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About me

I am associate professor in experimental dermatology (since 2011). My group is located at the Center for Molecular Medicine, Solna.

Research description

Our research is focused on skin non-coding RNAs (ncRNAs), in particular we investigate their involvement in the malignant transformation of skin cells as well as in the modulation of the innate immune response in the skin.

 

1. Investigation of the role of non-coding RNAs in skin cancer

Non-melanoma skin cancers, basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are the most common cancers in human. Until recently, very little was known about the expression and function of ncRNAs in human skin and its diseases. Non-melanoma skin cancers are primarily a consequence of cumulate sun exposure, which results in genetic and epigenetic changes leading to acquiring a cancer-phenotype. Although the genetic alterations contributing to non-melanoma skin cancers have been extensively characterized, the factors responsible for mediating their effects on cellular transformation, reprogramming of the tumor microenvironment is less known. Recently, ncRNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have emerged as novel regulators of genetic programs in higher eukaryotes. My team has identified several non-coding RNAs that are expressed in the skin, however, their contribution to skin carcinogenesis remains poorly understood.

 

Our aims are to (1) identify non-coding RNAs, microRNAs and long non-coding RNAs, that are involved in skin cancer (2) to identify the biochemical regulatory networks leading to their altered expression (3) to decipher their roles in the neoplastic transformation of skin epithelial cells (4) identify their roles in the regulation of gene networks.  We study the molecular function and the pathways regulating their expression using cell culture assays and investigate their function in skin cancer and inflammation using animal disease models such as genetically modified animals, cancer growth and metastasis assays. Our long-term goal is to translate our findings into the clinical practice and modulate miRNA expression in the skin via synthetic miRNAs or miRNA inhibitors in order to treat skin cancer.

 

2. Investigation of the role of non-coding RNAs in the innate immunity in the skin

Another line of research in the lab is the investigation of the role non-coding RNAs in the innate immune response of skin cells. Healthy skin is colonized by bacteria, which are essential for the maintenance of heathy tissue homeostasis. My earlier research demonstrated that skin cells are able to recognize danger signals and upon activation keratinocytes they organize an immune response via the secretion of inflammatory mediators and chemokines. Although the trancriptomic changes assacoited with the innate immune response of skin cells has been chaeracteries, little has been known whenther and how these molecular alterations are regualted by ncRNAs. Our aim is to explore the role of non-coding RNAs in the regulation of the innate immune response of keratinocytes.

Publications

MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing
Li X, Li D, Wikstrom Jd, Pivarcsi A, Sonkoly E, Ståhle M, et al
Scientific reports 2017;7(1):7797-

MicroRNA-132 with Therapeutic Potential in Chronic Wounds
Li X, Li D, Wang A, Chu T, Lohcharoenkal W, Zheng X, et al
The Journal of investigative dermatology 2017;137(12):2630-2638

MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis
Srivastava A, Nikamo P, Lohcharoenkal W, Li D, Meisgen F, Xu Landén N, et al
The Journal of allergy and clinical immunology 2017;139(2):550-561

MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC
Lohcharoenkal W, Harada M, Lovén J, Meisgen F, Landén Nx, Zhang L, et al
The Journal of investigative dermatology 2016;136(12):2485-2494

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing
Li D, Wang A, Liu X, Meisgen F, Grünler J, Botusan Ir, et al
The Journal of clinical investigation 2015;125(8):3008-26

MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration
Li D, Li Xi, Wang A, Meisgen F, Pivarcsi A, Sonkoly E, et al
The Journal of investigative dermatology 2015;135(6):1676-1685

Activation of toll-like receptors alters the microRNA expression profile of keratinocytes
Meisgen F, Xu Landén N, Bouez C, Zuccolo M, Gueniche A, Ståhle M, et al
Experimental dermatology 2014;23(4):281-3

Genetic polymorphisms altering microRNA activity in psoriasis--a key to solve the puzzle of missing heritability?
Pivarcsi A, Ståhle M, Sonkoly E
Experimental dermatology 2014;23(9):620-4

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1
Villegas Ve, Rahman Mf, Fernandez-barrena Mg, Diao Y, Liapi E, Sonkoly E, et al
Molecular oncology 2014;8(5):912-26

MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells
Wang A, Landén Nx, Meisgen F, Lohcharoenkal W, Ståhle M, Sonkoly E, et al
PloS one 2014;9(7):e103206-

MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes
Meisgen F, Xu Landén N, Wang A, Réthi B, Bouez C, Zuccolo M, et al
The Journal of investigative dermatology 2014;134(7):1931-1940

miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma
Gastaldi C, Bertero T, Xu N, Bourget-ponzio I, Lebrigand K, Fourre S, et al
Carcinogenesis 2014;35(5):1110-20

Are BIC (miR-155) polymorphisms associated with eczema susceptibility?
Sääf A, Kockum I, Wahlgren Cf, Xu N, Sonkoly E, Ståhle M, et al
Acta dermato-venereologica 2013;93(3):366-7

Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor-α therapy
Pivarcsi A, Meisgen F, Xu N, Ståhle M, Sonkoly E
The British journal of dermatology 2013;169(3):563-70

Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes
Wei T, Xu N, Meisgen F, Ståhle M, Sonkoly E, Pivarcsi A
European journal of dermatology : EJD 2013;():-

Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes
Wei Tl, Xu N, Meisgen F, Stahle M, Sonkoly E, Pivarcsi A
EUROPEAN JOURNAL OF DERMATOLOGY 2013;:66-71

MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40
Xu N, Meisgen F, Butler Lm, Han G, Wang Xj, Söderberg-nauclér C, et al
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):678-88

Next-generation sequencing identifies microRNAs that associate with pathogenic autoimmune neuroinflammation in rats
Bergman P, James T, Kular L, Ruhrmann S, Kramarova T, Kvist A, et al
Journal of immunology (Baltimore, Md. : 1950) 2013;190(8):4066-75

RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
Shimokawa T, Rahman Mf, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, et al
RNA biology 2013;10(2):321-33

Characterization of EGFR and ErbB2 expression in atopic dermatitis patients
Sääf A, Pivarcsi A, Winge Mc, Wahlgren Cf, Homey B, Nordenskjöld M, et al
Archives of dermatological research 2012;304(10):773-80

Constraints for monocyte-derived dendritic cell functions under inflammatory conditions
Fekete T, Szabo A, Beltrame L, Vivar N, Pivarcsi A, Lanyi A, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2012;42(2):458-69

MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion
Xu N, Zhang Ly, Meisgen F, Harada M, Heilborn J, Homey B, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(35):29899-908

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, et al
Oncogenesis 2012;1():e3-

MiR-21 is uip-regulated n psoriasis and suppresses T cell apoptosis
Meisgen F, Xu N, Wei Tl, Janson Pc, Obad S, Broom O, et al
EXPERIMENTAL DERMATOLOGY 2012;21(4):312-4

MicroRNAs in inflammation and response to injuries induced by environmental pollution
Sonkoly E, Pivarcsi A
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 2011;717(1-2):46-53

MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2
Xu N, Brodin P, Wei Tl, Meisgen F, Eidsmo L, Nagy N, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2011;131(7):1521-9

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4
Sonkoly E, Janson P, Majuri Ml, Savinko T, Fyhrquist N, Eidsmo L, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2010;126(3):581-9.e1

MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma
Loven J, Zinin N, Wahlstrom T, Muller I, Brodin P, Fredlund E, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2010;107(4):1553-8

Protein Kinase C-Dependent Upregulation of miR-203 Induces the Differentiation of Human Keratinocytes
Sonkoly E, Wei Tl, Lorie Ep, Suzuki H, Kato M, Torma H, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2010;130(1):124-34

The expression of microRNA-203 during human skin morphogenesis
Wei Tl, Orfanidis K, Xu N, Janson P, Stahle M, Pivarcsi A, et al
EXPERIMENTAL DERMATOLOGY 2010;19(9):854-6

Advances in microRNAs: implications for immunity and inflammatory diseases
Sonkoly E, Pivarcsi A
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 2009;13(1):24-38

A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration
Hoffmann Tk, Schirlau K, Sonkoly E, Brandau S, Lang S, Pivarcsi A, et al
INTERNATIONAL JOURNAL OF CANCER 2009;124(11):2589-96

Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer
Weber G, Chamorro Ci, Granath F, Liljegren A, Zreika S, Saidak Z, et al
BREAST CANCER RESEARCH 2009;11(1):R6-

microRNAs in Inflammation
Sonkoly E, Pivarcsi A
INTERNATIONAL REVIEWS OF IMMUNOLOGY 2009;28(6):535-61

The Human Antimicrobial Peptide LL-37 Suppresses Apoptosis in Keratinocytes
Chamorro Ci, Weber G, Gronberg A, Pivarcsi A, Stahle M
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2009;129(4):937-44

Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis
Belso N, Szell M, Pivarcsi A, Kis K, Kormos B, Kenderessy As, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2008;128(3):634-42

MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation
Sonkoly E, Stahle M, Pivarcsi A
SEMINARS IN CANCER BIOLOGY 2008;18(2):131-40

MicroRNAs: novel regulators in skin inflammation
Sonkoly E, Stahle M, Pivarcsi A
CLINICAL AND EXPERIMENTAL DERMATOLOGY 2008;33(3):312-5

Human adult epidermal melanocytes cultured without chemical mitogens express the EGF receptor and respond to EGF
Szabad G, Kormos B, Pivarcsi A, Szell M, Kis K, Szabo Ak, et al
ARCHIVES OF DERMATOLOGICAL RESEARCH 2007;299(4):191-200

MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
Sonkoly E, Wei Tl, Janson Pcj, Saaf A, Lundeberg L, Tengvall-linder M, et al
PLOS ONE 2007;2(7):e610-

Tumor immune escape by the loss of homeostatic chemokine expression
Pivarcsi A, Muller A, Hippe A, Rieker J, Van Lierop A, Steinhoff M, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007;104(48):19055-60

Budesonide, but not tacrolimus, affects the immune functions of normal human keratinocytes
Kis K, Bodai L, Polyanka H, Eder K, Pivarcsi A, Duda E, et al
INTERNATIONAL IMMUNOPHARMACOLOGY 2006;6(3):358-68

IL-31: A new link between T cells and pruritus in atopic skin inflammation
Sonkoly E, Muller A, Lauerma Ai, Pivarcsi A, Soto H, Kemeny L, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2006;117(2):411-7

Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes
Nagy I, Pivarcsi A, Kis K, Koreck A, Bodai L, Mcdowell A, et al
MICROBES AND INFECTION 2006;8(8):2195-205

The expression of keratinocyte growth factor receptor (FGFR2-IIIb) correlates with the high proliferative rate of HaCaT keratinocytes
Nagy N, Bata-csorgo Z, Kopasz N, Szeg C, Pivarcsi A, Koreck A, et al
EXPERIMENTAL DERMATOLOGY 2006;15(8):596-605

CCL1-CCR8 interactions: An axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation
Gombert M, Dieu-nosjean Mc, Winterberg F, Bunemann E, Kubitza Rc, Da Cunha L, et al
JOURNAL OF IMMUNOLOGY 2005;174(8):5082-91

Chemokine networks in atopic dermatitis: Traffic signals of disease
Pivarcsi A, Homey B
CURRENT ALLERGY AND ASTHMA REPORTS 2005;5(4):284-90

Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through Toll-like receptors
Nagy I, Pivarcsi A, Koreck A, Szell M, Urban E, Kemeny L
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2005;124(5):931-8

Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS
Sonkoly E, Bata-csorgo Z, Pivarcsi A, Polyanka H, Kenderessy-szabo A, Molnar G, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2005;280(25):24159-67

Microbial compounds induce the expression of pro-inflammatory cytokines, chemokines and human beta-defensin-2 in vaginal epithelial cells
Pivarcsi A, Nagy I, Koreck A, Kis K, Kenderessy-szabo A, Szell M, et al
MICROBES AND INFECTION 2005;7(9-10):1117-27

CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure
Pivarcsi A, Gombert M, Dieu-nosjean Mc, Lauerma A, Kubitza R, Meller S, et al
JOURNAL OF IMMUNOLOGY 2004;173(9):5810-7

Differentiation-regulated expression of Toll-like receptors 2 and 4 in HaCaT keratinocytes
Pivarcsi A, Koreck A, Bodai L, Szell M, Szeg C, Belso N, et al
ARCHIVES OF DERMATOLOGICAL RESEARCH 2004;296(3):120-4

Innate immune functions of the keratinocytes. A review
Pivarcsi A, Kemény L, Dobozy A
Acta microbiologica et immunologica Hungarica 2004;51(3):303-10

Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity
Garaczi E, Szell M, Janossy T, Koreck A, Pivarcsi A, Buzas E, et al
INTERNATIONAL IMMUNOLOGY 2004;16(12):1781-8

Proliferating keratinocytes are putative sources of the psoriasis susceptibility-related EDA(+) (dxtra domain a of fibronectin) oncofetal fibronectin
Szell M, Bata-csorgo Z, Koreck A, Pivarcsi A, Polyanka H, Szeg C, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2004;123(3):537-46

Expression and function of Toll-like receptors 2 and 4 in human keratinocytes
Pivarcsi A, Bodai L, Rethi B, Kenderessy-szabo A, Koreck A, Szell M, et al
INTERNATIONAL IMMUNOLOGY 2003;15(6):721-30

Hemese, a hemocyte-specific transmembrane protein, affects the cellular immune response in Drosophila
Kurucz E, Zettervall Cj, Sinka R, Vilmos P, Pivarcsi A, Ekengren S, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2003;100(5):2622-7

A mannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans
Szolnoky G, Bata-csorgo Z, Kenderessy As, Kiss M, Pivarcsi A, Novak Z, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2001;117(2):205-13

Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT
Farkas A, Kemeny L, Szony Bj, Bata-csorgo Z, Pivarcsi A, Kiss M, et al
INFLAMMATION RESEARCH 2001;50(1):44-9

Serum factors regulate the expression of the proliferation-related genes alpha 5 integrin and keratin 1, but not keratin 10, in HaCaT keratinocytes
Pivarcsi A, Szell M, Kemeny L, Dobozy A, Bata-csorgo Z
ARCHIVES OF DERMATOLOGICAL RESEARCH 2001;293(4):206-13

Histidine decarboxylase expression in human melanoma
Haak-frendscho M, Darvas Z, Hegyesi H, Karpati S, Hoffman Rl, Laszlo V, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2000;115(3):345-52

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