Alejandro Gonzalez Alvarez

About me
Publications
Public outreach and news

Research

I use electrophysiological approaches together with optogenetics to study peripheral sensory transduction, and the cellular and molecular mechanisms that lead to the development of pathological conditions like chronic Pain.

Articles

Article: BRAIN. 2023;146(2):475-491

TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy.

Marcotti A; Fernández-Trillo J; González A; Vizcaíno-Escoto M; Ros-Arlanzón P; Romero L; Vela JM; Gomis A; Viana F; de la Peña E
Article: JOURNAL OF NEUROSCIENCE. 2020;40(47):8976-8993

Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea.

Fernández-Trillo J; Florez-Paz D; Íñigo-Portugués A; González-González O; Del Campo AG; González A; Viana F; Belmonte C; Gomis A
Article: JOURNAL OF NEUROSCIENCE. 2019;39(6):949-969

The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels.

Arcas JM; González A; Gers-Barlag K; González-González O; Bech F; Demirkhanyan L; Zakharian E; Belmonte C; Gomis A; Viana F
Article: PHYSIOLOGICAL REPORTS. 2018;6(17):e13852

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels.

Ramracheya R; Chapman C; Chibalina M; Dou H; Miranda C; González A; Moritoh Y; Shigeto M; Zhang Q; Braun M; Clark A; Johnson PR; Rorsman P; Briant LJB
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(32):12454-12471

Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison.

Pertusa M; Rivera B; González A; Ugarte G; Madrid R
Article: DIABETES. 2018;67(6):1128-1139

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic α-Cells.

Hamilton A; Zhang Q; Salehi A; Willems M; Knudsen JG; Ringgaard AK; Chapman CE; Gonzalez-Alvarez A; Surdo NC; Zaccolo M; Basco D; Johnson PRV; Ramracheya R; Rutter GA; Galione A; Rorsman P; Tarasov AI
Article: JOURNAL OF NEUROSCIENCE. 2017;37(12):3109-3126

Role of the Excitability Brake Potassium Current IKD in Cold Allodynia Induced by Chronic Peripheral Nerve Injury.

González A; Ugarte G; Restrepo C; Herrera G; Piña R; Gómez-Sánchez JA; Pertusa M; Orio P; Madrid R
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2017;1015:265-277

IKD Current in Cold Transduction and Damage-Triggered Cold Hypersensitivity.

González A; Herrera G; Ugarte G; Restrepo C; Piña R; Pertusa M; Orio P; Madrid R
Article: SCIENTIFIC REPORTS. 2015;5:11622

Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pancreas to diet-induced obesity.

Merino B; Alonso-Magdalena P; Lluesma M; Ñeco P; Gonzalez A; Marroquí L; García-Arévalo M; Nadal A; Quesada I
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(32):21828-21843

Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain.

Pertusa M; González A; Hardy P; Madrid R; Viana F
Article: CELL METABOLISM. 2013;18(6):871-882

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Zhang Q; Ramracheya R; Lahmann C; Tarasov A; Bengtsson M; Braha O; Braun M; Brereton M; Collins S; Galvanovskis J; Gonzalez A; Groschner LN; Rorsman NJG; Salehi A; Travers ME; Walker JN; Gloyn AL; Gribble F; Johnson PRV; Reimann F; Ashcroft FM; Rorsman P
Article: ENDOCRINOLOGY. 2013;154(10):3515-3524

Insulin hypersecretion in islets from diet-induced hyperinsulinemic obese female mice is associated with several functional adaptations in individual β-cells.

Gonzalez A; Merino B; Marroquí L; Ñeco P; Alonso-Magdalena P; Caballero-Garrido E; Vieira E; Soriano S; Gomis R; Nadal A; Quesada I
Article: ENDOCRINOLOGY. 2012;153(4):1663-1672

Functional and structural adaptations in the pancreatic α-cell and changes in glucagon signaling during protein malnutrition.

Marroquí L; Batista TM; Gonzalez A; Vieira E; Rafacho A; Colleta SJ; Taboga SR; Boschero AC; Nadal A; Carneiro EM; Quesada I
Article: PLOS ONE. 2012;7(3):e32282

Model for glucagon secretion by pancreatic α-cells.

González-Vélez V; Dupont G; Gil A; González A; Quesada I
Article: DIABETOLOGIA. 2011;54(4):843-851

Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets.

Marroquí L; Vieira E; Gonzalez A; Nadal A; Quesada I
Article: ENDOCRINOLOGY. 2010;151(8):3543-3554

Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling.

Soriano S; Gonzalez A; Marroquí L; Tudurí E; Vieira E; Amaral AG; Batista TM; Rafacho A; Boschero AC; Nadal A; Carneiro EM; Quesada I
Article: HFSP JOURNAL. 2010;4(2):52-60

Pancreatic islet cells: a model for calcium-dependent peptide release.

Soria B; Tudurí E; González A; Hmadcha A; Martin F; Nadal A; Quesada I
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1798(3):327-337

A membranotropic region in the C-terminal domain of hepatitis C virus protein NS4B interaction with membranes.

Guillén J; González-Alvarez A; Villalaín J

All other publications

Review: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2012;49(1):R9-17

Role of leptin in the pancreatic β-cell: effects and signaling pathways.

Marroquí L; Gonzalez A; Ñeco P; Caballero-Garrido E; Vieira E; Ripoll C; Nadal A; Quesada I
Review: STEROIDS. 2011;76(9):856-860

Regulation of K(ATP) channel by 17β-estradiol in pancreatic β-cells.

Soriano S; Ripoll C; Fuentes E; Gonzalez A; Alonso-Magdalena P; Ropero AB; Quesada I; Nadal A

Research

Articles

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