Radiation dose response for second primary cancers of the stomach, esophagus, and pancreas: a study of cancer survivors
Numerous studies have identified the bone marrow, thyroid gland and female premenopausal breast as the tissues most susceptible to ionization radiation in the human body. Less is known about the susceptibility of the organs of the gastrointestinal tract.
Detailed information on tumour characteristics and therapy has been gathered from the case records and the abstraction was finalized during the spring of 2007. In parallel, tissue has been collected from first and second cancers. Polymorphisms in mainly DNA repaired genes will be analyzed and related to risk of a second cancer.
A number of studies are focusing on radiation-induced stomach, oesophagus and pancreas cancer are ongoing. All of them are nested case-control studies and different groups have taken responsibility for different outcomes. A number of papers have already been published as listed below.
Project leader for the Swedish part: Per Hall
Project period: 2002-ongoing
Main financing: National Cancer Institute (NCI)
Ruth Kleinerman, Dr., Radiation and Epidemiology Branch, National Cancer Institute, USA
Lindsay Morton, Dr., Radiation and Epidemiology Branch, National Cancer Institute, USA
Second cancers among 40,576 testicular cancer patients: focus on long-term survivors.
J. Natl. Cancer Inst. 2005 Sep;97(18):1354-65
Acute myeloid leukemia following Hodgkin lymphoma: a population-based study of 35,511 patients.
J. Natl. Cancer Inst. 2006 Feb;98(3):215-8
Suicide after breast cancer: an international population-based study of 723,810 women.
J. Natl. Cancer Inst. 2006 Oct;98(19):1416-9
Leukemia following breast cancer: an international population-based study of 376,825 women.
Breast Cancer Res. Treat. 2007 Nov;105(3):359-68
Risk of second non-hematological malignancies among 376,825 breast cancer survivors.
Breast Cancer Res. Treat. 2007 Dec;106(3):439-51
Noncancer causes of death in survivors of testicular cancer.
J. Natl. Cancer Inst. 2007 Apr;99(7):533-44
Long-term solid cancer risk among 5-year survivors of Hodgkin's lymphoma.
J. Clin. Oncol. 2007 Apr;25(12):1489-97
Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk.
J. Natl. Cancer Inst. 2007 Nov;99(21):1634-43
Second cancers after squamous cell carcinoma and adenocarcinoma of the cervix.
J. Clin. Oncol. 2009 Feb;27(6):967-73
Risk of treatment-related esophageal cancer among breast cancer survivors.
Ann. Oncol. 2012 Dec;23(12):3081-91
Radiation dose and subsequent risk for stomach cancer in long-term survivors of cervical cancer.
Int. J. Radiat. Oncol. Biol. Phys. 2013 Aug;86(5):922-9
Stomach cancer risk after treatment for hodgkin lymphoma.
J. Clin. Oncol. 2013 Sep;31(27):3369-77