Professor in cell and tumour biology.
Faculty representative, Board of research, Karolinska Institute.
As faculty representative I consider that one of my central missions is to work towards the development distinct and transparent processes for recruitment, career development and distribution of faculty funds. All with the overall aim to promote high quality research at Karolinska Institutet.
1997 PhD in Natural Sciences, Department of Cell Biology, Wenner-Gren Institute, Stockholm University, Sweden
1990 Master degree in Natural Sciences, Department of Cell Biology, Wenner-Gren Institute, Stockholm University, Sweden
The molecular mechanisms which maintain genome stability are essential for life and prevent accumulation of disease-promoting chromosomal aberrations. With the aim to decipher these mechanisms, our project focuses on the evolutionary conserved family of SMC protein complexes (SMC: Structural Maintenance of Chromosomes).
There are three eukaryotic complexes: cohesin, condensin and the Smc5/6 complex. The majority of our ongoing investigations aim to disclose the function of the Smc5/6 complex, which is the least well understood. We do this using the budding yeast Saccharomyces cerevisiae as model organism.
The Smc5/6 complex has mainly been functionally connected with DNA repair and we have found that it is recruited to DNA breaks where it activates cohesin. We have also shown that Smc5/6 binds to chromosomes as a consequence of DNA replication. Intriguingly, the frequency of Smc5/6 binding sites increases in linear correlation with the length of chromosomes, and we have unraveled a function for Smc5/6 in the resolution of replication-induced topological tension. This tension arises when the replication machinery pries apart the parental double-helix into single DNA strands. If the tension is not removed, it will lead to replication fork blockage which increases the risk of genomic rearrangements. Our more recent results suggest that topological tension also could have a positive role in the organization of chromosomes, executed via the SMC complexes.
Academic honours, awards and prizes
2014 Nicholson lecturer at Rockefeller University, NY, USA
2008 European Research Council (ERC) Starting Grant
2008 Fernströms prize to young researchers
2007 Royal Swedish Academy of Sciences Research Fellow in Medical sciences
2002 Junior research position grant, Swedish Research Council
1998 Postdoctoral fellowship by The Swedish Foundation for International Cooperation in Research and Higher Education (STINT)
The SMC complexes, DNA and chromosome topology: right or knot?
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY 2012;47(1):1-16
Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival
JOURNAL OF CELL SCIENCE 2011;124(16):2735-42
Chromosome length influences replication-induced topological stress
S-phase and DNA damage activated establishment of Sister chromatid cohesion-importance for DNA repair
EXPERIMENTAL CELL RESEARCH 2010;316(9):1445-53
The SMC5/6 complex and replication-induced topological stress
FEBS JOURNAL 2010;:30-30
The Smc5/6 complex: more than repair?
Cold Spring Harbor symposia on quantitative biology 2010;75():179-87
Chromosome segregation and double-strand break repair - a complex connection
CURRENT OPINION IN CELL BIOLOGY 2007;19(3):344-9
DNA damage-induced sister chromatid cohesion
FASEB JOURNAL 2007;21(5):A95-A95
Postreplicative formation of cohesion is required for repair and induced by a single DNA break
Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways
MOLECULAR CELL 2006;22(6):755-67
DNA damage-induced cohesion
CELL CYCLE 2005;4(4):536-9
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair
MOLECULAR CELL 2004;16(6):1003-15
Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae
CURRENT BIOLOGY 2001;11(12):991-5
The role of profilin in actin polymerization and nucleotide exchange
Characterization of a mutant profilin with reduced actin-binding capacity: effects in vitro and in vivo
Experimental cell research 1997;234(1):66-77
Isolation and characterization of two mutants of human profilin I that do not bind poly(L-proline)
FEBS letters 1997;418(3):258-64
2012-present Faculty representative at the Karolinska Institutet’s Board of Research
2005-present Vice chairman, Dept. of Cell and Molecular Biology, Karolinska Insitutet
2008-2011 Board member, Swedish society for Biochemistry and Molecular Biology (SFBBM)
Commissions of trust
2009-2014 Member of Swedish Cancer Foundation project grant evaluation panel, panel vice chair 2011-2012, chair 2013-2014.
2009-2012 Member of starting grant evaluation panel, European Research Council, panel vice chair 2011-2012.
2008 Member of evaluation panel, Swedish Research Council. Project grant applications.
2002-present Evaluator of candidates for EMBO fellowships, two professorships at University of Copenhagen, and two Wellcome Trust grant applications. Guest Editor for Experimental Cell Research, special issue on DNA repair, Reviewer of manuscripts submitted to Science, EMBO reports, EMBO Journal, Molecular Cell, Current Biology, Genes and Development, Nucleic Acid Research, Journal of Clinical Investigation, and more