Olof Rådmark

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: FASEB JOURNAL. 2021;35(2):e21193
Modulation of microRNA processing by 5-lipoxygenase
Uebbing S; Kreiss M; Scholl F; Haefner A-K; Sueruen D; Garscha U; Werz O; Basavarajappa D; Samuelsson B; Radmark O; Suess B; Steinhilber D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(15):8573-8583
Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells
Basavarajappa D; Uebbing S; Kreiss M; Lukic A; Suess B; Steinhilber D; Samuelsson B; Radmark O
Article: CANCER LETTERS. 2019;444:1-8
Exosomes and cells from lung cancer pleural exudates transform LTC4 to LTD4, promoting cell migration and survival via CysLT1
Lukic A; Wahlund CJE; Gomez C; Brodin D; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: FASEB JOURNAL. 2017;31(10):4370-4381
GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures
Lukic A; Larssen P; Fauland A; Samuelsson B; Wheelock CE; Gabrielsson S; Radmark O
Article: LEUKEMIA & LYMPHOMA. 2017;58(8):1903-1913
Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia
Yektaei-Karin E; Zovko A; Nilsson A; Nasman-Glaser B; Kanter L; Radmark O; Wallvik J; Ekblom M; Dolinska M; Qian H; Stenke L
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(8):2099-2111
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Mittal M; Hasan M; Balagunaseelan N; Fauland A; Wheelock C; Radmark O; Haeggstrom JZ; Rinaldo-Matthis A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(8):3167-3176
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males
Pace S; Pergola C; Dehm F; Rossi A; Gerstmeier J; Troisi F; Pein H; Schaible AM; Weinigel C; Rummler S; Northoff H; Laufer S; Maier TJ; Radmark O; Samuelsson B; Koeberle A; Sautebin L; Werz O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1186-1194
Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules
Martinez-Bravo M-J; Wahlund CJE; Qazi KR; Moulder R; Lukic A; Radmark O; Lahesmaa R; Grunewald J; Eklund A; Gabrielsson S
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1343-1354.e6
Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways
Dietz K; Jimenez MDLR; Gollwitzer ES; Chaker AM; Zissler UM; Radmark OP; Baarsma HA; Koenigshoff M; Schmidt-Weber CB; Marsland BJ; Esser-von Bieren J
Article: JOURNAL OF LIPID RESEARCH. 2016;57(9):1659-1669
Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C₄ to leukotriene D₄
Lukic A; Ji J; Idborg H; Samuelsson B; Palmberg L; Gabrielsson S; Radmark O
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016;26(15):3547-3551
Kinetic investigation of human 5-lipoxygenase with arachidonic acid
Mittal M; Kumar RB; Balagunaseelan N; Hamberg M; Jegerschold C; Radmark O; Haeggstrom JZ; Rinaldo-Matthis A
Article: ONCOTARGET. 2016;7(28):44350-44364
Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and-186 expression: Novel mechanism of VEGF modulation in prostate cancer
Terzuoli E; Donnini S; Finetti F; Nesi G; Villari D; Hanaka H; Radmark O; Giachetti A; Ziche M
Article: FASEB JOURNAL. 2016;30(1):276-285
Time-resolved in situ assembly of the leukotriene-synthetic 5-lipoxygenase/5-lipoxygenase-activating protein complex in blood leukocytes
Gerstmeier J; Weinigel C; Rummler S; Radmark O; Werz O; Garscha U
Article: PLOS ONE. 2016;11(3):e0152116
Structural and Functional Analysis of Calcium Ion Mediated Binding of 5-Lipoxygenase to Nanodiscs
Kumar RB; Zhu L; Idborg H; Radmark O; Jakobsson P-J; Rinaldo-Matthis A; Hebert H; Jegerschold C
Article: FASEB JOURNAL. 2015;29(12):5029-5043
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein
Lehmann C; Homann J; Ball A-K; Bloecher R; Kleinschmidt TK; Basavarajappa D; Angioni C; Ferreiros N; Haefner A-K; Radmark O; Proschak E; Haeggstrom JZ; Geisslinger G; Parnham MJ; Steinhilber D; Kahnt AS
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2015;100:33-40
Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes
Mahshid Y; Markoutsa S; Dincbas-Renqvist V; Sueruen D; Christensson B; Sander B; Bjorkholm M; Sorg BL; Radmark O; Claesson H-E
Article: ENDOCRINE-RELATED CANCER. 2015;22(4):665-678
mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity
Finetti F; Terzuoli E; Giachetti A; Santi R; Villari D; Hanaka H; Radmark O; Ziche M; Donnini S
Article: NATURE CELL BIOLOGY. 2014;16(12):1180-1191
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Angeli JPF; Schneider M; Proneth B; Tyurina YY; Tyurin VA; Hammond VJ; Herbach N; Aichler M; Walch A; Eggenhofer E; Basavarajappa D; Radmark O; Kobayashi S; Seibt T; Beck H; Neff F; Esposito I; Wanke R; Foerster H; Yefremova O; Heinrichmeyer M; Bornkamm GW; Geissler EK; Thomas SB; Stockwell BR; O'Donnell VB; Kagan VE; Schick JA; Conrad M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1841(10):1538-1547
Stabilisation and characterisation of the isolated regulatory domain of human 5-lipoxygenase
Schroeder M; Haefner A-K; Hofmann B; Radmark O; Tumulka F; Abele R; Doetsch V; Steinhilber D
Article: PHARMACOLOGICAL RESEARCH. 2014;87:1-7
In vivo sex differences in leukotriene biosynthesis in zymosan-induced peritonitis
Rossi A; Pergola C; Pace S; Radmark O; Werz O; Sautebin L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(31):11371-11376
Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis
Basavarajappa D; Wan M; Lukic A; Steinhilber D; Samuelsson B; Radmark O
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2014;545:179-185
A mutation interfering with 5-lipoxygenase domain interaction leads to increased enzyme activity
Ryge MR; Tanabe M; Provost P; Persson B; Chen X; Funk CD; Rinaldo-Matthis A; Hofmann B; Steinhilber D; Watanabe T; Samuelsson B; Radmark O
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(7):1578-1588
Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE₂ to promote tumor growth and to inhibit T cell activation
Sha W; Olesch C; Hanaka H; Radmark O; Weigert A; Bruene B
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(2):293-299
Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis
Loell I; Munters LA; Pandya J; Zong M; Alexanderson H; Fasth AE; Hallengren CS; Radmark O; Lundberg IE; Jakobsson P-J; Korotkova M
Article: ONCOGENE. 2012;31(29):3457-3466
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity
Donnini S; Finetti F; Terzuoli E; Giachetti A; Iniguez MA; Hanaka H; Fresno M; Radmark O; Ziche M
Article: ALLERGY. 2012;67(7):911-919
Bronchoalveolar lavage fluid exosomes contribute to cytokine and leukotriene production in allergic asthma
Paredes PT; Esser J; Admyre C; Nord M; Rahman QK; Lukic A; Radmark O; Gronneberg R; Grunewald J; Eklund A; Scheynius A; Gabrielsson S
Article: FASEB JOURNAL. 2011;25(10):3377-3387
Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes
Pergola C; Rogge A; Dodt G; Northoff H; Weinigel C; Barz D; Radmark O; Sautebin L; Werz O
Article: FASEB JOURNAL. 2011;25(4):1417-1427
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
Esser J; Gehrmann U; Salvado MD; Wetterholm A; Haeggstrom JZ; Samuelsson B; Gabrielsson S; Scheynius A; Radmark O
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(5):1032-1040.e4
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
Esser J; Gehrmann U; D'Alexandri FL; Hidalgo-Estevez AM; Wheelock CE; Scheynius A; Gabrielsson S; Radmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(36):15774-15779
12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases
Conrad M; Sandin A; Foerster H; Seiler A; Frijhoff J; Dagnell M; Bornkamm GW; Radmark O; van Huijsduijnen RH; Aspenstrom P; Boehmer F; Ostman A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):105-110
Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis
Radmark O; Samuelsson B
Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;395(4):884-896
Calcitriol Upregulates Open Chromatin and Elongation Markers at Functional Vitamin D Response Elements in the Distal Part of the 5-Lipoxygenase Gene
Stoffers KL; Sorg BL; Seuter S; Rau O; Radmark O; Steinhilber D
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(1):49-57
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity.
Katryniok C; Schnur N; Gillis A; von Knethen A; Sorg BL; Looijenga L; Rådmark O; Steinhilber D
Article: BIOCHEMICAL JOURNAL. 2009;425(1):265-274
Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102
Esser J; Rakonjac M; Hofmann B; Fischer L; Provost P; Schneider G; Steinhilber D; Samuelsson B; Radmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(44):18757-18762
Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells
Hanaka H; Pawelzik S-C; Johnsen JI; Rakonjac M; Terawaki K; Rasmuson A; Sveinbjornsson B; Schumacher MC; Hamberg M; Samuelsson B; Jakobsson P-J; Kogner P; Radmark O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2009;66(16):2759-2771
Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo
Feisst C; Pergola C; Rakonjac M; Rossi A; Koeberle A; Dodt G; Hoffmann M; Hoernig C; Fischer L; Steinhilber D; Franke L; Schneider G; Radmark O; Sautebin L; Werz O
Article: JOURNAL OF LIPID RESEARCH. 2009;50(Suppl):S40-S45
5-Lipoxygenase: mechanisms of regulation
Radmark O; Samuelsson B
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1789(2):99-108
Human Dicer C-terminus functions as a 5-lipoxygenase binding domain
Dincbas-Renqvist V; Pepin G; Rakonjac M; Plante I; Ouellet DL; Hermansson A; Goulet I; Doucet J; Samuelsson B; Radmark O; Provost P
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83
Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids
Gheorghe KR; Korotkova M; Catrina AI; Backman L; Af Klint E; Claesson H-E; Radmark O; Jakobsson P-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19881-19886
ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma
Pergola C; Dodt G; Rossi A; Neunhoeffer E; Lawrenz B; Northoff H; Samuelsson B; Radmark O; Sautebin L; Werz O
Article: CELL METABOLISM. 2008;8(3):237-248
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death
Seiler A; Schneider M; Foerster H; Roth S; Wirth EK; Culmsee C; Plesnila N; Kremmer E; Radmark O; Wurst W; Bornkamm GW; Schweizer U; Conrad M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(10):1271-1282
The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes
Schnur N; Seuter S; Katryniok C; Radmark O; Steinhilber D
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(7):864-872
Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene
Seuter S; Vaisanen S; Radmark O; Carlberg C; Steinhilber D
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):162-174
5-Lipoxygenase:: Regulation and possible involvement in atherosclerosis
Radmark O; Samuelsson B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(35):13150-13155
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A₄ production
Rakonjac M; Fischer L; Provost P; Werz O; Steinhilbert D; Samuelsson B; Radmark O
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1761(7):686-697
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site
Sorg BL; Klan N; Seuter S; Dishart D; Radmark O; Habenicht A; Carlberg C; Werz O; Steinhilber D
Article: CELL CALCIUM. 2006;39(6):529-537
Arachidonic acid is a physiological activator of the ryanodine receptor in pancreatic β-cells
Woolcott OO; Gustafsson AJ; Dzabic M; Pierro C; Tedeschi P; Sandgren J; Bari MR; Hoa NK; Bianchi M; Rakonjac M; Radmark O; Ostenson C-G; Islam MS
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1738(1-3):37-47
GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site
Dishart D; Schnur N; Klan N; Werz O; Steinhilber D; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(37):13164-13169
Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells
Werz O; Tretiakova I; Michel A; Ulke-Lemee A; Hörnig M; Franke L; Schneider G; Samuelsson B; Radmark O; Steinhilber D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):26913-26921
1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain
Hörning C; Albert D; Fischer L; Hörnig M; Rådmark O; Steinhilber D; Werz O
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2005;1749(1):123-131
Mutation analysis of the human 5-lipoxygenase C-terminus:: Support for a stabilizing C-terminal loop
Okamoto H; Hammarberg T; Zhang YY; Persson B; Watanabe T; Samuelsson B; Rådmark O
Article: PROTEIN AND PEPTIDE LETTERS. 2005;12(3):295-297
C-terminus of p47^phox is required for interaction with leukocyte type rat 12-lipoxygenase
Tanabe M; Kamitani H; Watanabe T; Rådmark O
Article: LIPIDS. 2005;40(3):249-257
Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase-10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid
Butovich IA; Hamberg M; Rådmark O
Article: MITOCHONDRIAL DNA. 2005;16(1):65-68
Cloning of rat p47^phox and comparison with human p47^phox
Tanabe M; Rådmark O; Watanabe T; Shiose A; Sumimoto H
Article: JOURNAL OF BIOMOLECULAR NMR. 2004;30(3):353-356
Letter to the Editor:: NMR structure of human coactosin-like protein
Liepinsh E; Rakonjac M; Boissonneault B; Provost P; Samuelsson B; Rådmark O; Otting G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(44):42846-42853
The C2-like β-barrel domain mediates the Ca²⁺-dependent resistance of 5-lipoxygenase activity against inhibition by glutathione peroxidase-1
Bürkert E; Arnold C; Hammarberg T; Rådmark O; Steinhilber D; Werz O
Article: NATURE. 2003;425(6956):415-419
The nuclear RNase III Drosha initiates microRNA processing
Lee Y; Ahn C; Han JJ; Choi H; Kim J; Yim J; Lee J; Provost P; Rådmark O; Kim S; Kim VN
Article: FASEB JOURNAL. 2003;17(3):949-951
Phosphorylation- and stimulus-dependent inhibition of cellular 5-lipoxygenase activity by nonredox-type inhibitors
Fischer L; Szellas D; Rådmark O; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(3):1238-1243
Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
Spanbroek R; Gräbner R; Lötzer K; Hildner M; Urbach A; Rühling K; Moos MPW; Kaiser B; Cohnert TU; Wahlers T; Zieske A; Plenz G; Robenek H; Salbach P; Kühn H; Rådmark O; Samuelsson B; Habenicht AJR
Article: PROTEIN JOURNAL. 2003;22(2):177-181
Thr94 in bovine myelin basic protein is a second phosphorylation site for 42-kDa mitogen-activated protein kinase (ERK2)
Hirschberg D; Rådmark O; Jörnvall H; Bergman T
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2003;73(1):191-200
Cell type-dependent activation of 5-lipoxygenase by arachidonic acid
Bürkert E; Szellas D; Rådmark O; Steinhilber D; Werz O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):16648-16653
Dicer is required for chromosome segregation and gene silencing in fission yeast cells
Provost P; Silverstein RA; Dishart D; Walfridsson J; Djupedal I; Kniola B; Wright A; Samuelsson B; Rådmark O; Ekwall K
Article: EMBO JOURNAL. 2002;21(21):5864-5874
Ribonuclease activity and RNA binding of recombinant human Dicer
Provost P; Dishart D; Doucet J; Frendewey D; Samuelsson B; Rådmark O
Article: FASEB JOURNAL. 2002;16(9):1441-1443
Extracellular signal-regulated kinases phosphorylate 5-lipoxygenase and stimulate 5-lipoxygenase product formation in leukocytes
Werz O; Bürkert E; Fischer L; Szellas D; Dishart D; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;295(4):985-991
Monocyte-derived soluble protein confers 5-lipoxygenase activity Ca²⁺-dependent
Bürkert E; Rådmark O; Steinhilber D; Werz O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(17):14793-14800
Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
Werz O; Szellas D; Steinhilber D; Rådmark O
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2002;71(3):477-486
Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes
Bürkert E; Rådmark O; Samuelsson B; Steinhilber D; Werz O
Article: BLOOD. 2002;99(3):1044-1052
Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes
Werz O; Bürkert E; Samuelsson B; Rådmark O; Steinhilber D
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(2):783-789
Molecular cloning and functional characterization of mouse coactosin-like protein
Doucet J; Provost P; Samuelsson B; Rådmark O
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2001;70(5):830-838
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line
Werz O; Klemm J; Rådmark O; Samuelsson B
Article: BIOCHEMICAL JOURNAL. 2001;359(Pt 2):255-263
Coactosin-like protein, a human F-actin-binding protein:: critical role lysine-75
Provost P; Doucet J; Stock A; Gerisch G; Samuelsson B; Rådmark O
Article: BIOCHEMISTRY. 2001;40(21):6371-6378
EPR investigation of the active site of recombinant human 5-lipoxygenase:: Inhibition by selenide
Hammarberg T; Kuprin S; Rådmark O; Holmgren A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(19):16520-16527
5-Lipoxygenase interacts with coactosin-like protein
Provost P; Doucet J; Hammarberg T; Gerisch G; Samuelsson B; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(9):5152-5157
IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression
Spanbroek R; Hildner M; Köhler A; Müller A; Zintl F; Kühn H; Rådmark O; Samuelsson B; Habenicht AJR
Article: BLOOD. 2001;97(8):2487-2495
Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes
Werz O; Klemm J; Samuelsson B; Rådmark O
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(49):38787-38793
The N-terminal domain of 5-lipoxygenase binds calcium and mediates calcium stimulation of enzyme activity
Hammarberg T; Provost P; Persson B; Rådmark O
Article: BLOOD. 2000;96(12):3857-3865
5-lipoxygenase expression in dendritic cells generated from CD34⁺ hematopoietic progenitors and in lymphoid organs
Spanbroek R; Hildner M; Steinhilber D; Fusenig N; Yoneda K; Rådmark O; Samuelsson B; Habenicht AJR
Article: BIOCHEMICAL JOURNAL. 2000;351(Pt 3):697-707
Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences
Zhang YY; Hammarberg T; Radmark O; Samuelsson B; Ng CF; Funk CD; Loscalzo J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(10):5261-5266
5-lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases
Werz O; Klemm J; Samuelsson B; Rådmark O
Article: BIOCHEMISTRY. 2000;39(7):1840-1848
Mg²⁺ activates 5-lipoxygenase in vitro:: Dependency on concentrations of phosphatidylcholine and arachidonic acid
Reddy KV; Hammarberg T; Rådmark O
Article: BIOCHEMISTRY. 1999;38(14):4441-4447
5-lipoxygenase binds calcium
Hammarberg T; Rådmark O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(5):1881-1885
Interaction of 5-lipoxygenase with cellular proteins
Provost P; Samuelsson B; Rådmark O
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 1998;19(2):316-323
Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants
Silverman ES; Du J; De Sanctis GT; Rådmark O; Samuelsson B; Drazen JM; Collins T
Article: FEBS JOURNAL. 1998;254(2):275-281
Calcitriol and transforming growth factor-β upregulate 5-lipoxygenase mRNA expression by increasing gene transcription and mRNA maturation
Härle D; Rådmark O; Samuelsson B; Steinhilber D
Article: BIOCHEMICAL PHARMACOLOGY. 1998;55(6):863-871
Effects of 1-chloro-2,4,6-trinitrobenzene on 5-lipoxygenase activity and cellular leukotriene synthesis
Lasson PKA; Hammarberg T; Johnsson T; Lindgren J; Rådmark O; Claesson HE
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(2):663-668
5-Lipoxygenase expression in Langerhans cells of normal human epidermis
Spanbroek R; Stark HJ; Janssen-Timmen U; Kraft S; Hildner M; Andl T; Bosch FX; Fusenig NE; Bieber T; Rådmark O; Samuelsson B; Habenicht AJR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(15):6966-6970
EXPRESSION OF 5-LIPOXYGENASE IN DIFFERENTIATING HUMAN SKIN KERATINOCYTES
JANSSENTIMMEN U; VICKERS PJ; WITTIG U; LEHMANN WD; STARK HJ; FUSENIG NE; ROSENBACH T; RADMARK O; SAMUELSSON B; HABENICHT AJR
Article: FEBS JOURNAL. 1995;230(2):401-407
MUTATIONS AT THE C-TERMINAL ISOLEUCINE AND OTHER POTENTIAL IRON LIGANDS OF 5-LIPOXYGENASE
HAMMARBERG T; ZHANG YY; LIND B; RADMARK O; SAMUELSSON B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(1):107-111
SEQUENTIAL INDUCTION OF 5-LIPOXYGENASE GENE-EXPRESSION AND ACTIVITY IN MONO-MAC-6 CELLS BY TRANSFORMING GROWTH-FACTOR-BETA AND 1,25-DIHYDROXYVITAMIN-D3
BRUNGS M; RADMARK O; SAMUELSSON B; STEINHILBER D
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Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1851(4):331-339
5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease
Radmark O; Werz O; Steinhilber D; Samuelsson B
Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2010;268(1):5-14
Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer
Radmark O; Samuelsson B
Review: TRENDS IN BIOCHEMICAL SCIENCES. 2007;32(7):332-341
5-Lipoxygenase:: regulation of expression and enzyme activity
Radmark O; Werz O; Steinhilber D; Samuelsson B
Review: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;338(1):102-110
Regulation of 5-lipoxygenase enzyme activity
Rådmark O; Samuelsson B
Editorial comment: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(7):1140-1142
5-lipoxygenase-derived leukotrienes -: Mediators also of atherosclerotic inflammation
Rådmark O
Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2002;68-9:211-234
Arachidonate 5-lipoxygenase
Rådmark O
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2002;507:117-121
Calcium binding to 5-lipoxygenase
Hammarberg T; Reddy KV; Persson B; Rådmark O
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2 Pt 2):S11-S15
The molecular biology and regulation of 5-lipoxygenase.
Rådmark OP
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;469:105-111
Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line monocytic 6 by transforming growth factor-β and 1,25-dihydroxyvitamin D₃
Härle D; Rådmark O; Samuelsson B; Steinhilber D
Published conference paper: JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING. 1995;12(2-3):171-184
ARACHIDONATE 5-LIPOXYGENASE
RADMARK O
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:449-451
TRANSFORMING GROWTH-FACTOR-BETA AND 1,25-DIHYDROXYVITAMIN D-3 INDUCE 5-LIPOXYGENASE ACTIVITY DURING MYELOID CELL MATURATION
STEINHILBER D; BRUNGS M; RADMARK O; SAMUELSSON B
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:329-331
5-LIPOXYGENASE EXPRESSION IN CULTURED HUMAN KERATINOCYTES
JANSSENTIMMEN U; VICKERS P; BEILECKE U; LEHMANN WD; STARK HJ; FUSENIG NE; ROSENBACH T; GOERIG M; RADMARK O; SAMUELSSON B; HABENICHT AJR
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:1-9
5-LIPOXYGENASE - STRUCTURE AND STABILITY OF RECOMBINANT ENZYME, REGULATION IN MONO-MAC-6 CELLS
RADMARK O; ZHANG YY; HAMMARBERG T; LIND B; HAMBERG M; BRUNGS M; STEINHILBER D; SAMUELSSON B

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