Lifestyle and genetic factors in the progression of prostate cancer

The goal of this study was to investigate if common genetic variants are important for prostate cancer progression.

Project leader

Professor/senior physician

Henrik Grönberg

Organizational unit: Department of Medical Epidemiology and Biostatistics (MEB), C8
E-mail: Henrik.Gronberg@ki.se

Project description

To investigate if common genetic variants are important for prostate cancer progression, we will use the unique study population in CAPS and a large cohort of 8,000 men with localized prostate cancer.

The main outcomes in these studies are progression or death due to prostate cancer and not prostate cancer risk. We will use the genotype data available from the CAPS studies. In addition, we are planning to conduct a genome wide SNP scan in patients from the cohort of localized prostate cancer. The design of this study is a series of nested case-control studies within a cohort of approximately 8,000 men diagnosed with localized prostate cancer.

In a three-stage approach, we will commence with studying over 300,000 SNPs among 10% of the cohort. The approximately 16,000 statistically significant SNPs will then be studied in an additional sub-cohort to replicate significant associations from the exploratory stage. A further reduced number of SNPs will be studied in the remainder of the cohort. The lifestyle factors will be assessed through web-based questionnaires with questions regarding diet and physical activity.

Prostate cancer