Denna sida på svenska

Anna Karlsson

Professor/specialist physician

Visiting address : Alfred Nobels Allé 8, Plan 7, Karolinska Universitetssjukhuset, Huddinge 141 86 Stockholm, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Division of Clinical Microbiology, F68, Karolinska Universitetssjukhuset, Huddinge 141 86 Stockholm, Sweden
Delivery address : F68, Karolinska Universitetssjukhuset, Huddinge 141 86 Stockholm, Sweden

Publications

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition
Reiser K, Mathys L, Curbo S, Pannecouque C, Noppen S, Liekens S, et al
PloS one 2016;11(1):e0147773-

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells
Bartesaghi S, Graziano V, Galavotti S, Henriquez Nv, Betts J, Saxena J, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(4):1059-64

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells (vol 112, pg 1059, 2015)
Bartesaghi S, Graziano V, Galavotti S, Henriquez Nv, Betts J, Saxena J, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015;112(11):E1401-

Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria
Jiang H, Zhao L, Dong X, He A, Zheng C, Johansson M, et al
Oncology reports 2015;34(3):1487-93

The mitochondrial carrier SLC25A10 regulates cancer cell growth
Zhou X, Paredes Ja, Krishnan S, Curbo S, Karlsson A
Oncotarget 2015;6(11):9271-83

Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances
Krishnan S, Paredes Ja, Zhou X, Kuiper Rv, Hultenby K, Curbo S, et al
The Journal of biological chemistry 2014;289(47):32835-44

The many isoforms of human adenylate kinases
Panayiotou C, Solaroli N, Karlsson A
The international journal of biochemistry & cell biology 2014;49():75-83

Gene expression deregulation in postnatal skeletal muscle of TK2 deficient mice reveals a lower pool of proliferating myogenic progenitor cells
Paredes Ja, Zhou X, Höglund S, Karlsson A
PloS one 2013;8(1):e53698-

Is trichloroacetic acid an insufficient sample quencher of redox reactions?
Curbo S, Reiser K, Rundlöf Ak, Karlsson A, Lundberg M
Antioxidants & redox signaling 2013;18(7):795-9

Late-onset respiratory failure due to TK2 mutations causing multiple mtDNA deletions
Alston Cl, Schaefer Am, Raman P, Solaroli N, Krishnan Kj, Blakely El, et al
Neurology 2013;81(23):2051-3

Potent antitumoral effects of targeted promoter-driven oncolytic adenovirus armed with Dm-dNK for breast cancer in vitro and in vivo
Dong Xs, Qu Wz, Ma S, Zhu Z, Zheng Cw, He An, et al
CANCER LETTERS 2013;328(1):95-103

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase
Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N
The international journal of biochemistry & cell biology 2013;45(5):925-31

Thymidine kinase 2 deficiency-induced mtDNA depletion in mouse liver leads to defect β-oxidation
Zhou X, Kannisto K, Curbo S, Von Döbeln U, Hultenby K, Isetun S, et al
PloS one 2013;8(3):e58843-

Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency
Krishnan S, Zhou X, Paredes Ja, Kuiper Rv, Curbo S, Karlsson A
The Journal of biological chemistry 2013;288(7):5072-9

Introduction of a Fluorine Atom at C3 of 3-Deazauridine Shifts Its Antimetabolic Activity from Inhibition of CTP Synthetase to Inhibition of Orotidylate Decarboxylase, an Early Event in the de Novo Pyrimidine Nucleotide Biosynthesis Pathway
Balzarini J, Gago F, Kulik W, Van Kuilenburg Abp, Karlsson A, Peterson Ma, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(36):30444-54

Recent Advances in Thymidine Kinase 2 (TK2) Inhibitors and New Perspectives for Potential Applications
Priego Em, Karlsson A, Gago F, Camarasa Mj, Balzarini J, Perez-perez Mj
CURRENT PHARMACEUTICAL DESIGN 2012;18(20):2981-94

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120
Reiser K, Francois Ko, Schols D, Bergman T, Jornvall H, Balzarini J, et al
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2012;44(3):556-62

Design, synthesis and biological evaluation of 2 '-deoxy-2 ',2 '-difluoro-5-halouridine phosphoramidate ProTides
Quintiliani M, Persoons L, Solaroli N, Karlsson A, Andrei G, Snoeck R, et al
BIOORGANIC & MEDICINAL CHEMISTRY 2011;19(14):4338-45

Identification of genes associated to 2 ',2 '-difluorodeoxycytidine resistance in HeLa cells with a lentiviral short-hairpin RNA library
Xu Yj, Karlsson A, Johansson M
BIOCHEMICAL PHARMACOLOGY 2011;82(3):210-5

Synthesis, modeling and evaluation of 3 '-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3 '-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Van Poecke S, Negri A, Janssens J, Solaroli N, Karlsson A, Gago F, et al
ORGANIC & BIOMOLECULAR CHEMISTRY 2011;9(3):892-901

The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes
Panayiotou C, Solaroli N, Xu Yj, Johansson M, Karlsson A
BIOCHEMICAL JOURNAL 2011;:527-34

The multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster as a therapeutic suicide gene of breast cancer cells
Ma Sa, Zhao L, Zhu Z, Liu Q, Xu Hm, Johansson M, et al
JOURNAL OF GENE MEDICINE 2011;13(6):305-11

3 '-[4-Aryl-(1,2,3-triazol-1-yl)]-3 '-deoxythymidine Analogues as Potent and Selective Inhibitors of Human Mitochondrial Thymidine Kinase
Van Poecke S, Negri A, Gago F, Van Daele I, Solaroli N, Karlsson A, et al
JOURNAL OF MEDICINAL CHEMISTRY 2010;53(7):2902-12

Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4
Panayiotou C, Solaroli N, Johansson M, Karlsson A
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 2010;42(1):62-9

Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome
Zhou Xs, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A
JOURNAL OF INHERITED METABOLIC DISEASE 2010;33(3):231-6

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration
Bartesaghi S, Betts-henderson J, Cain K, Dinsdale D, Zhou Xs, Karlsson A, et al
HUMAN MOLECULAR GENETICS 2010;19(9):1669-77

RETAINED SENSITIVITY TO CYTOTOXIC PYRIMIDINE NUCLEOSIDE ANALOGS IN THYMIDINE KINASE 2 DEFICIENT HUMAN FIBROBLASTS
Bjerke M, Solaroli N, Lesko N, Balzarini J, Johansson M, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2010;29(1):1-13

Retrovirus-mediated Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase Gene Therapy of Gastric Cancer Cells In Vitro and In Vivo
Zhu Z, Zhao L, He An, Huang Bj, Karlsson A, Xu Hm, et al
ANTICANCER RESEARCH 2010;30(7):2641-9

Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion
Lesko N, Naess K, Wibom R, Solaroli N, Nennesmo I, Von Dobeln U, et al
NEUROMUSCULAR DISORDERS 2010;20(3):198-203

Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA
Curbo S, Johansson M, Balzarini J, Lewis Ld, Karlsson A
EXPERIMENTAL CELL RESEARCH 2009;315(15):2539-43

Human Mitochondrial Thymidine Kinase Is Selectively Inhibited by 3 '-Thiourea Derivatives of beta-Thymidine: Identification of Residues Crucial for Both Inhibition and Catalytic Activity
Balzarini J, Van Daele I, Negri A, Solaroli N, Karlsson A, Liekens S, et al
MOLECULAR PHARMACOLOGY 2009;75(5):1127-36

Identification of two active functional domains of human adenylate kinase 5
Solaroli N, Panayiotou C, Johansson M, Karlsson A
FEBS LETTERS 2009;583(17):2872-6

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides
Curbo S, Gaudin R, Carlsten M, Malmberg Kj, Troye-blomberg M, Ahlborg N, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009;390(4):1272-7

Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria
Xu Yj, Johansson M, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 2008;283(3):1563-71

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
Zhou Xs, Solaroli N, Bjerke M, Stewart Jb, Rozell B, Johansson M, et al
HUMAN MOLECULAR GENETICS 2008;17(15):2329-35

Reduced levels of mitochondrial DNA increases the toxicity of 9-beta-D-arabinofuranosylguanine (araG)
Bjerke M, Balzarini J, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2008;27(6-7):746-9

Substrate specificity of feline and canine herpesvirus thymidine kinase
Solaroli N, Johansson M, Persoons L, Balzarini J, Karlsson A
ANTIVIRAL RESEARCH 2008;79(2):128-32

Two novel mutations in thymidine kinase-2 leading to an early onset fatal encephalomyopathy and severe DNA depletion
Naess K, Lesko N, Wibom R, Nennesmo I, Solaroli N, Von Dobeln U, et al
JOURNAL OF INHERITED METABOLIC DISEASE 2008;:59-59

Depletion of mitochondrial DNA by down-regulation of deoxyguanosine kinase expression in non-proliferating HeLa cells
Franco M, Johansson M, Karlsson A
EXPERIMENTAL CELL RESEARCH 2007;313(12):2687-94

Enhanced toxicity of purine nucleoside analogs in cells expressing Drosophila melanogaster nucleoside kinase mutants
Solaroli N, Johansson M, Balzarini J, Karlsson A
GENE THERAPY 2007;14(1):86-92

Mitochondrial expression of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Solaroli N, Zheng Xy, Johansson M, Balzarini J, Karlsson A
MOLECULAR PHARMACOLOGY 2007;72(6):1593-8

Novel selective human mitochondrial kinase inhibitors: Design, synthesis and enzymatic activity
Ciliberti N, Manfredini S, Angusti A, Durini E, Solaroli N, Vertuani S, et al
BIOORGANIC & MEDICINAL CHEMISTRY 2007;15(8):3065-81

Alterations of mitochondrial DNA in CEM cells selected for resistance toward ddC toxicity
Bjerke M, Franco M, Johansson M, Balzarini J, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2006;25(9-11):987-90

Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation
Balzarini J, Liekens S, Solaroli N, El Omari K, Stammers Dk, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(28):19273-9

Human mitochondrial pyrophosphatase: cDNA cloning and analysis of the gene in patients with mtDNA depletion syndromes
Curbo S, Lagier-tourenne C, Carrozzo R, Palenzuela L, Lucioli S, Hirano M, et al
GENOMICS 2006;87(3):410-6

N-1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors
Hernandez Ai, Familiar O, Negri A, Rodriguez-barrios F, Gago F, Karlsson A, et al
JOURNAL OF MEDICINAL CHEMISTRY 2006;49(26):7766-73

Nelarabine: a new purine analog in the treatment of hematologic malignancies
Curbo S, Karlsson A
Reviews on recent clinical trials 2006;1(3):185-92

New ultrasensitive P-32-postlabelling method for the analysis of 3,N-4-etheno-2 '-deoxycytidine in human urine
Sun X, Karlsson A, Bartsch H, Nair J
BIOMARKERS 2006;11(4):329-40

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
El Omari K, Solaroli N, Karlsson A, Balzarini J, Stammers Dk
BMC STRUCTURAL BIOLOGY 2006;:22-

Substrate specificity of three viral thymidine kinases (TK): Vaccinia virus TK, feline herpesvirus TK, and canine herpesvirus TK
Solaroli N, Johansson M, Balzarini J, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2006;25(9-11):1189-92

Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster
Bertoli A, Franco M, Balzarini J, Johansson M, Karlsson A
FEBS JOURNAL 2005;272(15):3918-28

Phosphorylation of 9-beta-D-arabinofuranosylguanine monophosphate by Drosophila melanogaster guanylate kinase
Johansson M, Amiri M, Karlsson A
BIOCHEMICAL PHARMACOLOGY 2005;70(7):987-92

5-Fluoro-2 '-deoxyuridine has effects on mitochondria in CEM T-lymphoblast cells
Curbo S, Johansson M, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2004;23(8-9):1495-8

Investigation of the substrate recognition of Drosophila melanogaster nucleoside kinase by site directed mutagenesis
Solaroli N, Bjerke M, Johansson M, Karlsson A
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 2004;23(8-9):1527-9

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes
Priego Em, Balzarini J, Karlsson A, Camarasa Mj, Perez-perez Mj
BIOORGANIC & MEDICINAL CHEMISTRY 2004;12(19):5079-90

The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT
Auwerx J, Stevens M, Van Rompay Ar, Bird Le, Ren Js, De Clerq E, et al
JOURNAL OF VIROLOGY 2004;78(14):7427-37

Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Solaroli N, Bjerke M, Amiri Mh, Johansson M, Karlsson A
EUROPEAN JOURNAL OF BIOCHEMISTRY 2003;270(13):2879-84

Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy
Mazzon C, Rampazzo C, Scaini Mc, Gallinaro L, Karlsson A, Meier C, et al
BIOCHEMICAL PHARMACOLOGY 2003;66(3):471-9

Effects of 9-beta-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells
Curbo S, Zhivotovsky B, Johansson M, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;307(4):942-7

Improving the selectivity of acyclic nucleoside analogues as inhibitors of human mitochondrial thymidine kinase: Replacement of a triphenylmethoxy moiety with substituted amines and carboxamides
Hernandez Ai, Balzarini J, Rodriguez-barrios F, San-felix A, Karlsson A, Gago F, et al
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2003;13(18):3027-30

Lipid-mediated protein delivery of suicide nucleoside kinases
Zheng Xy, Lundberg M, Karlsson A, Johansson M
CANCER RESEARCH 2003;63(20):6909-13

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase
Balzarini J, Hernandez Ai, Roche P, Esnouf R, Karlsson A, Camarasa Mj, et al
MOLECULAR PHARMACOLOGY 2003;63(2):263-70

Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: Studies of the Drosophila deoxyribonucleoside kinase
Mikkelsen Ne, Johansson K, Karlsson A, Knecht W, Andersen G, Piskur J, et al
BIOCHEMISTRY 2003;42(19):5706-12

Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
Van Rompay Ar, Johansson M, Karlsson A
PHARMACOLOGY & THERAPEUTICS 2003;100(2):119-39

The Drosophila melanogaster UMP-CMP kinase cDNA encodes an N-terminal mitochondrial import signal
Curbo S, Amiri M, Foroogh F, Johansson M, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;311(2):440-5

Transfer of the Drosophila melanogaster multisubstrate deoxyribonucleoside kinase gene in hepatoma cells.
Altmann A, Karlsson A, Peschke P, Mason Rp, Haberkorn U
JOURNAL OF NUCLEAR MEDICINE 2003;44(5):371P-371P

Acyclic nucleoside analogues as novel inhibitors of human mitochondrial thymidine kinase
Hernandez Ai, Balzarini J, Karlsson A, Camarasa Mj, Perez-perez Mj
JOURNAL OF MEDICINAL CHEMISTRY 2002;45(19):4254-63

Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase
Schneider B, Norda A, Karlsson A, Veron M, Deville-bonnie D
PROTEIN SCIENCE 2002;11(7):1648-56

2 '-O-acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase
Balzarini J, Degreve B, Zhu Cy, Durini E, Porcu L, De Clercq E, et al
BIOCHEMICAL PHARMACOLOGY 2001;61(6):727-732

Bystander effects of cancer cell lines transduced with the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster and synergistic enhancement by hydroxyurea
Zheng Xy, Johansson M, Karlsson A
MOLECULAR PHARMACOLOGY 2001;60(2):262-6

Bystander effects of nucleoside analogs phosphorylated in the cytosol or mitochondria
Sanda A, Zhu Cy, Johansson M, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2001;287(5):1163-6

Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors
Manfredini S, Baraldi Pg, Durini E, Porcu L, Angusti A, Vertuani S, et al
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2001;11(10):1329-32

Dual mechanisms of 9-beta-D-arabinofuranosylguanine resistance in CEM T-lymphoblast leukemia cells
Curbo S, Zhu Cy, Johansson M, Balzarini J, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2001;285(1):40-5

Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV
Balzarini J, Camarasa Mj, Perez-perez Mj, San-fleix A, Velazquez S, Perno Cf, et al
JOURNAL OF VIROLOGY 2001;75(13):5772-7

Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol
Zheng Xy, Johansson M, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2001;289(1):229-33

Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol
Zheng Xy, Johansson M, Karlsson A
CANCER GENE THERAPY 2001;:S21-S21

Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases
Van Rompay Ar, Norda A, Linden K, Johansson M, Karlsson A
MOLECULAR PHARMACOLOGY 2001;59(5):1181-6

Conserved gene structure and transcription factor sites in the human and mouse deoxycytidine kinase genes
Johansson M, Norda A, Karlsson A
FEBS LETTERS 2000;487(2):209-12

Differential incorporation of 1-beta-D-arabinofuranosylcytosine and 9-beta-D-arabinofuranosylguanine into nuclear and mitochondrial DNA
Zhu Cy, Johansson M, Karlsson A
FEBS LETTERS 2000;474(2-3):129-32

Incorporation of nucleoside analogs into nuclear or mitochondrial DNA is determined by the intracellular phosphorylation site
Zhu Cy, Johansson M, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(35):26727-31

Mammalian 5 '(3 ')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
Rampazzo C, Johansson M, Gallinaro L, Ferraro P, Hellman U, Karlsson A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(8):5409-15

Multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster
Zheng Xy, Johansson M, Karlsson A
CANCER GENE THERAPY 2000;7(10):1390-1391

Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2
Balzarini J, Zhu Cy, De Clercq E, Perez-perez Mj, Chamorro C, Camarasa Mj, et al
BIOCHEMICAL JOURNAL 2000;:167-71

Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
Van Rompay Ar, Johansson M, Karlsson A
PHARMACOLOGY & THERAPEUTICS 2000;87(2-3):189-98

Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase
Zheng Xy, Johansson M, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(50):39125-9

The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase
Milon L, Meyer P, Chiadmi M, Munier A, Johansson M, Karlsson A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(19):14264-72

The multifunctional deoxynucleoside kinase of insect cells is a target for the development of new insecticides
Balzarini J, Degreve B, Hatse S, De Clercq E, Breuer M, Johansson M, et al
MOLECULAR PHARMACOLOGY 2000;57(4):811-9

The subcellular location of nucleoside analog phosphorylation is a determinant of synergistic effects of hydroxyurea
Zhu Cy, Johansson M, Karlsson A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2000;276(1):179-82

5 '-phosphoramidates and 5 '-diphosphates of 2 '-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: Inhibition of ribonucleotide reductase
Manfredini S, Baraldi Pg, Durini E, Vertuani S, Balzarini J, De Clercq E, et al
JOURNAL OF MEDICINAL CHEMISTRY 1999;42(17):3243-50

Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster
Johansson M, Van Rompay Ar, Degreve B, Balzarini J, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 1999;274(34):23814-9

Cloning of mouse mitochondrial thymidine kinase 2 cDNA
Wettin K, Johansson M, Zheng Xy, Zhu Cy, Karlsson A
FEBS LETTERS 1999;460(1):103-6

Identification of a novel human adenylate kinase - cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein
Van Rompay Ar, Johansson M, Karlsson A
EUROPEAN JOURNAL OF BIOCHEMISTRY 1999;261(2):509-17

Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: Molecular characterization of the human enzyme
Van Rompay Ar, Johansson M, Karlsson A
MOLECULAR PHARMACOLOGY 1999;56(3):562-9

Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5 '-phosphoramidates and 5 '-diphosphates, of 2 '-O-allyl-arabinofuranosyl nucleosides
Manfredini S, Baraldi Pg, Durini E, Balzarini J, De Clercq E, Karlsson A, et al
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS 1999;18(4-5):1007-8

Differential intracellular compartmentalization of herpetic thymidine kinases (TKs) in TK gene-transfected tumor cells: Molecular characterization of the nuclear localization signal of herpes simplex virus type 1 TK
Degreve B, Johansson M, De Clercq E, Karlsson A, Balzarini J
JOURNAL OF VIROLOGY 1998;72(12):9535-43

Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines
Zhu Cy, Johansson M, Permert J, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 1998;273(24):14707-11

Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine, a potent inhibitor of herpesvirus replication
Neyts J, Balzarini J, Andrei G, Zhu Cy, Snoeck R, Zimmermann A, et al
MOLECULAR PHARMACOLOGY 1998;53(1):157-65

Phosphorylation of anticancer nucleoside analogs by human mitochondrial deoxyguanosine kinase
Zhu Cy, Johansson M, Permert J, Karlsson A
BIOCHEMICAL PHARMACOLOGY 1998;56(8):1035-40

Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1
Pelemans H, Esnouf R, Dunkler A, Parniak Ma, Vandamme Am, Karlsson A, et al
JOURNAL OF VIROLOGY 1997;71(11):8195-203

Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2
Johansson M, Karlsson A
JOURNAL OF BIOLOGICAL CHEMISTRY 1997;272(13):8454-8

Human deoxycytidine kinase is located in the cell nucleus
Johansson M, Brismar S, Karlsson A
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1997;94(22):11941-5

Reverse transcriptase fidelity and HIV-1 variation
Balzarini J, Pelemans H, Declercq E, Karlsson A, Kleim Jp
SCIENCE 1997;275(5297):229-30

Cloning and expression of human deoxyguanosine kinase cDNA
Johansson M, Karlsson A
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(14):7258-62

Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors
Balzarini J, Pelemans H, Karlsson A, Declercq E, Kleim Jp
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(23):13152-7

Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication
Balzarini J, Pelemans H, Aquaro S, Perno Cf, Witvrouw M, Schols D, et al
MOLECULAR PHARMACOLOGY 1996;50(2):394-401

Localization of the human deoxyguanosine kinase gene (DGUOK) to chromosome 2p13
Johansson M, Bajalicalagercrantz S, Lagercrantz J, Karlsson A
GENOMICS 1996;38(3):450-1

Marked inhibitory activity of non-nucleoside reverse transcriptase inhibitors against human immunodeficiency virus type 1 when combined with (-)2',3'-dideoxy-3'-thiacytidine
Balzarini J, Pelemans H, Perezperez Mj, Sanfelix A, Camarasa Mj, Declercq E, et al
MOLECULAR PHARMACOLOGY 1996;49(5):882-90

Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives
Balzarini J, Karlsson A, Aquaro S, Perno Cf, Cahard D, Naesens L, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1996;93(14):7295-9

ACTIVITY OF VARIOUS THIOCARBOXANILIDE DERIVATIVES AGAINST WILD-TYPE AND SEVERAL MUTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 STRAINS
Balzarini J, Brouwer Wg, Felauer Ee, Declercq E, Karlsson A
ANTIVIRAL RESEARCH 1995;27(3):219-36

Combination of 3TC with non-nucleoside reverse transcriptase inhibitors greatly increases the activity of the inhibitors against human immunodeficiency virus type 1 in cell culture
Balzarini J, Pelemans H, Declercq E, Camarasa Mj, Karlsson A
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY 1995;:16-16

DECREASED THYMIDINE KINASE LEVELS IN PERIPHERAL-BLOOD CELLS FROM HIV-SEROPOSITIVE INDIVIDUALS - IMPLICATIONS FOR ZIDOVUDINE METABOLISM
Jacobsson B, Britton S, He Qm, Karlsson A, Eriksson S
AIDS RESEARCH AND HUMAN RETROVIRUSES 1995;11(7):805-11

DIFFERENCES IN KINETIC-PROPERTIES OF PURE RECOMBINANT HUMAN AND MOUSE DEOXYCYTIDINE KINASE
Johansson M, Karlsson A
BIOCHEMICAL PHARMACOLOGY 1995;50(2):163-8

IN SEARCH OF THE IDEAL DRUG CANDIDATE AMONG THE THIOCARBOXANILIDE CLASS OF NONNUCLEOSIDE REVERSE-TRANSCRIPTASE INHIBITORS (NNRTIS)
Declercq E, Balzarini J, Karlsson A
AIDS RESEARCH AND HUMAN RETROVIRUSES 1995;:S169-S169

OXATHIIN CARBOXANILIDE DERIVATIVES - A CLASS OF NONNUCLEOSIDE HIV-1-SPECIFIC REVERSE-TRANSCRIPTASE INHIBITORS (NNRTIS) THAT ARE ACTIVE AGAINST MUTANT HIV-1 STRAINS RESISTANT TO OTHER NNRTIS
Balzarini J, Jonckheere H, Harrison Wa, Dao Dc, Anne J, Declercq E, et al
ANTIVIRAL CHEMISTRY & CHEMOTHERAPY 1995;6(3):169-178

SUPPRESSION OF THE BREAKTHROUGH OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) IN CELL-CULTURE BY THIOCARBOXANILIDE DERIVATIVES WHEN USED INDIVIDUALLY OR IN COMBINATION WITH OTHER HIV-1 SPECIFIC INHIBITORS (IE, TSAO DERIVATIVES)
Balzarini J, Perezperez Mj, Velazquez S, Sanfelix A, Camarasa Mj, Declercq E, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1995;92(12):5470-4

TSAO DERIVATIVES - HIGHLY SPECIFIC INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) REPLICATION
Camarasa Mj, Perezperez Mj, Velazquez S, Sanfelix A, Alvarez R, Ingate S, et al
NUCLEOSIDES & NUCLEOTIDES 1995;14(3-5):585-594

Show all publications