Cardiovascular Eicosanoid Research

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During the inflammation which promotes atherosclerosis, a group of important mediators, called leukotrienes, is formed from lipids. The blockade of leukotriene-induced effects could lead to novel concepts of treatment against cardiovascular diseases.


Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.
Bäck M, Bu D, Bränström R, Sheikine Y, Yan Z, Hansson G
Proc. Natl. Acad. Sci. U.S.A. 2005 Nov;102(48):17501-6

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus.
Houard X, Ollivier V, Louedec L, Michel J, Bäck M
FASEB J. 2009 May;23(5):1376-83

Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Foudi N, Norel X, Rienzo M, Louedec L, Brink C, Michel J, et al
Am. J. Physiol. Heart Circ. Physiol. 2009 Nov;297(5):H1882-8

Leukotriene receptor antagonism and the prevention of extracellular matrix degradation during atherosclerosis and in-stent stenosis.
Hlawaty H, Jacob M, Louedec L, Letourneur D, Brink C, Michel J, et al
Arterioscler. Thromb. Vasc. Biol. 2009 Apr;29(4):518-24

5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation.
Bäck M, Sultan A, Ovchinnikova O, Hansson G
Circ. Res. 2007 Apr;100(7):946-9



Magnus Bäck

Phone: 08-517 764 20

Magnus Bäck