference publication: JOURNAL OF NEUROTRAUMA. 2015;32(12):A30

NEURON-SPECIFIC ENOLASE IS SIGNIFICANTLY CORRELATED TO OUTCOME POST TRAUMATIC BRAIN INJURY, ALBEIT NOT IN PRESENCE OF SERUM S100B

Thelin E; Jeppsson E; Nelson D; Mondello S; Svensson M; Bellander B-M
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Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2026

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Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2010
University Medical Degree, Karolinska Institutet, 1991

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