Computer modeling of toxicokinetics and cellular signaling pathways

Course dates

The course is given every second or third year. The last course was on May 13-17, 2013. Next course dates will be announced here later.

Course organiser

The course is organised by the Advanced International Training Programme in Health Risk Assessment at IMM in collaboration with the Doctoral programme Environmental Factors and Health at Karolinska Institutet, course number 2208.

Course credits

The course corresponds to 1.5 ECTS credits.

Learning outcomes

After the course, the students should understand and be able to apply basic principles in toxicokinetic (TK), including physiologically based pharmacokinetic (PBPK) and toxicodynamic (TD) modeling. Further, they should be aware of modeling techniques for quantitative investigation of how biological systems respond to perturbations at the cellular level and of the biological circuits that control these responses.


The course will cover the following major topics: - Basic TK, PBPK and TD concepts. - Issues in model development and validation including sensitivity analysis, uncertainty and variability, Monte Carlo simulation. - Approaches to modeling biological response pathways including homeostasis, adaptation, threshold response, binary cell fate decisions, and irreversible differentiation. - Applications of TK, PBPK, TD and biological systems modeling in toxicological risk assessment.

Teaching and learning activities

This one-week full time course consists of daily lectures and daily computer exercises. Dr. Melvin Andersen from The Hamner Institutes of Health Sciences, Research Triangle Park, North Carolina, USA is one of the main teachers at the course.

Course programme

The course programme for the previous course on May 13-17, 2013 is available here.

The course is intended for

PhD students and post docs as well as participants from authorities and industry.

Course fee

There is no course fee for PhD students. The fee for participants from academia (except PhD students), from authorities and from industry will be announced later. Course fee includes course material, coffee breaks and a get together reception. Payment of course fee can only be accepted from the participant’s employer, not from individuals.

The participants must cover their costs for travel and accommodation.

Course application

Information on application procedure to the next course will be available later.

Course leader

Gunnar Johanson, Institute of Environmental Medicine, Karolinska Institutet.


Senior lecturer

Johanna Zilliacus

Phone: +46-(0)8-524 835 44
Organizational unit: Biochemical toxicology

Health risk assessment