Cecilia Österholm Corbascio

Publications
CV
Public outreach and news

Articles

Article: FRONTIERS IN ONCOLOGY. 2023;13:1097942

T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations.

Vlachonikola E; Pechlivanis N; Karakatsoulis G; Sofou E; Gkoliou G; Jeromin S; Stavroyianni N; Ranghetti P; Scarfo L; Österholm C; Mansouri L; Notopoulou S; Siorenta A; Anagnostopoulos A; Ghia P; Haferlach C; Rosenquist R; Psomopoulos F; Kouvatsi A; Baliakas P; Stamatopoulos K; Chatzidimitriou A
Article: NATURE COMMUNICATIONS. 2022;13(1):6226

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.

Herbst SA; Vesterlund M; Helmboldt AJ; Jafari R; Siavelis I; Stahl M; Schitter EC; Liebers N; Brinkmann BJ; Czernilofsky F; Roider T; Bruch P-M; Iskar M; Kittai A; Huang Y; Lu J; Richter S; Mermelekas G; Umer HM; Knoll M; Kolb C; Lenze A; Cao X; Österholm C; Wahnschaffe L; Herling C; Scheinost S; Ganzinger M; Mansouri L; Kriegsmann K; Kriegsmann M; Anders S; Zapatka M; Del Poeta G; Zucchetto A; Bomben R; Gattei V; Dreger P; Woyach J; Herling M; Müller-Tidow C; Rosenquist R; Stilgenbauer S; Zenz T; Huber W; Tausch E; Lehtiö J; Dietrich S
Article: METABOLISM OPEN. 2022;13:100167

Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells.

Olesen K; Moruzzi N; Bulatovic I; Folmes C; Jeon R; Felldin U; Terzic A; Simonson OE; Le Blanc K; Österholm C; Berggren P-O; Schiffer T; Rodin S; Tilevik A; Grinnemo K-H
Article: STEM CELLS. 2021;39(12):1751-1765

Spatiotemporal extracellular matrix modeling for in situ cell niche studies.

Olesen K; Rodin S; Mak WC; Felldin U; Österholm C; Tilevik A; Grinnemo K-H
Article: BIORESEARCH OPEN ACCESS. 2020;9(1):269-278

Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold.

Granath C; Noren H; Björck H; Simon N; Olesen K; Rodin S; Grinnemo K-H; Österholm C
Article: JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY. 2020;159(6):2525-2537.e23

Synthetic tracheal grafts seeded with bone marrow cells fail to generate functional tracheae: First long-term follow-up study.

Fux T; Österholm C; Themudo R; Simonson O; Grinnemo K-H; Corbascio M
Article: CELL. 2019;179(7):1647-1660.e19

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart.

Asp M; Giacomello S; Larsson L; Wu C; Fürth D; Qian X; Wärdell E; Custodio J; Reimegård J; Salmén F; Österholm C; Ståhl PL; Sundström E; Åkesson E; Bergmann O; Bienko M; Månsson-Broberg A; Nilsson M; Sylvén C; Lundeberg J
Article: STEM CELL RESEARCH & THERAPY. 2019;10(1):371

Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells.

Grinnemo K-H; Löfling M; Nathanson L; Baumgartner R; Ketelhuth DFJ; Beljanski V; Davies LC; Österholm C
Article: ATHEROSCLEROSIS. 2019;283:127-136

Dual roles of heparanase in human carotid plaque calcification.

Aldi S; Eriksson L; Kronqvist M; Lengquist M; Löfling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Österholm C; Hedin U
Article: STEM CELLS AND DEVELOPMENT. 2019;28(5):310-318

Human Fetal Cardiac Mesenchymal Stromal Cells Differentiate In Vivo into Endothelial Cells and Contribute to Vasculogenesis in Immunocompetent Mice.

Ljung K; Grönlund A; Felldin U; Rodin S; Corbascio M; Österholm C; Grinnemo K-H
Article: SCIENTIFIC REPORTS. 2018;8(1):2777

Altered DNA methylation indicates an oscillatory flow mediated epithelial-to-mesenchymal transition signature in ascending aorta of patients with bicuspid aortic valve.

Björck HM; Du L; Pulignani S; Paloschi V; Lundströmer K; Kostina AS; Österholm C; Malashicheva A; Kostareva A; Evangelista A; Teixidó-Tura G; Maleki S; Franco-Cereceda A; Eriksson P; Mechanistic Interrogation of Bicuspid Aortic Valve
Article: CIRCULATION RESEARCH. 2017;120(4):633-644

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions.

Eken SM; Jin H; Chernogubova E; Li Y; Simon N; Sun C; Korzunowicz G; Busch A; Bäcklund A; Österholm C; Razuvaev A; Renné T; Eckstein HH; Pelisek J; Eriksson P; González Díez M; Perisic Matic L; Schellinger IN; Raaz U; Leeper NJ; Hansson GK; Paulsson-Berne G; Hedin U; Maegdefessel L
Article: DIABETES. 2016;65(10):2888-2899

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness.

Strawbridge RJ; Hilding A; Silveira A; Österholm C; Sennblad B; McLeod O; Tsikrika P; Foroogh F; Tremoli E; Baldassarre D; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Mannarino E; Grossi E; Syvänen A-C; Humphries SE; de Faire U; Östenson C-G; Maegdefessel L; Hamsten A; Bäcklund A; IMPROVE Study Group
Article: ONCOTARGET. 2016;7(26):39486-39496

Heparanase expression upregulates platelet adhesion activity and thrombogenicity.

Cui H; Tan Y-X; Österholm C; Zhang X; Hedin U; Vlodavsky I; Li J-P
Article: STEM CELL REPORTS. 2016;6(4):607-617

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells.

Månsson-Broberg A; Rodin S; Bulatovic I; Ibarra C; Löfling M; Genead R; Wärdell E; Felldin U; Granath C; Alici E; Le Blanc K; Smith CIE; Salašová A; Westgren M; Sundström E; Uhlén P; Arenas E; Sylvén C; Tryggvason K; Corbascio M; Simonson OE; Österholm C; Grinnemo K-H
Article: PLOS ONE. 2015;10(3):e0120176

Sublethal caspase activation promotes generation of cardiomyocytes from embryonic stem cells.

Bulatovic I; Ibarra C; Österholm C; Wang H; Beltrán-Rodríguez A; Varas-Godoy M; Månsson-Broberg A; Uhlén P; Simon A; Grinnemo K-H
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2014;3(12):1484-1494

Multipotent mesenchymal stromal cells synergize with costimulation blockade in the inhibition of immune responses and the induction of Foxp3+ regulatory T cells.

Takahashi T; Tibell A; Ljung K; Saito Y; Gronlund A; Osterholm C; Holgersson J; Lundgren T; Ericzon B-G; Corbascio M; Kumagai-Braesch M
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(10):2432-2443

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.

Perisic L; Hedin E; Razuvaev A; Lengquist M; Osterholm C; Folkersen L; Gillgren P; Paulsson-Berne G; Ponten F; Odeberg J; Hedin U
Article: ATHEROSCLEROSIS. 2013;226(1):67-73

Increased expression of heparanase in symptomatic carotid atherosclerosis.

Osterholm C; Folkersen L; Lengquist M; Pontén F; Renné T; Li J; Hedin U
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;302(11):L1159-L1166

Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia.

Chang Y-T; Ringman Uggla A; Osterholm C; Tran P-K; Eklöf A-C; Lengquist M; Hedin U; Tran-Lundmark K; Frenckner B
Article: PLOS ONE. 2012;7(7):e41334

Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids.

Österholm C; Lu N; Lidén Å; Karlsen TV; Gullberg D; Reed RK; Kusche-Gullberg M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(50):34935-34943

Mutation in the heparan sulfate biosynthesis enzyme EXT1 influences growth factor signaling and fibroblast interactions with the extracellular matrix.

Osterholm C; Barczyk MM; Busse M; Grønning M; Reed RK; Kusche-Gullberg M
Article: CELL AND TISSUE RESEARCH. 2008;334(1):93-102

Downregulation of tissue factor (TF) by RNA interference induces apoptosis and impairs cell survival of primary endothelium and tumor cells.

Osterholm C; Li S; Ekberg H; Hedner U; Holgersson J
Article: TRANSPLANTATION. 2007;83(9):1259-1267

Anti-LFA-1 improves pig islet xenograft function in diabetic mice when long-term acceptance is induced by CTLA4Ig/anti-CD40L.

Kumagai-Braesch M; Ekberg H; Wang F; Osterholm C; Ehrnfelt C; Sharma A; Lindeborg E; Holgersson J; Corbascio M
Article: TRANSPLANT IMMUNOLOGY. 2005;15(2):165-172

Differential expression of tissue factor (TF) in calcineurin inhibitor-induced nephrotoxicity and rejection--implications for development of a possible diagnostic marker.

Osterholm C; Veress B; Simanaitis M; Hedner U; Ekberg H
Article: TRANSPLANTATION. 2002;74(1):35-41

Anti-lymphocyte function-associated antigen-1 monoclonal antibody inhibits CD40 ligand-independent immune responses and prevents chronic vasculopathy in CD40 ligand-deficient mice.

Corbascio M; Mahanty H; Osterholm C; Qi Z; Pearson TC; Larsen CP; Freise CE; Ekberg H
Article: TRANSPLANT IMMUNOLOGY. 2002;10(1):55-61

CTLA4Ig combined with anti-LFA-1 prolongs cardiac allograft survival indefinitely.

Corbascio M; Ekstrand H; Osterholm C; Qi Z; Simanaitis M; Larsen CP; Pearson TC; Riesbeck K; Ekberg H
Article: TRANSPLANTATION. 2002;73(2):293-297

CTLA4ig induces long-term graft survival of allogeneic skin grafts and totally inhibits T-cell proliferation in LFA-1-deficient mice.

Malm H; Corbascio M; Osterholm C; Cowan S; Larsen CP; Pearson TC; Ekberg H
Article: AMERICAN JOURNAL OF TRANSPLANTATION. 2001;1(1):29-37

Initial inhibition of tissue factor signalling reduces chronic vascular changes in isogenic rat aortic transplants.

Osterholm C; Qi Z; Ekberg J; Veress B; Pyke C; Hedner U; Ekberg H
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All other publications

Review: FRONTIERS IN ONCOLOGY. 2023;13:1143811

Recent revelations and future directions using single-cell technologies in chronic lymphocytic leukemia.

Oder B; Chatzidimitriou A; Langerak AW; Rosenquist R; Österholm C
Review: CYTOTHERAPY. 2019;21(4):380-392

Pleiotropic roles of autophagy in stem cell-based therapies.

Beljanski V; Grinnemo K-H; Österholm C

Employments

Senior Research Specialist, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2021

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