Claudia Kutter
Principal Researcher
E-mail: claudia.kutter@ki.se
Telephone: +46852482819
Visiting address: Tomtebodavägen 23A (Gamma4), 17165 Solna
Postal address: C1 Mikrobiologi, tumör- och cellbiologi, C1 SciLife Kutter, 171 77 Stockholm
About me
- I received my PhD from the University of Basel, Switzerland. During my PhD, I worked on small RNA-mediated regulation of stem cell differentiation at the Friedrich Miescher Institute (Basel, Switzerland). As a postdoctoral researcher, I jointed Cancer Research UK and the University of Cambridge (Cambridge, UK) to study the evolution of noncoding RNAs using next-generation sequencing (NGS) methods. In 2016, I became a SciLifeLab and Wallenberg fellow at the Karolinska Institute (Department of Microbiology, Tumor and Cell Biology). I am leading my independent research group at the Science for Life Laboratory (SciLifeLab) in Stockholm (Sweden).
Research
- *Deciphering genome functionality*
Cells do not exist in one form and adapt quickly, especially in response to metabolic changes. My group studies how this reversible cell phenotype is
controlled by a sophisticated entwined interaction between RNA (long noncoding, transfer and small RNAs) and RNA-binding proteins with a particular focus on liver diseases (from fatty liver to liver cancer).
We have developed and used experimental and computational multi-omics approaches (bulk and single cell genomics, transcriptomics, CRISPR technology combined with cell-based assays) to understand the differences between healthy, reversible and diseased liver cell phenotypes.
Our long term goal is to integrate RNA and their regulators in biomedical research not only for diagnosis and prognosis but also for therapeutic purposes.
*Conference organiser*
* EMBO workshop "RNA: Structure meets Function" [1]
* Transposon symposium [2]
* EpiChrom [3]
* SciLifeLab seminar series [4]
* Science & - SciLifeLab prize [5]
[1] http://meetings.embo.org/event/18-rna
[2] https://transposonsymposium.wordpress.com/
[3] https://www.scilifelab.se/wp-content/uploads/2017/07/epichrom-2017-proceedings.pdf
[4] https://www.scilifelab.se/research/seminars-and-symposia/
[5] http://scienceprize.scilifelab.se/
Teaching
- *BSc/MSc course*
* Methods and Concepts in Molecular Life Sciences [1]
*MSc courses*
* Genomics for Biomedical scientist: Handle your gene expression data [2]
* Molecular Techniques in Life Science [3]
* Bioinformatics [4]
* Frontiers in Translational Medicine [5]
*PhD courses*
* Genomics for Biomedical scientist: Handle your gene expression data [6]
* Non-coding RNAs, microRNAs and their role in human diseases [7]
* The future of medicine: the role of "chance" in development, evolutionary
adaptation and diseases [8]
* Mechanisms of gene regulation in metabolism [9]
* Molecular immunology: noncoding RNAs [10]
* The epigenome: a platform for the integration of metabolic and signaling
pathways in development and on the path to diseases [11]
* Epigenetics and its applications in clinical research [12]
[1] https://www.su.se/english/search-courses-and-programmes/bl4015-1.413043?open-collapse-boxes=
[2] https://kiwas.ki.se/katalog/katalog/kurs/2961
[3] https://education.ki.se/programme/5mt15-masters-programme-in-molecular-techniques-in-life-science
[4] https://education.ki.se/course-syllabus/4BI109/25123
[5] https://education.ki.se/student/frontiers-in-translational-medicine-165-credits/5mt006
[6] https://kiwas.ki.se/katalog/katalog/kurs/2961
[7] http://kiwas.ki.se/katalog/katalog/kurs/2606 - jsessionid=8160a6c4f65b50094b841c2e8d8a
[8] http://kiwas.ki.se/katalog/katalog/kurs/2608
[9] http://kiwas.ki.se/katalog/katalog/kurs/2879 - jsessionid=f7fe4341aab8f72b18b92c083877
[10] http://kiwas.ki.se/katalog/katalog/kurs/2855 - jsessionid=a7194e4337ddf02f679f82c24fc1
[11] http://kiwas.ki.se/katalog/katalog/kurs/2414 - jsessionid=a508b4a11f840c784347074883e5
[12] https://kise-my.sharepoint.com/Users/claudiakutter/Dropbox/KI_SciLifeLab/WebPage_KI/Epigenetics and its applications in clinical research
Articles
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Article: MOLECULAR SYSTEMS BIOLOGY. 2024;20(4):374-402
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Article: LIFE SCIENCE ALLIANCE. 2024;7(2):e202302128
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Article: SCIENCE ADVANCES. 2023;9(41):eadg5109
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Article: SCIENCE ADVANCES. 2023;9(34):eadg1610
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Article: COMMUNICATIONS BIOLOGY. 2022;5(1):1057
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Article: GENOME RESEARCH. 2022;32(10):1876-1891
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Article: EMBO REPORTS. 2022;23(7):e54499
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(11):5990
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Article: EMBO REPORTS. 2022;23(3):e53191
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Article: GUT. 2022;71(10):gutjnl-2021-325109-2092
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Article: FRONTIERS IN IMMUNOLOGY. 2022;13:854312
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Article: GENOME RESEARCH. 2022;32(1):97-110
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Article: METHODS IN MOLECULAR BIOLOGY. 2022;2418:313-343
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Article: RNA BIOLOGY. 2021;18(11):1588-1599
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Article: GENOME BIOLOGY AND EVOLUTION. 2021;13(4):evab016
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Article: COMMUNICATIONS BIOLOGY. 2021;4(1):14
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Article: SCIENCE ADVANCES. 2021;7(1):eabe4724
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Article: ONCOTARGETS AND THERAPY. 2021;14:1753-1769
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Article: COMMUNICATIONS BIOLOGY. 2020;3(1):319
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Article: SCIENTIFIC REPORTS. 2020;10(1):3637
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Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:554922
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Article: NATURE METABOLISM. 2019;1(4):445-459
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Article: ELIFE. 2016;5:e20235
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Article: PLOS GENETICS. 2016;12(5):e1006024
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Article: GENOME RESEARCH. 2014;24(11):1797-1807
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Article: ELIFE. 2014;3:e02626
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Article: EMBO JOURNAL. 2014;33(18):2020-2039
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Article: ELIFE. 2013;2:e00348
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Article: MOLECULAR CELL. 2013;49(2):262-272
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Article: PLOS ONE. 2013;8(3):e59459
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Article: SCIENCE. 2012;338(6114):1587-1593
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Article: PLANT PHYSIOLOGY. 2012;158(4):1715-1727
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Journal article: CELL. 2012;148(4):832
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Article: CELL. 2012;148(1-2):335-348
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Article: PLOS ONE. 2012;7(8):e41762
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Article: PLOS GENETICS. 2012;8(7):e1002841
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Article: PLANT PHYSIOLOGY. 2011;157(2):683-691
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Article: NATURE GENETICS. 2011;43(10):948-955
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Article: SCIENCE. 2010;328(5981):1036-1040
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Journal article: NEW BIOTECHNOLOGY. 2010;27:s34
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Journal article: NEW BIOTECHNOLOGY. 2010;27:s4
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Article: RNA BIOLOGY. 2008;5(4):181-188
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Journal article: PLANT CELL. 2007;19(11):3831
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Article: PLANT CELL. 2007;19(8):2417-2429
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Article: JOURNAL OF PLANT PHYSIOLOGY. 2006;163(3):297-306
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Article: NUCLEIC ACIDS RESEARCH. 2006;34(2):462-471
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Article: PLANT AND CELL PHYSIOLOGY. 2003;44(6):643-648
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All other publications
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Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S122
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Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;323(4):C1003-C1017
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Preprint: BIORXIV. 2021
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Corrigendum: NATURE METABOLISM. 2021;3(2):287
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Preprint: BIORXIV. 2021
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Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(9):S292
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Corrigendum: NATURE METABOLISM. 2019;1(4):497
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Editorial comment: MOBILE DNA. 2018;9:34
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Conference publication: HEPATOLOGY. 2018;68:824A
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Review: NATURE COMMUNICATIONS. 2017;8(1):1411
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Conference publication: HEPATOLOGY. 2009;50(4):1092A
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Published conference paper: ENGINEERING IN LIFE SCIENCES. 2004;4(1):61-65
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Grants
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Swedish Research Council1 January 2024 - 31 December 2027
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Swedish Research Council1 January 2020 - 31 December 2023
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Swedish Research Council1 November 2018 - 30 November 2018
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Swiss National Science Foundation1 July 2008 - 31 July 2010