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Cristina Morganti-Kossmann

Associated

Visiting address : Dep of Neurosurgery, R2:02, 17176 Stockholm, Sweden
Postal address : Department of Clinical Neuroscience (CNS), K8, Neuro Svensson, C/o Bellander, Lill-Jansplan 5, 11425 Stockholm, Sweden
Delivery address : Dep of Neurosurgery, R2:02, 17176 Stockholm, Sweden

Publications

The role of markers of inflammation in traumatic brain injury
Woodcock T, Morganti-kossmann Mc
Frontiers in neurology 2013;4():18-

Attenuation of Microglial Activation with Minocycline Is Not Associated with Changes in Neurogenesis after Focal Traumatic Brain Injury in Adult Mice
Ng Sy, Semple Bd, Morganti-kossmann Mc, Bye N
JOURNAL OF NEUROTRAUMA 2012;29(7):1410-25

Early management of severe traumatic brain injury
Rosenfeld Jv, Maas Ai, Bragge P, Morganti-kossmann Mc, Manley Gt, Gruen Rl
LANCET 2012;380(9847):1088-98

Guilty Molecules, Guilty Minds? The Conflicting Roles of the Innate Immune Response to Traumatic Brain Injury
Hellewell Sc, Morganti-kossmann Mc
MEDIATORS OF INFLAMMATION 2012;:356494-

Inflammatory Regulators of Redirected Neural Migration in the Injured Brain
Bye N, Turnley Am, Morganti-kossmann Mc
NEUROSIGNALS 2012;20(3):132-46

Sensory Cortex Underpinnings of Traumatic Brain Injury Deficits
Alwis Ds, Yan Eb, Morganti-kossmann Mc, Rajan R
PLOS ONE 2012;7(12):e52169-

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans
Sashindranath M, Sales E, Daglas M, Freeman R, Samson Al, Cops Ej, et al
BRAIN 2012;:3251-64

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury
Ziebell Jm, Bye N, Semple Bd, Kossmann T, Morganti-kossmann Mc
BRAIN RESEARCH 2011;:94-105

Neurogenesis and Glial Proliferation Are Stimulated Following Diffuse Traumatic Brain Injury in Adult Rats
Bye N, Carron S, Han Xd, Agyapomaa D, Ng Sy, Yan E, et al
JOURNAL OF NEUROSCIENCE RESEARCH 2011;89(7):986-1000

Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury
Yan Eb, Hellewell Sc, Bellander Bm, Agyapomaa Da, Morganti-kossmann Mc
JOURNAL OF NEUROINFLAMMATION 2011;:147-

Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory?
Morganti-kossmann Mc, Yan E, Bye N
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED 2010;:S10-3

CCL2 modulates cytokine production in cultured mouse astrocytes
Semple Bd, Frugier T, Morganti-kossmann Mc
JOURNAL OF NEUROINFLAMMATION 2010;:67-

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury
Semple Bd, Bye N, Ziebell Jm, Morganti-kossmann Mc
NEUROBIOLOGY OF DISEASE 2010;40(2):394-403

In Situ Detection of Inflammatory Mediators in Post Mortem Human Brain Tissue after Traumatic Injury
Frugier T, Morganti-kossmann Mc, O'reilly D, Mclean Ca
JOURNAL OF NEUROTRAUMA 2010;27(3):497-507

Involvement of Pro- and Anti-Inflammatory Cytokines and Chemokines in the Pathophysiology of Traumatic Brain Injury
Ziebell Jm, Morganti-kossmann Mc
NEUROTHERAPEUTICS 2010;7(1):22-30

Post-Traumatic Hypoxia Exacerbates Brain Tissue Damage: Analysis of Axonal Injury and Glial Responses
Hellewell Sc, Yan Eb, Agyapomaa Da, Bye N, Morganti-kossmann Mc
JOURNAL OF NEUROTRAUMA 2010;27(11):1997-2010

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice
Semple Bd, Bye N, Rancan M, Ziebell Jm, Morganti-kossmann Mc
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2010;30(4):769-82

Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks
Semple Bd, Kossmann T, Morganti-kossmann Mc
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2010;30(3):459-73

Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray
Seifman Ma, Adamides Aa, Nguyen Pn, Vallance Sa, Cooper Dj, Kossmann T, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2008;28(4):684-96

Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice
Habgood Md, Bye N, Dziegielewska Km, Ek Cj, Lane Ma, Potter A, et al
EUROPEAN JOURNAL OF NEUROSCIENCE 2007;25(1):231-8

Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: Relationship with neuronal cell death and inflammatory mediators
Grosjean Mb, Lenzlinger Pm, Stahel Pf, Yatsiv I, Shohami E, Trentz O, et al
HISTOLOGY AND HISTOPATHOLOGY 2007;22(3):235-50

Modulation of immune response by head injury
Morganti-kossmann Mc, Satgunaseelan L, Bye N, Kossmann T
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED 2007;38(12):1392-400

Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration
Bye N, Habgood Md, Callaway Jk, Malakooti N, Potter A, Kossmann T, et al
EXPERIMENTAL NEUROLOGY 2007;204(1):220-33

Activin A release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury
Phillips Dj, Nguyen P, Adamides Aa, Bye N, Rosenfeld Jv, Kossmann T, et al
JOURNAL OF NEUROTRAUMA 2006;23(9):1283-94

Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats
Lenzlinger Pm, Shimizu S, Marklund N, Thompson Hj, Schwab Me, Saatman Ke, et al
NEUROSCIENCE 2005;134(3):1047-56

The chemokine fractalkine in patients with severe traumatic brain injury and a mouse model of closed head injury
Rancan M, Bye N, Otto Vi, Trentz O, Kossmann T, Frentzel S, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2004;24(10):1110-8

Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice
Rancan M, Morganti-kossmann Mc, Barnum Tr, Saft T, Schmidt Toi, Ertel Wg, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2003;23(9):1070-4

Cytomegalovirus production by infected astrocytes correlates with transforming growth factor-beta release
Kossmann T, Morganti-kossmann Mc, Orenstein Jm, Britt Wj, Wahl Sm, Smith Pd
JOURNAL OF INFECTIOUS DISEASES 2003;187(4):534-41

Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury
Yatsiv I, Morganti-kossmann Mc, Perez D, Dinarello Ca, Novick D, Rubinstein M, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2002;22(8):971-8

Inflammatory response in acute traumatic brain injury: a double-edged sword
Morganti-kossmann Mc, Rancan M, Stahel Pf, Kossmann T
Current opinion in critical care 2002;8(2):101-5

Prolonged intrathecal release of soluble Fas following severe traumatic brain injury in humans
Lenzlinger Pm, Marx A, Trentz O, Kossmann T, Morganti-kossmann Mc
JOURNAL OF NEUROIMMUNOLOGY 2002;122(1-2):167-74

The production of macrophage inflammatory protein-2 induced by soluble intercellular adhesion molecule-1 in mouse astrocytes is mediated by src tyrosine kinases and p42/44 mitogen-activated protein kinase
Otto Vi, Gloor Sm, Frentzel S, Gilli U, Ammann E, Hein Ae, et al
JOURNAL OF NEUROCHEMISTRY 2002;80(5):824-34

Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury
Stahel Pf, Morganti-kossmann Mc, Perez D, Redaelli C, Gloor B, Trentz O, et al
JOURNAL OF NEUROTRAUMA 2001;18(8):773-81

Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans
Lenzlinger Pm, Hans Vhj, Joller-jemelka Hi, Trentz O, Morganti-kossmann Mc, Kossmann T
JOURNAL OF NEUROTRAUMA 2001;18(5):479-89

New trends in trauma research. Results of a meeting at the Schloss Reisensburg 27./28.02.2000
Gebhard F, Liener Uc, Obertacke U, Morganti-kossmann Mc, Bruckner Ub, Kinzl L
UNFALLCHIRURG 2001;104(4):365-8

Role of cerebral inflammation after traumatic brain injury: A revisited concept
Morganti-kossmann Mc, Rancan M, Otto Vi, Stahel Pf, Kossmann T
SHOCK 2001;16(3):165-77

S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury
Pleines Ue, Morganti-kossmann Mc, Rancan M, Joller H, Trentz O, Kossmann T
JOURNAL OF NEUROTRAUMA 2001;18(5):491-8

The duality of the inflammatory response to traumatic brain injury
Lenzlinger Pm, Morganti-kossmann Mc, Laurer Hl, Mcintosh Tk
MOLECULAR NEUROBIOLOGY 2001;24(1-3):169-81

Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats
Rancan M, Otto Vi, Hans Vhj, Gerlach I, Jork R, Trentz O, et al
JOURNAL OF NEUROSCIENCE RESEARCH 2001;63(5):438-46

Cell activation and inflammatory response following traumatic axonal injury in the rat
Csuka E, Hans Vhj, Ammann E, Trentz O, Kossmann T, Morganti-kossmann Mc
NEUROREPORT 2000;11(11):2587-90

Experimental closed head injury: Analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines
Stahel Pf, Shohami E, Younis Fm, Kariya K, Otto Vi, Lenzlinger Pm, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 2000;20(2):369-80

Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice
Stahel Pf, Kariya K, Shohami E, Barnum Sr, Eugster Hp, Trentz O, et al
JOURNAL OF NEUROIMMUNOLOGY 2000;109(2):164-72

sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells
Otto Vi, Heinzel-pleines Ue, Gloor Sm, Trentz O, Kossmann T, Morganti-kossmann Mc
JOURNAL OF NEUROSCIENCE RESEARCH 2000;60(6):733-42

Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta(42) in human CSF - A possible role for nerve cell injury
Emmerling Mr, Morganti-kossmann Mc, Kossmann T, Stahel Pf, Watson Md, Evans Lm, et al
VASCULAR FACTORS IN ALZHEIMER'S DISEASE 2000;:118-22

Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid
Hans Vhj, Kossmann T, Lenzlinger Pm, Probstmeier R, Imhof Hg, Trentz O, et al
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 1999;19(2):184-94

Glutamate and taurine are increased in ventricular cerebrospinal fluid of severely brain-injured patients
Stover Jf, Morganti-kossmann Mc, Lenzlinger Pm, Stocker R, Kempski Os, Kossmann T
JOURNAL OF NEUROTRAUMA 1999;16(2):135-42

IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF-alpha, TGF-beta 1 and blood-brain barrier function
Csuka E, Morganti-kossmann Mc, Lenzlinger Pm, Joller H, Trentz O, Kossmann T
JOURNAL OF NEUROIMMUNOLOGY 1999;101(2):211-21

Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma
Hans Vhj, Kossmann T, Joller H, Otto V, Morganti-kossmann Mc
NEUROREPORT 1999;10(2):409-12

TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function
Morganti-kossmann Mc, Hans Vhj, Lenzlinger Pm, Dubs R, Ludwig E, Trentz O, et al
JOURNAL OF NEUROTRAUMA 1999;16(7):617-28

Thiopental and midazolam do not seem to impede metabolism of glutamate in brain-injured patients
Stover Jf, Pleines Ue, Morganti-kossmann Mc, Stocker R, Kempski Os, Kossmann T
PSYCHOPHARMACOLOGY 1999;141(1):66-70

Thiopental attenuates energetic impairment but fails to normalize cerebrospinal fluid glutamate in brain-injured patients
Stover Jf, Pleines Ue, Morganti-kossmann Mc, Stocker R, Kossmann T
CRITICAL CARE MEDICINE 1999;27(7):1351-7

Increased interleukin-12 levels in human cerebrospinal fluid following severe head trauma
Stahel Pf, Kossmann T, Joller H, Trentz O, Morganti-kossmann Mc
NEUROSCIENCE LETTERS 1998;249(2-3):123-6

Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury
Pleines Ue, Stover Jf, Kossmann T, Trentz O, Morganti-kossmann Mc
JOURNAL OF NEUROTRAUMA 1998;15(6):399-409

The role of the complement system in traumatic brain injury
Stahel Pf, Morganti-kossmann Mc, Kossmann T
BRAIN RESEARCH REVIEWS 1998;27(3):243-56

Thiopental in CSF and serum correlates with prolonged loss of cortical activity
Stover Jf, Lenzlinger Pm, Stocker R, Morganti-kossmann Mc, Imhof Hg, Trentz O, et al
EUROPEAN NEUROLOGY 1998;39(4):223-8

Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid
Raby Ca, Morganti-kossmann Mc, Kossmann T, Stahel Pf, Watson Md, Evans Lm, et al
JOURNAL OF NEUROCHEMISTRY 1998;71(6):2505-9

Neurotransmitters in cerebrospinal fluid reflect pathological activity
Stover Jf, Pleines Ue, Morganti-kossmann Mc, Kossmann T, Lowitzsch K, Kempski Os
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 1997;27(12):1038-43

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