Scientific publications

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Marutle A, Gillberg PG, Bergfors A, Yu W, Ni R, Nennesmo I, Voytenko L, Nordberg A. (2013). ³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar ²-amyloid in Alzheimer brain. J Neuroinflammation. 2013 Jul 23;10:90. doi: 10.1186/1742-2094-10-90.

Vijayaraghavan, S., Maetzler, W., Reimold, M., Lithner, C. U., Liepelt-Scarfone, I., Berg, D., & Darreh-Shori, T. (2013). High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia. Alzheimers & dementia: the journal of the Alzheimer's Association, 112. doi:10.1016/j.jalz.2013.03.010

Vijayaraghavan, S., Karami, A., Aeinehband, S., Behbahani, H., Grandien, A., Nilsson, B., & Darreh-Shori, T. (2013). Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway. PloS one, 8(6), e65936. doi:10.1371/journal.pone.0065936

Ni R, Gillberg PG, Bergfors A, Marutle A, Nordberg A. Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue. Brain. 2013 Jun 11. [Epub ahead of print]

Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM. Disruption of neocortical histone H3 homeostasis by soluble A²: implications for Alzheimer's disease. Neurobiol Aging. 2013 Apr 9. pii: S0197-4580(12)00661-6. doi: 10.1016/j.neurobiolaging.2012.12.028. [Epub ahead of print]

Taher Darreh-Shori, Swetha Vijayaraghavan, Shahin Aeinehband, Fredrik Piehl, Rickard P.F. Lindblom, Bo Nilsson, Kristina N. Ekdahl, Bengt Långström, Ove Almkvist, Agneta Nordberg. Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimers disease. Neurobiology of Aging (2013) 1-17.

Lilja AM, Röjdner J, Mustafiz T, Thomé CM, Storelli E, Gonzalez D, Unger-Lithner C, Greig NH, Nordberg A, Marutle A. Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-² Levels. PLoS One. 2013;8(3):e58752. doi: 10.1371/journal.pone.0058752. Epub 2013 Mar 15.

Prestia A, Caroli A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall AE, Carter SF, Schöll M, Choo IH, Nordberg A, Scheltens P, Frisoni GB. Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease. Neurology. 2013 Mar 12;80(11):1048-1056. Epub 2013 Feb 6.

Lilja AM, Luo Y, Yu QS, Röjdner J, Li Y, Marini AM, Marutle A, Nordberg A, Greig NH. Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease. PLoS One. 2013;8(1):e54887. doi: 10.1371/journal.pone.0054887. Epub 2013 Jan 30.

Edison P, Carter SF, Rinne JO, Gelosa G, Herholz K, Nordberg A, Brooks DJ, Hinz R. Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET. Neuroimage. 2013 Apr 15;70:423-33. doi: 10.1016/j.neuroimage.2012.12.014. Epub 2012 Dec 20.

Choo IH, Ni R, Schöll M, Wall A, Almkvist O, Nordberg A. Combination of 18F-FDG PET and Cerebrospinal Fluid Biomarkers as a Better Predictor of the Progression to Alzheimer's Disease in Mild Cognitive Impairment Patients. J Alzheimers Dis. 2013 Jan 1;33(4):929-39. Epub 2012 Oct 9.

Ni R, Marutle A, Nordberg A. Modulation of a7 Nicotinic Acetylcholine Receptor and Fibrillar Amyloid-ß Interactions in Alzheimer's Disease Brain. J Alzheimers Dis. 2013 Jan 1;33(3):841-51. Epub 2012 Oct 5.

Nordberg A, Carter SF, Rinne J, Drzezga A, Brooks DJ, Vandenberghe R, Perani D, Forsberg A, Långström B, Scheinin N, Karrasch M, Någren K, Grimmer T, Miederer I, Edison P, Okello A, Van Laere K, Nelissen N, Vandenbulcke M, Garibotto V, Almkvist O, Kalbe E, Hinz R, Herholz K. A European multicentre PET study of fibrillar amyloid in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):104-14. Epub 2012 Sep 8.


Schöll M, Wall A, Thordardottir S, Ferreira D, Bogdanovic N, Långström B, Almkvist O, Graff C, Nordberg A. Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers. Neurology. 2012 Jul 17;79(3):229-36. Epub 2012 Jun 13.

Jacobs AH, Tavitian B, and the INMiND consortium. Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 2012 Jul;32(7):1393-1415. doi: 10.1038/jcbfm.2012.53. Epub 2012 May 2.

Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A. Different ß-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiol Aging. 2012 Apr;33(4):825.e1-13. Epub 2011 Jun 17.

Eriksdotter-Jönhagen M, Linderoth B, Lind G, Aladellie L, Almkvist O, Andreasen N, Blennow K, Bogdanovic N, Jelic V, Kadir A, Nordberg A, Sundström E, Wahlund LO, Wall A, Wiberg M, Winblad B, Seiger A, Almqvist P, Wahlberg L. Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimers Disease. Dement Geriatr Cogn Disord. 2012;33(1):18-28. Epub 2012 Feb 22.

Forsberg A, Engler H, Blomquist G, Långström B, Nordberg A. The use of PIB-PET as a dual pathological and functional biomarker in AD. Biochim Biophys Acta. 2012 Mar;1822(3):380-5. Epub 2011 Nov 13.

Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, Morris JC, Nordberg A, Petersen RC, Reiman EM, Selkoe DJ, Sperling RA, Van Laere K, Weiner MW, Drzezga A. Aß Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2012 Feb;39(2):209-19. No abstract available.

Kadir A, Almkvist O, Forsberg A, Wall A, Engler H, Långström B, Nordberg A. Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer´s disease. Neurobiol Aging. 2012 Jan;33(1):198.e1-14. Epub 2010 Aug 3.

Carter SF, Schöll M, Almkvist O, Wall A, Engler H, Långström B, Nordberg A. Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG. J Nucl Med. 2012 Jan;53(1):37-46.

Darreh-Shori T, Siawesh M, Mousavi M, Andreasen N, Nordberg A. Apolipoprotein µ4 Modulates Phenotype of Butyrylcholinesterase in CSF of Patients with Alzheimer's Disease. J Alzheimers Dis. J Alzheimers Dis. 2012 Jan 1;28(2):443-58. Epub 2011 Oct 19.


Nordberg A. Molecular imaging in Alzheimer's disease: new perspectives on biomarkers for early diagnosis and drug development. Alzheimers Res Ther. 2011 Dec 2;3(6):34.

Shafaati M, Marutle A, Petersson H, Lovgren-Sandblom A, Olin M, Pikuleva I, Winblad B, Nordberg A, Björkhem I. Marked accumulation fo 27- hydroxycholesterol in the brain of Alzheimer patients with the Swedish APP 670/671 mutation. J Lipid Res. 2011 May;52(5):1004-10. Epub 2011 Feb 19.

Schöll M, Almkvist O, Bogdanovic N, Wall A, Långström B, Viitanen M, Nordberg A. Time course of glucose metabolism in relation to cognitive perfornance and postmortem neuropathology in Met146ValPSEN1 mutation carriers. J Alzheimers Dis. 2011;24:495-506. Epub 2011 Feb 1.

Unger-Lithner C, Hedberg M, Nordberg A. Transgenic mice as a model for Alzheimer's disease. Curr Alzheimer Res. 2011 Dec 1;8(8):818-31. 2010, in press.

Mustafiz T, Portelius E, Gustavsson MK, Hölttä M, Zetterberg H, Blennow K, Nordberg A, Unger Lithner C. Characterization of the brain ß-amyloid isoform pattern at different ages of Tg 2576 mice. Neurodegener Dis. 2011;8(5):352-63. Epub 2011 Feb 23.

Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A. Functional interactions of a7 nicotinic receptors in Alzheimer's disease. J Alzheimers Dis 2011;23:335-47.

Keller C, Kadir A, Forsberg A, Porras O, Nordberg A. Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer´s disease patients. J Alzheimers Dis. 2011;24(1):109-23. Epub 2010 Dec 14.

Darreh-Shori T, Forsberg A, Modiri N, Andreasen N, Blennow K, Kamil C, Ahmded H, Almkvist O, Långström B, Nordberg A. Differential levels of apolipoprotein E and buturylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo. Neurobiol Aging. 2011 Dec;32(12):2320.e15-32. Epub 2010 Jun 8.

Schöll M, Almkvist O, Axelman K, Stefanova E, Wall A, Westman E, Långström B, Lannfelt L, Graff C, Nordberg A. Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation. Neurobiol Aging. 2011 Aug;32:1388-99. Epub 2009 Sep 29.

Darreh-Shori T, Modiri N, Blennow K, Baza S, Kamil C, Ahmed H, Andreasen N, Nordberg A. The apolipoprotein E epsilon4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobiol Aging. 2011 Jul;32:1236-48. Epub 2009 Aug 25.

Hampel H, Wilcock G, Andrieu S, Aisen P, Blennow K, Broich K, Carrillo M, Fox NC, Frisoni GB, Isaac M, Lovestone S, Nordberg A, Prvulovic D, Sampaio C, Scheltens P, Weiner M, Winblad B, Coley N, Vellas B; Oxford Task Force Group. Biomarkers for Alzheimer´s disease therapeutic trials. Prog Neurobiol. 2011 Dec;95(4):579-93. Epub 2010 Dec 2.

Kadir A, Marutle A, Gonzalez D, Schöll M, Almkvist O, Mousavi M, Moustafiz T, Darreh-Shori T, Nennesmo I, Nordberg A. Positron emission tomography imaging and clinical progression in relation to pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease. Brain. 2011 Jan;134(Pt 1):301-17. Epub 2010 Dec 13

Kwak YD, Marutle A, Dantuma E, Merchant S, Bushnev S, Sugaya K. Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation. Eur J Pharmacol 2011 Jan 10;650(1):18-27. Epub 2010 Sep 29

1998- 2010

List of scientific publications