Current research

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As our name suggests, the main focus for our research are epidemiology and biostatistics. Within these two areas of research, our researchers study a wide range of medical issues and biostatistical analysis and methodology. If you want to read more, below you find a brief description of a selection of current areas and research projects.

There are many more ongoing projects in the department, and if you are interested in a particular area, you can always contact our researchers to find out more. Please note that some projects can be found in several areas of research and that information about completed projects can be found on a separate page. Some projects may have a Swedish only web page.

Ageing

Nancy Pedersen SATSA - The Swedish Adoption/Twin Study of Aging A study on what factors contribute to a good old age.
Sara Hägg Molecular epidemiology studies of aging and aging-related diseases A research description of several projects using biomarker data to understand the process of aging

Biostatistics

The MEB Biostatistics Group is involved in a wide variety of research projects, including population-based cohort and case-control studies, twin and family studies, survival analyses, predictive modeling, molecular and genetic epidemiology, and bioinformatics and high-throughput data analyses.

Cancer epidemiology

Hans-Olov Adami Etiology of Carcinoma of the Cervix The study aims to improve the prevention of cervical cancer.
" European Polyp Surveillance Trials (EPoS) The study is based on the hypothesis that costs and adverse effects can be minimized without jeopardizing the benefits of surveillance to detect and remove precursor lesions.
" Risk of colorectal cancer following adenoma removal – SAR. This study aims to quantify the excess risk of colorectal cancer, if any, following adenoma removal.
" SPCG-4: Radical prostatectomy versus watchful waiting in early prostate cancer: Scandinavian Prostate Cancer Group Study Number 4 A study on the best strategy for curative treatment for prostate cancer.
" SPCG-17 Prostate Cancer Active Surveillance Threshold Study (PCASTS): A multicenter randomized trial The aim of this trial is to test the non-inferiority of an active surveillance protocol with a high compared with one with a low threshold for active therapeutic intervention.
Hans-Olov Adami/Kamila Czene The Nordic Twin Study of Cancer (NorTwinCan) A twin study on the heritability and familial risk of certain cancers.
Hans-Olov Adami/Weimin Ye Gene-environment-EBV interactions in the etiology of nasopharyngeal carcinoma A study of risk factors for nasopharyngeal carcinoma conducted in China.
Lisen Arnheim Dahlström ACCES: Advancing Cervical Cancer Eradication Strategies A study of optimized cervical cancer prevention.
" Women's health A study evaluating the impact of HPV vaccine in the population.
Katarina Bälter Lifestyle factors and prostate cancer A project to study the importance of modifiable lifestyle factors for prevention of prostate cancer as well as for survival after a prostate cancer diagnosis.
Kamila Czene Identification of women at increased risk of fatal breast cancer A study on what women have an increased risk of fatal breast cancer.
Fang Fang Psychological Stress and its Related Health Outcomes A research description of several projects on the health impact of psychological stress with a focus on bereavement and cancer.
Henrik Grönberg Cancer of the Prostate in Sweden (CAPS) A study to get data on markers of prostate cancer progression.
" Clinseq ClinSeq develops infrastructure for genomic profiling in cancer research.
" Lifestyle and genetic factors in the progression of prostate cancer A study on common genetic variants and their importance for prostate cancer progression.
" Linneus centre CRisP for prevention of breast and prostate cancer A centre on individualized cancer risk prediction and prevention to decrease mortality.
" Identification and confirmation of new genetic variants that explain the genetic susceptibility of prostate cancer A study of 120 families with hereditary prostate cancer.
Per Hall PESTO: Radiation dose response for second primary cancers of the stomach, esophagus, and pancreas.  A study of second primary cancer in cancer survivors.
". RACE: Radiotherapy for Breast Cancer and Subsequent Risk of Cardio-Vascular Events A study on late adverse health effects in cancer survivors.
" The COGS project: The Collaborative Oncological Gene-environment Study A European collaboration on breast, ovarian and prostate cancer. 
" The Karma project The study aims to reduce the mortality and incidence of breast cancer by focusing on prevention.
Mats Lambe AMORIScancer: Metabolic Profiles and Cancer A study on the role of metabolic markers in cancer development.
" Breast and prostate cancer A study on aspects of co-morbidity, drug use and long term survival in patients with advanced disease.
" Gender differences in cancer survival: stage at diagnosis, treatment and comorbidity A study on gender differences in cancer survival.
" Quality of life following a breast cancer diagnosis A study of work-related quality of life after a breast cancer diagnosis.
" PcBaseSweden - a platform for prostate cancer research A study to improve the understanding of aspects of prostate cancer.
" Pregnancy-associated breast cancer (PABC) A study of breast cancer during pregnancy or within two years after delivery.
" Social and work-related consequences after a cancer diagnosis A study on social and work life consequences in patients of working age.
" Stress and cancer development and prognosis A study on of traumatic life events and association with cancer risk and survival.
Olof Nyrén The Swedish National March Cohort (NMC) A cohort of 40 000 men and women with questionnaire data. 
Pär Sparén ACCES: Advancing Cervical Cancer Eradication Strategies A study on the implementation and evaluation of new preventive strategies.
Elisabete Weiderpass Vainio Infectious diseases and cancer in Uganda Studies focusing on cancer epidemiology in Kampala, Uganda.
" Nordic Occupational Cancer Study (NOCCA) A study with 45 years of cancer incidence data by occupational category for the Nordic populations.
" Pregnancy estrogens, diet and possible breast cancer risk A study of breast cancer, estrogen levels and diet.
" Prognosis for ovarian cancer A study of the effect of hormone-related factors for ovarian cancer on tumour characteristics.
" Women's lifestyle and health (WLH) A study focusing on cancer, cardiovascular diseases and some chronic diseases.
Weimin Ye The microbiome and risk of cancer in the stomach A study focusing on H. pylori genotypic variation as a predictor of carcinogenicity.

Climate epidemiology

Katarina Bälter Sustainable lifestyle We are studying the link between food habits, intake of nutrients, greenhouse gas emission and health related markers.

Cohort studies

Nancy Pedersen LifeGene The projects aim to provide new knowledge about our most common diseases and health problems.
Elisabete Weiderpass Vainio Women's Lifestyle and Health A study focusing on cancer, cardiovascular diseases and some chronic diseases.

Genetics/genomics

Henrik Grönberg Clinseq ClinSeq develops infrastructure for genomic profiling in cancer research.
Christina Hultman The BROAD study A population-based case-control genetic study of schizophrenia
Christina Hultman / Mikael Landén The Stanley study A study about genetic and environmental causes behind bipolar syndrome. (In Swedish)
Mikael Landén ANGI A genetic study about Anorexia Nervosa. (In Swedish)
Patrick Sullivan GAPS A national genetic epidemiology consortium

Gastroenterology

Jonas Ludvigsson IBD Alliance The IBD Alliance at the Karolinska Institutet/Hospital is a network of physicians and researchers (physicians/non-physicians) interested in IBD with the aim to promote the interaction between clinical care and research.
-"- Scandinavian CANcer-in-Inflammatory Bowel Disease study (SCAN-IBD) This study aims to examine the risk of cancer and mortality in IBD in a cohort of patients from three Nordic countries. Also to examine risk factors for colorectal cancer in patients with IBD.

Infections

Lisen Arnheim Dahlström ACCES: Advancing Cervical Cancer Eradication Strategies A study of optimized cervical cancer prevention.
" ADVANCE: Accelerated Development of VAcciNe outcome research Collaboration in Europe A study aimed to build an integrated and sustainable framework for continuous vaccine effect monitoring.
" Determining country specific vaccine decision-making frameworks A study on optimal vaccine decision-making processes and communication for prevention of infectious diseases in the Nordic countries.
" Susceptibility to herpes zoster (shingles) Who is susceptible to herpes zoster (shingles), how common are complications after disease and what complications are most common?
" Who is vaccinated with the zoster vaccine? A population-based study in Stockholm county A study to describe and characterise individuals who have been vaccinated.
" Women's health study A study aiming at evaluating the impact of HPV vaccine in the population.
Katarina Bälter LIME A population-based cohort study on lifestyle factors (physical activity, diet, supplements, sleep) and susceptibility to infections.

Molecular epidemiology

Sara Hägg Molecular epidemiology studies of aging and aging-related diseases A research description of several projects using biomarker data to understand the process of aging
Weimin Ye The microbiome and risk of cancer in the stomach A study focusing on H. pylori genotypic variation as a predictor of carcinogenicity.

Neurodegenerative diseases

Nancy Pedersen A Twin Study of Environmental Factors in Parkinson's Disease A study assessing the importance of environmental factors for PD in Swedish twins.
" Dementia in Swedish Twins - HARMONY Molecular genetic studies to identify a number of mutations and markers associated with early age of onset Alzheimer's disease.
Weimin Ye/Fang Fang Amyotrophic Lateral Sclerosis (ALS) A study on the gene-environment interactions on ALS risk and prognosis.

Nutrition

Katarina Bälter The Active-Q Physical Activity Questionnaires Questionnaires aim at assessing physical activity and inactivity among all ages.

Psychiatric epidemiology

Cynthia Bulik CEDI - Centre for Eating Disorders Innovation A centre focused on advancing our understanding of eating disorders.
Fang Fang  Psychological Stress and its Related Health Outcomes A study of the health impact of psychological stress with a focus on bereavement and cancer.
Christina Hultman  Academic achievement in adolescence as risk factors for schizophrenia and bipolar disorder A study examining school performance as risk factors for schizophrenia, bipolar disorder and other psychoses.
" The BROAD study A population-based case-control genetic study of schizophrenia
" The EGOs study A study of genetic and environmental factors in obsessive-compulsive disorder, Tourette syndrome and tics.
" Psychotic symptoms in the general population A study using the Internet as a medium for collecting epidemiological large-scale psychology- and psychiatry-related data.
" The Swedish Tsunami Cohort A study on risk factors of long-term psychiatric and somatic morbidity of Swedish survivors.
" Schizophrenia: Early etiological factors, prognosis and family burden A study  of the possible etiological role of prenatal underdevelopment around birth in schizophrenia.
Christina Hultman/Mikael Landén The Stanley study A study about genetic and environmental causes behind bipolar syndrome (in Swedish),
Mikael Landén ANGI A genetic study about Anorexia Nervosa. (In Swedish)
" PREFECT A study about electroconvulsive therapy. (In Swedish)
Patrick Sullivan KI Psychiatric Genomics Institute  
Elisabete Weiderpass Vainio Women's lifestyle and health WLH is a large study focusing on health outcomes such as cancer, cardiovascular diseases and some chronic diseases.

Twin studies

Hans-Olov Adami/Kamila Czene The Nordic Twin Study of Cancer (NorTwinCan) A twin study on the heritability and familial risk of certain cancers.
Paul Lichtenstein Twin Study of Child and Adolescent Development - TCHAD A study addressing the interplay between genes and environments, comorbidity, and the development into adult psychopathology.
" Twin Offspring Study in Sweden - TOSS This study examines if patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men.
" The Child and Adolescent Twin Study in Sweden (CATSS) This study investigates how both genetic and environmental effects influence health and behavior in children and adolescents.
" Causes and consequences of criminality and psychiatric disorders A study of the mechanisms behind intergenerational transmissions of psychiatric problems.
Nancy Pedersen A Twin Study of Environmental Factors in Parkinson's Disease A study assessing the importance of environmental factors for PD in a sample of Swedish twins.
" HARMONY A study on dementia in twins.
" SATSA - The Swedish Adoption/Twin Study of Aging As the population ages, the vital question becomes: how to have a good old age.
" TWINGENE and GenomeEUtwin A study on the Importance of quantitative trait loci and environmental factors for cardiovascular disease.

Women's and children's health

Catarina Almqvist Malmros SIMSAM: MEB family design Studies on risks and consequences of common childhood disorders.
Elisabete Weiderpass Vainio Women's lifestyle and health WLH is a large study focusing on health outcomes such as cancer, cardiovascular diseases and some chronic diseases.
AgeingBiostatisticsCancer and OncologyEpidemiologyGastroenterology and HepatologyGeneticsNeurodegenerative diseasesNutritionPsychiatryTwin research