At IMM a wide range of diseases, mainly endemic diseases are studied in terms of aetiology and factors affecting prognosis after diagnosis.
Projects in this area
Allergy, hyperreactivity and skin irritants
Allergies are among the most common chronic conditions worldwide and include a number of conditions caused by hypersensitivity of the immune system to something in the environment. Common allergens include pollen, food and various metals. At IMM research related to various skin exposures of workers, consumers and children and the risk in developing skin allergy and dermatitis is performed. Other areas include risk and protective factors for the development of allergies in children as well as mechanisms related to immune reactions.
Cancer is one of the world´s leading causes of morbidity and death. For great majority of the cancers, environmental factors play a critical role. These factors include life-style and behavioral factors as well as chemicals and contaminants in the environment. Many cancers can be prevented by avoiding exposure to risk factors and living a healthy life-style. Cancer research at IMM is broad and spans from basic experimental research to epidemiology.
- Pooled analysis of European case-control studies on lung cancer - SYNERGY
- Occupational exposure to chemicals and breast cancer
- Genetic and epigenetics of metals
- Chimney sweeping and risk of cancer
Cardiovascular disease is one of the world´s leading causes of morbidity and death. IMM research covers a broad span in the cardiovascular area and uses both experimental methods such as cell models and epidemiological methods such as cohort studies to increase knowledge about its aetiology. National high quality registers are frequently used in the research projects.
- Inflammatory markers and coronary heart disease
- SHEEP - Stockholm Heart Epidemiology Program
- SHEEP - The Stockholm Heart Epidemiology Program
- The 60-year old cohort - An epidemiological cohort study of men and women, born 1937 and 1938 in Stockholm County
- WOLF- Work, Lipids and FibrinogenCommon mental disorders
Common mental disorders
Common mental disorders (CMD:s) are the leading cause of sick-leave spells in Sweden, resulting in suffering for the individual and financial costs for the employer as well as for society at large. It is also very frequent in several other OECD countries.
- Return to work/improving work ability among employees with stress or common mental disorders
- A gender sensitive evaluation of an individual and workplace-based intervention for employees with stress or common mental disorders
Diabetes and other metabolic diseases
The worldwide prevalence of metabolic diseases including diabetes is increasing. Also obesity, closely linked to metabolic disease, is becoming increasingly frequent both in adults and children. This is worrisome because these diseases may impair health. At IMM several research projects aim at increasing knowledge about the causes and consequences of metabolic disease and obesity.
- ESTRID - Epidemiological study of risk factors for LADA and type 2 diabetes
- Autoimmune Bullous Diseases in Sweden
Muskulo skeletar diseases
Musculoskeletal disease, in particular long-lasting back- or neck pain is very frequent in the general population. IMM research focus both on aetiology and treatment of such diseases. Another research area is injuries related to sports and work related MSD.
- EIMS - an epidemiological investigation of risk factors for Multiple Sclerosis
- MUSIC - The Musculoskeletal Intervention Center
- GEMS - Genes and Environment in Multiple Sclerosis
- The IMSE studies - clinical phase 4 studies for two immunomodulatory drugs for multiple sclerosis
- Recurrent and persistent low back pain
- Preferences for physical activity in managing low back pain
Respiratory diseases are diseases that affect the air passages, the bronchi and the lungs, and include asthma and chronic obstructive pulmonary disease (COPD). At IMM, research is performed to investigate risk- and protective factors for asthma among children. Other areas include COPD and mechanisms related to how exposure to environmental agents affect immune cells, as well as the development of new models for studying asthma, respiratory inflammation and lung effects of air pollutants.
- Th17-associated cytokines and host defense in smokers
- The IL-36 family of cytokines in chronic obstructive pulmonary disease
Rheumatoid artrit and chronic inflammation
Inflammation plays a key role in a number of different chronic diseases such as rheumatoid arthritis, atherosclerosis and asthma. At IMM, experimental laboratory research is performed to unravel the biology behind the initiation and the progression of chronic inflammatory processes. Epidemiological research is also performed to increase knowledge about causes of different inflammatory diseases including rheumatoid arthritis.