Twin Offspring Study in Sweden - TOSS

The main focus of this study is to examine if patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men.

Project description

Studies that have examined genetic and environmental contributions to measures of family relationships and to associations between family relationships and mental health have found two different patterns of results for adults and children. For children, genetic factors explain most of the covariance between parent-child relationships and child adjustment, while in adults nonshared environmental factors account for most of the covariance between marital relationships and adult adjustment. These different patterns of findings suggest that different mechanisms are involved in linking pertinent family relationships to adjustment in children and adults.
This project extends the Twin Moms Project and includes a sample of twin fathers and their families (N=320 twin pairs and their families) and to collect an addition 250 pairs of twin mothers for a sample of 900 twin parents and their families (total N about 3,000 individuals). This expanded sample enables us to examine whether patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men. We also utilize the full twin families design in an effort to distinguish between different types of genotype-environment correlation for the associations between family relationships and child adjustment. As such, this information will enable us to understand better how and why relationships within the family affect the mental health of family members.
We have collected data on family relationships, including parent-child, marital and siblings, on adult and child mental health, and on the individual attributes of family members. Twin parents, their partner and the target child will participate through questionnaires and an interview, using a multi-agent, multi-method strategy.

Project leader

Professor

Paul Lichtenstein

Phone: +46-(0)8-524 874 24
Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Paul.Lichtenstein@ki.se

Partners

Jenae Neiderhiser Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington
David Reiss Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington
Nancy Pedersen MEB
Erica Spotts Center for Family Research, Department of Psychiatry and Behavioral Sciences, George Washington University, Washington
Elias Eriksson Göteborg University
Main financing: National Institute of Mental Health, Riksbankens Jubileumsfond

References

  1. Horwitz BN, Reynolds C, Walum H, Ganiban J, Spotts EL, Reiss D, Lichenstein P, Neiderhiser JM. Understanding The Role of Mate Selection Processes in Couples’ Pair-Bonding Behavior. Behavior Genet In press.   
  2. Parental knowledge is an environmental influence on adolescent externalizing.
    Marceau K, Narusyte J, Lichtenstein P, Ganiban J, Spotts E, Reiss D, et al
    J Child Psychol Psychiatry 2015 Feb;56(2):130-7
  3. Parental criticism is an environmental influence on adolescent somatic symptoms.
    Horwitz B, Marceau K, Narusyte J, Ganiban J, Spotts E, Reiss D, et al
    J Fam Psychol 2015 Apr;29(2):283-9
  4. The Intergenerational Transmission of Anxiety: A Children-of-Twins Study.
    Eley T, McAdams T, Rijsdijk F, Lichtenstein P, Narusyte J, Reiss D, et al
    Am J Psychiatry 2015 Jul;172(7):630-7
  5. Accounting for genetic and environmental confounds in associations between parent and child characteristics: a systematic review of children-of-twins studies.
    McAdams T, Neiderhiser J, Rijsdijk F, Narusyte J, Lichtenstein P, Eley T
    Psychol Bull 2014 Jul;140(4):1138-73
  6. The observed association between maternal anxiety and adolescent asthma: children of twin design suggest familial effects.
    Havland I, Lundholm C, Lichtenstein P, Neiderhiser J, Ganiban J, Spotts E, et al
    PLoS ONE 2013 ;8(6):e66040
  7. Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.
    Walum H, Lichtenstein P, Neiderhiser J, Reiss D, Ganiban J, Spotts E, et al
    Biol. Psychiatry 2012 Mar;71(5):419-26
  8. Genetic and environmental influences on the association between pubertal maturation and internalizing symptoms.
    Marceau K, Neiderhiser J, Lichtenstein P, Reiss D
    J Youth Adolesc 2012 Sep;41(9):1111-26
  9. A genetically informed study of associations between family functioning and child psychosocial adjustment.
    Schermerhorn A, D'Onofrio B, Turkheimer E, Ganiban J, Spotts E, Lichtenstein P, et al
    Dev Psychol 2011 May;47(3):707-25
  10. Parental criticism and externalizing behavior problems in adolescents: the role of environment and genotype-environment correlation.
    Narusyte J, Neiderhiser J, Andershed A, D'Onofrio B, Reiss D, Spotts E, et al
    J Abnorm Psychol 2011 May;120(2):365-76
  11. The role of aggressive personality and family relationships in explaining family conflict.
    Horwitz B, Ganiban J, Spotts E, Lichtenstein P, Reiss D, Neiderhiser J
    J Fam Psychol 2011 Apr;25(2):174-83
  12. Genetic and environmental influences on global family conflict.
    Horwitz B, Neiderhiser J, Ganiban J, Spotts E, Lichtenstein P, Reiss D
    J Fam Psychol 2010 Apr;24(2):217-20
  13. A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement.
    D'Onofrio B, Singh A, Iliadou A, Lambe M, Hultman C, Neiderhiser J, et al
    Child Dev ;81(1):80-100
  14. Temperament and character associated with depressive symptoms in women: analysis of two genetically informative samples.
    Yuh J, Neiderhiser J, Lichtenstein P, Hansson K, Cederblad M, Elthammer O, et al
    J Clin Psychol 2009 Sep;65(9):906-24
  15. Understanding the role of personality in explaining associations between marital quality and parenting.
    Ganiban J, Ulbricht J, Spotts E, Lichtenstein P, Reiss D, Hansson K, et al
    J Fam Psychol 2009 Oct;23(5):646-60
  16. The role of temperament and social support in depressive symptoms: a twin study of mid-aged women.
    Yuh J, Neiderhiser J, Spotts E, Pedersen N, Lichtenstein P, Hansson K, et al
    J Affect Disord 2008 Feb;106(1-2):99-105
  17. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans.
    Walum H, Westberg L, Henningsson S, Neiderhiser J, Reiss D, Igl W, et al
    Proc. Natl. Acad. Sci. U.S.A. 2008 Sep;105(37):14153-6
  18. Neiderhiser J, Lichtenstein P. The Twin and Offspring Study in Sweden: Advancing our understanding of genotype-environment interplay by studying twins and their families. Acta Psychologia Sinica 2008;4:1116-23.   
  19. Testing different types of genotype-environment correlation: an extended children-of-twins model.
    Narusyte J, Neiderhiser J, D'Onofrio B, Reiss D, Spotts E, Ganiban J, et al
    Dev Psychol 2008 Nov;44(6):1591-603
  20. Individual resiliency factors from a genetic perspective: results from a twin study.
    Hansson K, Cederblad M, Lichtenstein P, Reiss D, Pedersen N, Neiderhiser J, et al
    Fam Process 2008 Dec;47(4):537-51
  21. Depression and internally directed aggression: genetic and environmental contributions.
    Haddad S, Reiss D, Spotts E, Ganiban J, Lichtenstein P, Neiderhiser J
    J Am Psychoanal Assoc 2008 Jun;56(2):515-50
  22. Father-adolescent relationships and the role of genotype-environment correlation.
    Neiderhiser J, Reiss D, Lichtenstein P, Spotts E, Ganiban J
    J Fam Psychol 2007 Dec;21(4):560-71
  23. Aggression as a mediator of genetic contributions to the association between negative parent-child relationships and adolescent antisocial behavior.
    Narusyte J, Andershed A, Neiderhiser J, Lichtenstein P
    Eur Child Adolesc Psychiatry 2007 Mar;16(2):128-37
  24. Can genetic factors explain the spillover of warmth and negativity across family relationships?
    Ganiban J, Spotts E, Lichtenstein P, Khera G, Reiss D, Neiderhiser J
    Twin Res Hum Genet 2007 Apr;10(2):299-313
  25. Genetic effects on women's positive mental health: do marital relationships and social support matter?
    Spotts E, Pederson N, Neiderhiser J, Reiss D, Lichtenstein P, Hansson K, et al
    J Fam Psychol 2005 Sep;19(3):339-49
  26. Spotts EL, Lichtenstein P, Pedersen N, Neiderhiser JM, Hansson K, Cederblad M, Reiss D. Personality and marital satisfaction: A behavioural genetic analysis. Eur J Personality 2005;19:205-27.   
  27. Genetic and environmental influences on marital relationships.
    Spotts E, Neiderhiser J, Towers H, Hansson K, Lichtenstein P, Cederblad M, et al
    J Fam Psychol 2004 Mar;18(1):107-19
  28. Accounting for depressive symptoms in women: a twin study of associations with interpersonal relationships.
    Spotts E, Neiderhiser J, Ganiban J, Reiss D, Lichtenstein P, Hansson K, et al
    J Affect Disord 2004 Oct;82(1):101-11
  29. Genetic and environmental influences on mothering of adolescents: a comparison of two samples.
    Neiderhiser J, Reiss D, Pedersen N, Lichtenstein P, Spotts E, Hansson K, et al
    Dev Psychol 2004 May;40(3):335-51
  30. Remembered parental bonding in adult twins: genetic and environmental influences.
    Lichtenstein P, Ganiban J, Neiderhiser J, Pedersen N, Hansson K, Cederblad M, et al
    Behav. Genet. 2003 Jul;33(4):397-408
  31. Genetic probes of three theories of maternal adjustment: I. Recent evidence and a model.
    Reiss D, Pedersen N, Cederblad M, Lichtenstein P, Hansson K, Neiderhiser J, et al
    Fam Process 2001 ;40(3):247-59
  32. Genetic probes of three theories of maternal adjustment: II. Genetic and environmental influences.
    Reiss D, Cederblad M, Pedersen N, Lichtenstein P, Elthammar O, Neiderhiser J, et al
    Fam Process 2001 ;40(3):261-72
GeneticsTwin research