Denna sida på svenska

Burcu Bestas


Visiting address : Molekylär Cell Genetik och Genterapiforskning (MCG); Novum plan 5, Hiss F, Lab 514; Hälsovägen 7-9, 141 57 Huddinge, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Clinical research center, Molekylär Cell Genetik och Genterapiforskning (MCG); Novum plan 5, Hiss F, Lab 514; Hälsovägen 7-9, 141 57 Huddinge, Sweden
Delivery address : KFC/MCG Lab 514 Novum pl 5; Karolinska Universitetssjukhuset Huddinge, 141 52 Huddinge, Sweden

Research description

Research area/interest: Non-viral vectors for gene therapy, nuclear targeting mechanisms, nucleic acids as tools for antigene, antisense and splice modifications.


Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency
Sork H, Nordin Jz, Turunen Jj, Wiklander Op, Bestas B, Zaghloul Em, et al
Molecular therapy. Nucleic acids 2016;5():e290-

Synthetic m(3)G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal
Honcharenko M, Bestas B, Jezowska M, Wojtczak Ba, Moreno Pmd, Romanowska J, et al
RSC ADVANCES 2016;6(56):51367-51373

Splice-correction strategies for treatment of X-linked agammaglobulinemia
Bestas B, Turunen Jj, Blomberg Ke, Wang Q, Månsson R, El Andaloussi S, et al
Current allergy and asthma reports 2015;15(3):510-

Design and application of bispecific splice-switching oligonucleotides
Bestas B, Mcclorey G, Tedebark U, Moreno Pm, Roberts Tc, Hammond Sm, et al
Nucleic acid therapeutics 2014;24(1):13-24

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Bestas B, Moreno Pmd, Blomberg Kem, Mohammad Dk, Saleh Af, Sutlu T, et al

Agammaglobulinemia: causative mutations and their implications for novel therapies
Berglöf A, Turunen Jj, Gissberg O, Bestas B, Blomberg Ke, Smith Ci
Expert review of clinical immunology 2013;9(12):1205-21

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
Moreno Pm, Geny S, Pabon Yv, Bergquist H, Zaghloul Em, Rocha Cs, et al
Nucleic acids research 2013;41(5):3257-73

Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract
Honcharenko M, Zytek M, Bestas B, Moreno P, Jemielity J, Darzynkiewicz E, et al
Bioorganic & medicinal chemistry 2013;21(24):7921-8

Synthesis of biotin linkers with the activated triple bond donor [p-(N-propynoylamino)toluic acid] (PATA) for efficient biotinylation of peptides and oligonucleotides
Jezowska M, Romanowska J, Bestas B, Tedebark U, Honcharenko M
Molecules (Basel, Switzerland) 2012;17(12):14174-85

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA
Zaghloul Em, Madsen As, Moreno Pm, Oprea Ii, El-andaloussi S, Bestas B, et al
Nucleic acids research 2011;39(3):1142-54