Selected publications from Center for Hematology and Regenerative Medicine (HERM)

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.
Dimitriou M, Woll P, Mortera-Blanco T, Karimi M, Wedge D, Doolittle H, et al
Oncotarget 2016 Nov;7(45):72685-72698

SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.
Malcovati L, Karimi M, Papaemmanuil E, Ambaglio I, Jädersten M, Jansson M, et al
Blood 2015 Jul;126(2):233-41

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes T, et al
Immunity 2015 Mar;42(3):443-56

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.
Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes T, Chiang S, et al
Blood 2017 Apr;129(16):2266-2279

Giustacchini A*, Thongjuea S*, Barkas N, Woll PS, Sopp P, Norfo R, Rodriguez Meira A, Booth C, Ashley N, Jamieson L, Anderson K, Segerstolpe A, Qian H, Stromberg U, Mustjoki S, Sandberg R, Jacobsen SE*, Mead AJ*. Single-cell transcriptomics uncovers distinct and clinically predictive molecular signatures of stem cell in chronic myeloid leukemia. Nature Medicine, In press (*Equal contribution).

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.
Luis T, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll P, et al
Nat. Immunol. 2016 Dec;17(12):1424-1435

Changes in spatial tuning of the pattern electroretinogram with age.
Porciatti V, Falsini B, Fadda A, Neroni M, Minnella A, Scalia G
Metab Pediatr Syst Ophthalmol (1985) 1989 ;12(1-3):74-5

Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma.
Usmani S, Weiss B, Plesner T, Bahlis N, Belch A, Lonial S, et al
Blood 2016 Jul;128(1):37-44