David Lane Group

The protein p53, widely known as the guardian of the genome, was discovered by Prof. Sir David Lane in 1979 and has over the years been recognized as a tumor suppressor gene mutated in more than half of all malignant tumors occurring in adults. Apart from its role as a tumor suppressor, p53 has been shown to be involved in numerous regulatory cell functions. Research in our lab is focused on understanding the many facets of p53 biology in malignant and normal cells. We employ cutting edge technology such as mass spectometry, advanced microscopy, multi-color flow cytometry and imaging cytometry to this end and strive to translate our findings to the clinic.

 

Group Members

Professor

David Lane

Organizational unit: David Lane group
E-mail: david.lane@ki.se

Cecilia BosdotterLaboratory technician
Nicolas FritzSenior research specialist
Katrine IngelshedPhD student, Graduate Student
Michael LandrehAssistant professor
David LaneProfessor
Nikita LoikPostdoc
Harsha MadapuraPostdoc
Tanzina MollickPhD student, Graduate Student
Saket Milind NigamPostdoc
Andrés Pastor FernándezLaboratory technician
Saikiran SedimbiSenior research specialist
Chandra VermaAssociated

 

Publications

Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.
Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D
Cancer Res. 2017 Aug;77(16):4342-4354

Exploiting the p53 Pathway for Therapy.
Cheok C, Lane D
Cold Spring Harb Perspect Med 2017 Mar;7(3):

Cancer. p53, guardian of the genome.
Lane D
Nature 1992 Jul;358(6381):15-6

T antigen is bound to a host protein in SV40-transformed cells.
Lane D, Crawford L
Nature 1979 Mar;278(5701):261-3

 

Further publications

All scientific publications from David Lane

 

Funding

The Swedish Research Council (Vetenskapsrådet)

 

Contact

David Lane Laboratory at Sci Life
Tometebodavägen 23A (Gamma building, 5th floor),
Solna 17165
P53 Laboratory in Singapore
The p53 lab in singapore is focusing on the development of new therapies, new diagnostics and new discoveries in the p53 pathway.
More information on the website
Tumour Biology