Investigation of mechanism and functional and biochemical aspects of Tartrate resistant acid phosphatase (TRAP) during cancer progression.
Specifically, I study TRAP´s influence on cancer cell functions and signaling pathways involved. Additionally, we screen for novel small molecule inhibitors against TRAP as a tool to unravel TRAP´s mechanism of action and for a possible pharmacological application. Early discovery of the risk for growth and metastasis of a tumor can influence the choice of therapy and the outcome of the patient. We propose TRAP as a marker for the decision of treatment to predict the patient´s outcome and as a potential therapeutic target.