Emil Hansson group
Heart disease is a leading cause of mortality in the industrialized world. Improved management of risk factors and treatment of acute phase of the injury has resulted in more patients surviving the acute phase of a myocardial infarction, but these patients often suffer from compromised heart function that can lead to chronic heart failure.
Heart failure is a severe condition characterized by complex tissue remodeling involving cardiomyocyte death, dysregulated metabolism, and interstitial fibrosis. There is no curative treatment for heart failure, and the more severe forms of heart failure have a worse prognosis than many forms of cancer. Therefore, development of novel modes of therapy is warranted.
Our research group is interested in the molecular and cellular mechanisms controlling the development, homeostasis, and response to injury in the mammalian heart. We are particularly interested in the cellular heterogeneity of the heart and how the different cell types are assembled during embryogenesis to form the heart, and how different cells in the heart react to cardiac injury. By experimentally addressing these issues in both whole animal experiments and cell culture models, we hope to further our knowledge on clinically relevant problems such as the pathogenesis of fibrosis in the cardiovascular system and the possibility to augment the regeneration of lost cardiomyocytes to improve cardiac function.
Emil Hansson, Group leader, Assistant professor
Stefanos Leptidis, Postdoc
Giorgia Palano, PhD student
Alessandra Rigamonti, Postdoc
Nelly Rahkonen, Postdoc
Aldo Moggio, Postdoc