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Publications

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer
Baldini N, De Milito A, Feron O, Gillies Rj, Michiels C, Otto Am, et al
Frontiers in pharmacology 2017;8():411-

Pathobiology and Therapeutic Implications of Tumor Acidosis
Viklund J, Avnet S, De Milito A
Current medicinal chemistry 2017;24(26):2827-2845

Therapeutic implications of tumor interstitial acidification
Kolosenko I, Avnet S, Baldini N, Viklund J, De Milito A
Seminars in cancer biology 2017;43():119-133

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
Avnet S, Lemma S, Cortini M, Pellegrini P, Perut F, Zini N, et al
Oncotarget 2016;7(39):63408-63423

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics
Zhang X, De Milito A, Demiroglu-zergeroglu A, Gullbo J, D'arcy P, Linder S
Trends in cancer 2016;2(11):657-663

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages
Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin Np, et al
Cancer research 2016;76(11):3166-78

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky Dj, Abdelmohsen K, Abe A, Abedin Mj, Abeliovich H, Acevedo Arozena A, et al
Autophagy 2016;12(1):1-222

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells
Sbrana Fv, Cortini M, Avnet S, Perut F, Columbaro M, De Milito A, et al
Stem cell reviews 2016;12(6):621-633

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells
Pellegrini P, Dyczynski M, Sbrana Fv, Karlgren M, Buoncervello M, Hagg-olofsson M, et al
ONCOTARGET 2016;7(24):35703-35723

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
Kolosenko I, Fryknäs M, Forsberg S, Johnsson P, Cheon H, Holvey-bates Eg, et al
International journal of cancer 2015;136(4):E51-61

Proton channels and exchangers in cancer
Spugnini Ep, Sonveaux P, Stock C, Perez-sayans M, De Milito A, Avnet S, et al
Biochimica et biophysica acta 2015;1848(10 Pt B):2715-26

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
Zhang X, De Milito A, Olofsson Mh, Gullbo J, D'arcy P, Linder S
International journal of molecular sciences 2015;16(11):27313-26

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies
Pellegrini P, Strambi A, Zipoli C, Hägg-olofsson M, Buoncervello M, Linder S, et al
Autophagy 2014;10(4):562-71

Autophagy researchers
Agostinis P, De Milito A, Esclatine A, Simon Hu
AUTOPHAGY 2014;10(9):1483-6

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson Mh, et al
Nature communications 2014;5():3295-

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter
Aftab O, Fryknäs M, Zhang X, De Milito A, Hammerling U, Linder S, et al
Autophagy 2014;10(1):57-69

SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
Ma L, Maruwge W, Strambi A, D'arcy P, Pellegrini P, Kis L, et al
Cell death & disease 2014;5():e1483-

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors
Bellone M, Calcinotto A, Filipazzi P, De Milito A, Fais S, Rivoltini L
ONCOIMMUNOLOGY 2013;2(1):e22058-

A Rationale for the Use of Proton Pump Inhibitors as Antineoplastic Agents
De Milito A, Marino Ml, Fais S
CURRENT PHARMACEUTICAL DESIGN 2012;18(10):1395-406

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress
Marino Ml, Pellegrini P, Di Lernia G, Djavaheri-mergny M, Brnjic S, Zhang Xn, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(36):30664-76

Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky Dj, Abdalla Fc, Abeliovich H, Abraham Rt, Acevedo-arozena A, Adeli K, et al
AUTOPHAGY 2012;8(4):445-544

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes
Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, et al
CANCER RESEARCH 2012;72(11):2746-56

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma
Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, et al
INTERNATIONAL JOURNAL OF CANCER 2012;130(12):2824-34

Soluble CD27 induces IgG production through activation of antigen-primed B cells
Dang Lvp, Nilsson A, Ingelman-sundberg H, Cagigi A, Gelinck Lbs, Titanji K, et al
JOURNAL OF INTERNAL MEDICINE 2012;271(3):282-93

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
Hernlund E, Olofsson Mh, Fayad W, Fryknas M, Lesiak-mieczkowska K, Zhang Xn, et al
EUROPEAN JOURNAL OF CANCER 2012;48(3):396-406

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
De Milito A, Canese R, Marino Ml, Borghi M, Iero M, Villa A, et al
INTERNATIONAL JOURNAL OF CANCER 2010;127(1):207-19

Proton dynamics in cancer
Huber V, De Milito A, Harguindey S, Reshkin Sj, Wahl Ml, Rauch C, et al
JOURNAL OF TRANSLATIONAL MEDICINE 2010;:57-

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells
Marino Ml, Fais S, Djavaheri-mergny M, Villa A, Meschini S, Lozupone F, et al
CELL DEATH & DISEASE 2010;:e87-

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients
Logozzi M, De Milito A, Lugini L, Borghi M, Calabro L, Spada M, et al
PLOS ONE 2009;4(4):e5219-

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells
Muratori C, Cavallin Le, Kratzel K, Tinari A, De Milito A, Fais S, et al
CELL HOST & MICROBE 2009;6(3):218-30

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells
Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, De Milito A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2009;284(49):34211-22

Pleiotropic function of ezrin in human metastatic melanomas
Federici C, Brambilla D, Lozupone F, Matarrese P, De Milito A, Lugini L, et al
INTERNATIONAL JOURNAL OF CANCER 2009;124(12):2804-12

Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells
You Hy, Jin J, Shu Hq, Yu B, De Milito A, Lozupone F, et al
CANCER LETTERS 2009;280(1):110-9

The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells
Lozupone F, Perdicchio M, Brambilla D, Borghi M, Meschini S, Barca S, et al
EMBO REPORTS 2009;10(12):1348-54

Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection
Titanji K, Sammicheli S, De Milito A, Mantegani P, Fortis C, Berg L, et al
IMMUNOLOGY 2008;123(2):164-70

B cell immunopathology during HIV-1 infection: Lessons to learn for HIV-1 vaccine design
Cagigi A, Nilsson A, De Milito A, Chiodi F
VACCINE 2008;26(24):3016-25

Fluorescence resonance energy transfer (FRET) as a useful tool in studying CD95/FAS-ezrin association during lymphocyte activation
Gambardella L, Ascione B, Ciarlo L, Vona R, Strudthoff T, De Milito A, et al
CYTOMETRY PART A 2008;73A(1):93-94

The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells
Meschini S, Condello M, Calcabrini A, Marra M, Formisano G, Lista P, et al
AUTOPHAGY 2008;4(8):1020-33

FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major
Eidsmo L, Fluur C, Rethi B, Ygberg Se, Ruffin N, De Milito A, et al
AMERICAN JOURNAL OF PATHOLOGY 2007;170(1):227-39

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
Fluur C, De Milito A, Fry Tj, Vivar N, Eidsmo L, Atlas A, et al
JOURNAL OF IMMUNOLOGY 2007;178(8):5340-50

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species
De Milito A, Iessi E, Logozzi M, Lozupone F, Spada M, Marino Ml, et al
CANCER RESEARCH 2007;67(11):5408-17

Targeting vacuolar H+-ATPases as a new strategy against cancer
Fais S, De Milito A, You Hy, Qin Wx
CANCER RESEARCH 2007;67(22):10627-30

Altered role of interleukin-7 in T-cell homeostasis during HIV-infection.
Rethi B, Fluur C, De Milito A, Atlas A, Grutzmeier S, Rajnavolgyi E, et al
CLINICAL IMMUNOLOGY 2006;:S13-S13

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection
Titanji K, De Milito A, Cagigi A, Thorstensson R, Grutzmeier S, Atlas A, et al
BLOOD 2006;108(5):1580-7

Expression of CD27-CD70 on early B cell progenitors in the bone marrow: Implication for diagnosis and therapy of childhood ALL
Nilsson A, De Milito A, Mowafi F, Winberg G, Bjork O, Wolpert Ez, et al
EXPERIMENTAL HEMATOLOGY 2005;33(12):1500-7

Loss of IL-7Ra is associated with CD4+T cell depletion, high IL-7 levels and CD28 down-regulation in HIV infected patients
Rethi B, Fluur C, Atlas A, Grutzmeier S, De Milito A, Rajnavolgyi E, et al
RETROVIROLOGY 2005;:-

Loss of IL-7R alpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients
Rethi B, Fluur C, Atlas A, Krzyzowska M, Mowafi F, Grutzmeier S, et al
AIDS 2005;19(18):2077-86

Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
Titanji K, Chiodi F, Bellocco R, Schepis D, Cagigi A, Osorio L, et al
RETROVIROLOGY 2005;:-

Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions
Titanji K, Chiodi F, Bellocco R, Schepis D, Osorio L, Tassandin C, et al
AIDS 2005;19(17):1947-55

Proton pump inhibitors may reduce tumour resistance
De Milito A, Fais S
EXPERT OPINION ON PHARMACOTHERAPY 2005;6(7):1049-54

The role of FAS to ezrin association in FAS-mediated apoptosis
Fais S, De Milito A, Lozupone F
APOPTOSIS 2005;10(5):941-7

Tumor acidity, chemoresistance and proton pump inhibitors
De Milito A, Fais S
Future oncology (London, England) 2005;1(6):779-86

B lymphocyte dysfunctions in HIV infection
De Milito A
CURRENT HIV RESEARCH 2004;2(1):11-21

Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
Luciani F, Spada M, De Milito A, Molinari A, Rivoltini L, Montinaro A, et al
JOURNAL OF THE NATIONAL CANCER INSTITUTE 2004;96(22):1702-13

Effects of potent Antiretroviral therapy on the immune activation marker soluble CD27 in patients infected with HIV-1 subtypes A-D
Atlas A, Ha Ttt, Lindstrom A, Nilsson A, Alaeus A, Chiodi F, et al
JOURNAL OF MEDICAL VIROLOGY 2004;72(3):345-51

Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M, et al
BLOOD 2004;103(6):2180-6

Astrocyte activation and apoptosis: Their roles in the neuropathology of HIV infection
Sabri F, Titanji K, De Milito A, Chiodi F
BRAIN PATHOLOGY 2003;13(1):84-94

Low frequency of plasma nerve-growth factor detection is associated with death of memory B lymphocytes in HIV-1 infection
Titanji K, Nilsson A, Morch C, Samuelsson A, Sonnerborg A, Grutzmeier S, et al
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2003;132(2):297-303

Plasma levels of soluble CD27: a simple marker to monitor immune activation during potent antiretroviral therapy in HIV-1-infected subjects (vol 127, pg 486, 2002)
De Milito A, Aleman S, Marenzi R, Sonnerborg A, Fuchs D, Zazzi M, et al
CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2003;134(1):167-167

Surrogate markers as a guide to evaluate response to antiretroviral therapy
De Milito A, Titanji K, Zazzi M
CURRENT MEDICINAL CHEMISTRY 2003;10(5):349-65

Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens
Nilsson A, De Milito A, Engstrom P, Nordin M, Narita M, Grillner L, et al
PEDIATRICS 2002;109(6):e91-

Cross-linking of LFA-1 molecule enhances Fas mediated apoptosis of Jurkat and Burkitt lymphoma cell lines
Krzyzowska M, Sabri F, De Milito A, Missailidis C, Schollenberger A, Niemialtowski Mg, et al
CELL DEATH AND DIFFERENTIATION 2001;8(11):1123-4

Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex
Sabri F, De Milito A, Pirskanen R, Elovaara I, Hagberg L, Cinque P, et al
JOURNAL OF NEUROIMMUNOLOGY 2001;114(1-2):197-206

Loss of memory (CD27) B lymphocytes in HIV-1 infection
De Milito A, Morch C, Sonnerborg As, Chiodi F
AIDS 2001;15(8):957-64

Soluble CD23 in cerebrospinal fluid: a marker of AIDS-related non-Hodgkin's lymphoma in the brain
Bossolasco S, Nilsson A, De Milito A, Lazzarin A, Linde A, Cinque P, et al
AIDS 2001;15(9):1109-13

[Cytostatic therapy reduces the immune defense. Children treated for leukemia have impaired immunity against measles and rubella]
Nilsson A, Nordin M, De Milito A, Grillner L, Chiodi F, Björk O
Lakartidningen 2000;97(45):5116-8

High plasma levels of soluble Fas in HIV type 1-infected subjects are not normalized during highly active antiretroviral therapy
De Milito A, Hejdeman B, Albert J, Aleman S, Sonnerborg A, Zazzi M, et al
AIDS RESEARCH AND HUMAN RETROVIRUSES 2000;16(14):1379-84

Antiretroviral therapy with protease inhibitors in human immunodeficiency virus type 1- and human herpesvirus 8-coinfected patients
De Milito A, Catucci M, Venturi G, Romano L, Incandela L, Valensin Pe, et al
JOURNAL OF MEDICAL VIROLOGY 1999;57(2):140-4

Clinical evaluation of an in-house reverse transcription competitive PCR for quantitation of human immunodeficiency virus type 1 RNA in plasma
Zazzi M, Romano L, Catucci M, Venturi G, De Milito A, Valensin Pe
JOURNAL OF CLINICAL MICROBIOLOGY 1999;37(2):333-8

Development and significance of the HIV-1 reverse transcriptase M184V mutation during combination therapy with lamivudine, zidovudine, and protease inhibitors
Catucci M, Venturi G, Romano L, Riccio Ml, De Milito A, Valensin Pe, et al
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 1999;21(3):203-8

Evaluation of cell-free and cell-associated peripheral blood human immunodeficiency virus type 1 RNA response to antiretroviral therapy
Romano L, Venturi G, Catucci M, De Milito A, Valensin Pe, Zazzi M
JOURNAL OF INFECTIOUS DISEASES 1999;179(2):361-6

Genotypic resistance to zidovudine as a predictor of failure of subsequent therapy with human immunodeficiency virus type-1 nucleoside reverse-transcriptase inhibitors
Venturi G, Romano L, Catucci M, Riccio Ml, De Milito A, Gonnelli A, et al
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 1999;18(4):274-82

Detection of human herpesviruses 6 and 7 in heart transplant recipients by a multiplex polymerase chain reaction method
Moschettini D, De Milito A, Catucci M, Marconi A, Rinina C, Bianchi-bandinelli Ml, et al
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 1998;17(2):117-9

Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant
Bosi A, Zazzi M, Amantini A, Cellerini M, Vannucchi Am, De Milito A, et al
BONE MARROW TRANSPLANTATION 1998;22(3):285-8

HIV-associated malignant lymphomas in Kenya (Equatorial Africa)
Lazzi S, Ferrari F, Nyongo A, Palummo N, De Milito A, Zazzi M, et al
HUMAN PATHOLOGY 1998;29(11):1285-9

Long-read direct infrared sequencing of crude PCR products for prediction of resistance to HIV-1 reverse transcriptase and protease inhibitors
Zazzi M, Riccio Ml, Venturi G, Catucci M, Romano L, De Milito A, et al
MOLECULAR BIOTECHNOLOGY 1998;10(1):1-8

Nerve growth factor released by CD40 ligand-transfected L cells: Implications for functional and phenotypic studies on CD40(+) cells
De Milito A, Nagy N, Samuelsson A, Chiodi F, Rajnavolgyi E
BLOOD 1998;92(11):4482-4

Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression
Zazzi M, Romano L, Catucci M, Venturi G, Demilito A, Almi P, et al
JOURNAL OF MEDICAL VIROLOGY 1997;52(1):20-5

Lack of evidence of HHV-8 DNA in blood cells from heart transplant recipients
Demilito A, Venturi G, Catucci M, Romano L, Bandinelli Mlb, Zazzi M
BLOOD 1997;89(5):1837-8

Human immunodeficiency virus-1 infection, homosexuality, and Kaposi-associated herpes-like DNA in peripheral blood mononuclear cells
Demilito A, Catucci M, Venturi G, Romano L, Valensin Pe, Zazzi M, et al
BLOOD 1996;87(8):3521-2

Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: Longitudinal evaluation of six patients under treatment
Zazzi M, Catucci M, Demilito A, Romano L, Venturi G, Almi P, et al
INFECTION 1996;24(6):419-25

Concordance between polymerase chain reaction and antibody detection in the diagnosis of human immunodeficiency virus type 1 infection
Romano L, Catucci M, Demilito A, Venturi G, Zazzi M, Almi P, et al
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 1995;14(11):1011-14

IDENTIFICATION OF MYCOBACTERIUM-TUBERCULOSIS COMPLEX, MYCOBACTERIUM-AVIUM AND MYCOBACTERIUM-INTRACELLULARE BY SELECTIVE NESTED POLYMERASE CHAIN-REACTION
Oggioni Mr, Fattorini L, Li B, Demilito A, Zazzi M, Pozzi G, et al
MOLECULAR AND CELLULAR PROBES 1995;9(5):321-6

INCREASED RELIABILITY OF SELECTIVE PCR BY USING ADDITIONALLY MUTATED PRIMERS AND A COMMERCIAL TAQ DNA-POLYMERASE ENHANCER
Demilito A, Catucci M, Iannelli F, Romano L, Zazzi M, Valensin Pe
MOLECULAR BIOTECHNOLOGY 1995;3(2):166-9

LOW HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) DNA BURDEN AS A MAJOR CAUSE FOR FAILURE TO DETECT HIV-1 DNA IN CLINICAL SPECIMENS BY PCR
Zazzi M, Romano L, Catucci M, Demilito A, Almi P, Gonnelli A, et al
JOURNAL OF CLINICAL MICROBIOLOGY 1995;33(1):205-8

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