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Om mig

Som Senior Lab Manager

I have previously been working as a Senior Researcher in the area of neuroscience at KI and Umeå University with a main focus on two major hallmarks of Alzheimer’s disease i.e., impairment of nicotinic acetylcholine receptors and accumulation of beta amyloid protein in the brain of affected patients. Since Jan. 2013, I am employed as Senior Lab Manager at the Division Molecular Toxicology where I deal with administrative responsibilities including implementation of electronic laboratory notebooks, procurement and maintenance of laboratory equipment, implementation and follow-up of safety measures in the laboratory, risk assessment of chemicals and experimental procedures, handling invoices, and so on. In addition, I am involved in course organizing, teaching and supervising of PhD students and post docs, collecting and adapting protocols for common procedures as well as specific research in the field of inflammation.

Jag agerar också som:

- Institutionens förståndare för brandfaliga vara
- Enhetens skyddsombud
- Enhetens Web-manager

 

Utbildning

2009-   Post-doc at the Cell Biology & Nutrition, University of Houston. TX, USA

2004-   Postdoc at Department of Neuroscience, Health care and Society, Karolinska Institute, Sweden

2003-   Doctoral Degree at Department of Neuroscience, Health care and Society, Karolinska Institute, Sweden

2001-   Medical licentiate at Department of Neuroscience, Health care and Society, Karolinska Institute, Sweden

1999-   Master's Degree in Biomedical Laboratory Science at Karolinska Institute, Sweden

Forskningsbeskrivning

Programmed cell clearance and its role in inflammation

Tissue homeostasis is maintained through the concerted actions of programmed cell death and programmed cell clearance. The latter is a genetically programmed mechanism for the disposal of apoptotic cells by phagocytic cells including macrophages. Deficits in any part of this machinery may result in chronic inflammatory and autoimmune related disease. Thus, these deficits need to be discovered and therapeutic steps need to be taken. To date, some proteins and enzymes such as aminophospholipid translocase or phospholipid scramblase have been suggested to play important role in mechanisms of phagocytosis but we are far from uncovering all the involved cellular mechanisms that regulate the recognition and removal of dying cells by macrophages. The goal of our research is to investigate the mechanism of apoptosis and phagocytosis and to study specifically the role of neutrophils and the production of so-called neutrophil extracellular traps (NETs).

Publikationer

Serum metabolomic biomarkers of dementia
Mousavi M, Jonsson P, Antti H, Adolfsson R, Nordin A, Bergdahl J, et al
Dementia and geriatric cognitive disorders extra 2014;4(2):252-62

Apolipoprotein ε4 modulates phenotype of butyrylcholinesterase in CSF of patients with Alzheimer's disease
Darreh-shori T, Siawesh M, Mousavi M, Andreasen N, Nordberg A
Journal of Alzheimer's disease : JAD 2012;28(2):443-58

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease
Kadir A, Marutle A, Gonzalez D, Schöll M, Almkvist O, Mousavi M, et al
Brain : a journal of neurology 2011;134(Pt 1):301-17

Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons
Wicklund L, Leão Rn, Strömberg Am, Mousavi M, Hovatta O, Nordberg A, et al
PloS one 2010;5(12):e15600-

Different Cholinesterase Inhibitor Effects on CSF Cholinesterases in Alzheimer Patients
Nordberg A, Darreh-shori T, Peskind E, Soininen H, Mousavi M, Eagle G, et al
CURRENT ALZHEIMER RESEARCH 2009;6(1):4-14

Nicotinic receptor agonists and antagonists increase sAPP alpha secretion and decrease A beta levels in vitro
Mousavi M, Hellstrom-lindahl E
NEUROCHEMISTRY INTERNATIONAL 2009;54(3-4):237-44

Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: Effect of nicotine treatment
Hedberg Mm, Svedberg Mm, Mustafiz T, Yu Wf, Mousavi M, Guan Zz, et al
NEUROSCIENCE 2008;152(1):223-33

Regulation of alpha- and beta-secretase activity by oxysterols: Cerebrosterol stimulates processing of APP via the alpha-secretase pathway
Famer D, Meaney S, Mousavi M, Nordberg A, Bjorkhem I, Crisby M
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;359(1):46-50

Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells
Nilbratt M, Friberg L, Mousavi M, Marutle A, Nordberg A
JOURNAL OF NEUROSCIENCE RESEARCH 2007;85(3):504-14

Expression of the alpha 7, alpha 4 and alpha 3 nicotinic receptor subtype in the brain and adrenal medulla of transgenic mice carrying genes coding for human AChE and beta-amyloid
Mousavi M, Nordberg A
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2006;24(4):269-73

Lovastatin stimulates up-regulation of alpha 7 nicotinic receptors in cultured neurons without cholesterol dependency, a mechanism involving production of the alpha-form of secreted amyloid precursor protein
Xiu J, Nordberg A, Shan Kr, Yu Wf, Olsson Jm, Nordman T, et al
JOURNAL OF NEUROSCIENCE RESEARCH 2005;82(4):531-41

Reduced levels of A beta 40 and A beta 42 in brains of smoking controls and Alzheimer's patients
Hellstrom-lindahl E, Mousavi M, Ravid R, Nordberg A
NEUROBIOLOGY OF DISEASE 2004;15(2):351-60

Selective changes in expression level of different nicotinic receptor subtypes in the brain cortex and adrenal medulla of mice over-expressing human acetylcholinestrase and mice carrying human mutated gene for APP
Mousavi M
NEUROBIOLOGY OF AGING 2004;:S438-S438

Selective changes in expression of different nicotinic receptor subtypes in brain and adrenal glands of mice carrying human mutated gene for APP or over-expressing human acetylcholinestrase
Mousavi M, Bednar I, Nordberg A
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2004;22(7):545-9

Upregulation of alpha7 nicotinic receptor induced by statins involves increased alpha-form of secreted APP
Guan Zz, Jin X, Shan Kr, Yu Wf, Nordman T, Olsson Jm, et al
NEUROBIOLOGY OF AGING 2004;:S440-S441

Protein and mRNA levels of nicotinic receptors in brain of tobacco using controls and patients with Alzheimer's disease
Mousavi M, Hellstrom-lindahl E, Guan Zz, Shan Kr, Ravid R, Nordberg A
NEUROSCIENCE 2003;122(2):515-20

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)
Nordberg A, Hellstrom-lindahl E, Lee M, Johnson M, Mousavi M, Hall R, et al
JOURNAL OF NEUROCHEMISTRY 2002;81(3):655-8

Effects of nicotine on 1-40 and 1-42 beta amyloid levels and nicotinic receptors in brains from Alzheimer's patients
Hellstrom-lindahl E, Mousavi M, Nordberg A, Ravid R
NEUROBIOLOGY OF AGING 2002;23(1):S270-S270

Nicotine treatment attenuates beta-amyloidosis in brain of transgenic APPsw mice
Bednar I, Hellstrom-lindahl E, Mousavi M, Nordberg A, Lee M, Johnson M, et al
NEUROBIOLOGY OF AGING 2002;23(1):S270-S270

Selective changes in the levels of nicotinic acetylcholine receptor protein and of corresponding mRNA species in the brains of patients with Parkinson's disease
Guan Zz, Nordberg A, Mousavi M, Rinne Jo, Hellstrom-lindahl E
BRAIN RESEARCH 2002;956(2):358-66

Selective nicotinic receptor consequences in APP(SWE) transgenic mice
Bednar I, Paterson D, Marutle A, Pham Tm, Svedberg M, Hellstrom-lindahl E, et al
MOLECULAR AND CELLULAR NEUROSCIENCE 2002;20(2):354-65

The effect of nicotine on expression of protein and mRNA level of nicotinic receptors in Alzheimer's disease
Mousavi M, Hellsrom-lindahl E, Guan Zz, Shan Kr, Ravid R, Nordberg A
NEUROBIOLOGY OF AGING 2002;23(1):S72-S72

Expression of nicotinic acetylcholine receptors in human and rat adrenal medulla
Mousavi M, Hellstrom-lindahl E, Guan Zz, Bednar I, Nordberg A
LIFE SCIENCES 2001;70(5):577-90

Reduced expression of neuronal nicotinic acetylcholine receptors during the early stages of damage by oxidative stress in PC12 cells
Guan Zz, Zhang X, Mousavi M, Tian Jy, Unger C, Nordberg A
JOURNAL OF NEUROSCIENCE RESEARCH 2001;66(4):551-8

Regional distribution of nicotinic receptor subunit mRNAs in human brain: comparison between Alzheimer and normal brain
Hellstrom-lindahl E, Mousavi M, Zhang X, Ravid R, Nordberg A
MOLECULAR BRAIN RESEARCH 1999;66(1-2):94-103

Characterization of the gene for the membrane and secretory form of the IgM heavy-chain constant region gene (C mu) of the cow (Bos taurus)
Mousavi M, Rabbani H, Pilstrom L, Hammarstrom L
IMMUNOLOGY 1998;93(4):581-8

Chronic ethanol treatment decreases [H-3]epibatidine and [H-3]nicotine binding and differentially regulates mRNA levels of nicotinic acetylcholine receptor subunits expressed in M10 and SH-SY5Y neuroblastoma cells
Gorbounova O, Svensson Al, Jonsson P, Mousavi M, Miao H, Hellstrom-lindahl E, et al
JOURNAL OF NEUROCHEMISTRY 1998;70(3):1134-42

Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord
Hellstrom-lindahl E, Gorbounova O, Seiger A, Mousavi M, Nordberg A
DEVELOPMENTAL BRAIN RESEARCH 1998;108(1-2):147-60

Characterization of the bovine epsilon gene
Mousavi M, Rabbani H, Hammarstrom L
IMMUNOLOGY 1997;92(3):369-73

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