My overall aim is to evaluate the clinical potential and significance of stem and progenitor cells obtained from perinatal tissues.
PhD 2004, Karolinska Institutet, Stockholm, Sweden.
Subject: Allogeneic stem cell transplantation & transplantation research.
Thesis: Characterization of human fetal mesenchymal stem cells.
MSc 2001, Södertörns University College, Stockholm, Sweden.
Subject: Molecular Cell Biology.
Degree thesis: Clinical aspects on maternal cells in the fetus.
Cells derived from the fetus and membranes have more potential than cells derived from adult tissues. Promising candidates are multipotent mesenchymal stromal cells (MSC).
The interest in these cells is based on their multipotentiality, immunomodulatory, anti-inflammatory and tissue repairing effects in combination with a minimal oncogeneic risk.
1. Characterizing and comparing MSC from different perinatal sources
We work with many perinatal sources: fetal tissues (first trimester), amniotic fluid, chorionic villus, biopsies of muscle and skin (second trimester), umbilical cord blood, placenta, Wharton´s Jelly (term).
These cells are evaluated for their potential in perinatal regenerative medicine in clinical application as seen below. We also evaluate how maternal and fetal microchimerism, pregnancy, and mode of delivery affect the isolated cells.
2. Developing new clinical treatment options using perinatal MSC for:
Prenatal transplantation for severe osteogenesis imperfecta (clinical treatments ongoing)
Severe structural defects diagnosed before birth
Life threatening bronchopulmonary dysplasia and necrotizing enterocolitis in premature babies
3. Wait a minute - umbilical cord blood collection and clamping
Umbilical cord blood contains large amounts of unique blood stem cells that can be used to cure people with leukemia. However, lately late umbilical cord clamping has been proposed and applied in many hospitals in Sweden since late clamping has been associated with increased iron depots in the child. It is unclear how this relates to health and wellbeing of the infant.
We are examining how clamping at 1 minute affects children's health status related to early (<10 seconds) or late (>3 minutes) clamping. We are also evaluating if it is possible to collect cord blood for clinical banking with clamping at 1 minute.