Utvalda publikationer STARGET

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Christer Betsholtz


The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
Gaengel K, Niaudet C, Hagikura K, Laviña B, Siemsen B, Muhl L, et al
Dev. Cell 2012 Sep;23(3):587-99

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
Armulik A, Genové G, Betsholtz C
Dev. Cell 2011 Aug;21(2):193-215

Podocin-green fluorescence protein allows visualization and functional analysis of podocytes.
He B, Ebarasi L, Hultenby K, Tryggvason K, Betsholtz C
J. Am. Soc. Nephrol. 2011 Jun;22(6):1019-23

Pericytes regulate the blood-brain barrier.
Armulik A, Genové G, Mäe M, Nisancioglu M, Wallgard E, Niaudet C, et al
Nature 2010 Nov;468(7323):557-61

The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade.
Nisancioglu M, Betsholtz C, Genové G
Cancer Res. 2010 Jun;70(12):5109-15

Endothelial-mural cell signaling in vascular development and angiogenesis.
Gaengel K, Genové G, Armulik A, Betsholtz C
Arterioscler. Thromb. Vasc. Biol. 2009 May;29(5):630-8

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, et al
Nature 2008 Jul;454(7204):656-60

Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature.
Wallgard E, Larsson E, He L, Hellström M, Armulik A, Nisancioglu M, et al
Arterioscler. Thromb. Vasc. Biol. 2008 Aug;28(8):1469-76

Role of platelet-derived growth factors in physiology and medicine.
Andrae J, Gallini R, Betsholtz C
Genes Dev. 2008 May;22(10):1276-312

The glomerular transcriptome and a predicted protein-protein interaction network.
He L, Sun Y, Takemoto M, Norlin J, Tryggvason K, Samuelsson T, et al
J. Am. Soc. Nephrol. 2008 Feb;19(2):260-8

Lorenz Poellinger


Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions.
Lee K, Lim S, Orlov Y, Yit L, Yang H, Ang L, et al
PLoS Genet. 2011 Jun;7(6):e1002130

Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.
Ruas J, Berchner-Pfannschmidt U, Malik S, Gradin K, Fandrey J, Roeder R, et al
J. Biol. Chem. 2010 Jan;285(4):2601-9

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.
Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, et al
Proc. Natl. Acad. Sci. U.S.A. 2009 Aug;106(32):13481-6

Generating specificity and diversity in the transcriptional response to hypoxia.
Lendahl U, Lee K, Yang H, Poellinger L
Nat. Rev. Genet. 2009 Dec;10(12):821-32

Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms.
Poellinger L, Lendahl U
Curr. Opin. Genet. Dev. 2008 Oct;18(5):449-54

Notch signaling mediates hypoxia-induced tumor cell migration and invasion.
Sahlgren C, Gustafsson M, Jin S, Poellinger L, Lendahl U
Proc. Natl. Acad. Sci. U.S.A. 2008 Apr;105(17):6392-7

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.
Zheng X, Linke S, Dias J, Zheng X, Gradin K, Wallis T, et al
Proc. Natl. Acad. Sci. U.S.A. 2008 Mar;105(9):3368-73

Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2.
Nakamura H, Tanimoto K, Hiyama K, Yunokawa M, Kawamoto T, Kato Y, et al
Oncogene 2008 Jul;27(30):4200-9

Epidermal sensing of oxygen is essential for systemic hypoxic response.
Boutin A, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, et al
Cell 2008 Apr;133(2):223-34

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.
Yamashita T, Ohneda O, Nagano M, Iemitsu M, Makino Y, Tanaka H, et al
Mol. Cell. Biol. 2008 Feb;28(4):1285-97

Kristian Pietras


Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.
Anderberg C, Cunha S, Zhai Z, Cortez E, Pardali E, Johnson J, et al
J. Exp. Med. 2013 Mar;210(3):563-79

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression.
Franco M, Roswall P, Cortez E, Hanahan D, Pietras K
Blood 2011 Sep;118(10):2906-17

Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.
Albrecht I, Kopfstein L, Strittmatter K, Schomber T, Falkevall A, Hagberg C, et al
PLoS ONE 2010 Nov;5(11):e14109

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma.
Haller B, Bråve A, Wallgard E, Roswall P, Sunkari V, Mattson U, et al
Oncogene 2010 Jul;29(30):4276-86

Hallmarks of cancer: interactions with the tumor stroma.
Pietras K, Ostman A
Exp. Cell Res. 2010 May;316(8):1324-31

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.
Cunha S, Pardali E, Thorikay M, Anderberg C, Hawinkels L, Goumans M, et al
J. Exp. Med. 2010 Jan;207(1):85-100

On the origin of cancer-associated fibroblasts.
Anderberg C, Pietras K
Cell Cycle 2009 May;8(10):1461-2

The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth.
Ehnman M, Li H, Fredriksson L, Pietras K, Eriksson U
Oncogene 2009 Jan;28(4):534-44

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts.
Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, et al
Cancer Res. 2009 Jan;69(1):369-78

Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.
Pietras K, Pahler J, Bergers G, Hanahan D
PLoS Med. 2008 Jan;5(1):e19

Arne Östman


STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer.
Peña C, Céspedes M, Lindh M, Kiflemariam S, Mezheyeuski A, Edqvist P, et al
Cancer Res. 2013 Feb;73(4):1287-97

The tumor microenvironment controls drug sensitivity.
Ostman A
Nat. Med. 2012 Sep;18(9):1332-4

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
Godfrey R, Arora D, Bauer R, Stopp S, Müller J, Heinrich T, et al
Blood 2012 May;119(19):4499-511

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
Conrad M, Sandin A, Förster H, Seiler A, Frijhoff J, Dagnell M, et al
Proc. Natl. Acad. Sci. U.S.A. 2010 Sep;107(36):15774-9

Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.
Saito R, Micke P, Paulsson J, Augsten M, Peña C, Jönsson P, et al
Cancer Res. 2010 Apr;70(7):2644-54

Hallmarks of cancer: interactions with the tumor stroma.
Pietras K, Ostman A
Exp. Cell Res. 2010 May;316(8):1324-31

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin C, et al
Am. J. Pathol. 2009 Jul;175(1):334-41

Stromal signature identifies basal breast cancers.
Wennmalm K, Ostman A, Bergh J
Nat. Med. 2009 Mar;15(3):237-8; author reply 238

CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth.
Augsten M, Hägglöf C, Olsson E, Stolz C, Tsagozis P, Levchenko T, et al
Proc. Natl. Acad. Sci. U.S.A. 2009 Mar;106(9):3414-9

Cancer-associated fibroblasts and tumor growth--bystanders turning into key players.
Ostman A, Augsten M
Curr. Opin. Genet. Dev. 2009 Feb;19(1):67-73

Ulf Eriksson


Results of renal replacement therapy in Europe, 1980 to 1987. Registration Committee of the EDTA-ERA.
Brunner F, Selwood N
Am. J. Kidney Dis. 1990 May;15(5):384-96

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.
Hagberg C, Mehlem A, Falkevall A, Muhl L, Fam B, Ortsäter H, et al
Nature 2012 Oct;490(7420):426-30

Vascular endothelial growth factor B controls endothelial fatty acid uptake.
Hagberg C, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, et al
Nature 2010 Apr;464(7290):917-21

The effects of VEGF-R1 and VEGF-R2 ligands on angiogenic responses and left ventricular function in mice.
Huusko J, Merentie M, Dijkstra M, Ryhänen M, Karvinen H, Rissanen T, et al
Cardiovasc. Res. 2010 Apr;86(1):122-30

PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries.
Karvinen H, Rutanen J, Leppänen O, Lach R, Levonen A, Eriksson U, et al
Eur. J. Clin. Invest. 2009 Apr;39(4):320-7

Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Lähteenvuo J, Lähteenvuo M, Kivelä A, Rosenlew C, Falkevall A, Klar J, et al
Circulation 2009 Feb;119(6):845-56

Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts.
Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, et al
Cancer Res. 2009 Jan;69(1):369-78

The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth.
Ehnman M, Li H, Fredriksson L, Pietras K, Eriksson U
Oncogene 2009 Jan;28(4):534-44

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke.
Su E, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, et al
Nat. Med. 2008 Jul;14(7):731-7

Tissue plasminogen activator-mediated PDGF signaling and neurovascular coupling in stroke.
Su E, Fredriksson L, Schielke G, Eriksson U, Lawrence D
J. Thromb. Haemost. 2009 Jul;7 Suppl 1():155-8

Jonas Bergh


Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression.
Lindström L, Karlsson E, Wilking U, Johansson U, Hartman J, Lidbrink E, et al
J. Clin. Oncol. 2012 Jul;30(21):2601-8

FACT: an open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer.
Bergh J, Jönsson P, Lidbrink E, Trudeau M, Eiermann W, Brattström D, et al
J. Clin. Oncol. 2012 Jun;30(16):1919-25

Hurdles in anticancer drug development from a regulatory perspective.
Jonsson B, Bergh J
Nat Rev Clin Oncol 2012 02;9(4):236-43

First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study.
Bergh J, Bondarenko I, Lichinitser M, Liljegren A, Greil R, Voytko N, et al
J. Clin. Oncol. 2012 Mar;30(9):921-9

Insights into the place of fulvestrant for the treatment of advanced endocrine responsive breast cancer.
Howell A, Bergh J
J. Clin. Oncol. 2010 Oct;28(30):4548-50

Impact of tumour size on axillary involvement and distant dissemination in breast cancer.
Koscielny S, Arriagada R, Adolfsson J, Fornander T, Bergh J
Br. J. Cancer 2009 Sep;101(6):902-7

Stromal signature identifies basal breast cancers.
Wennmalm K, Ostman A, Bergh J
Nat. Med. 2009 Mar;15(3):237-8; author reply 238

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer.
Farmer P, Bonnefoi H, Anderle P, Cameron D, Wirapati P, Wirapati P, et al
Nat. Med. 2009 Jan;15(1):68-74

Quo vadis with targeted drugs in the 21st century?
Bergh J
J. Clin. Oncol. 2009 Jan;27(1):2-5

Cost-effectiveness of HER2 testing and 1-year adjuvant trastuzumab therapy for early breast cancer.
Lidgren M, Jönsson B, Rehnberg C, Willking N, Bergh J
Ann. Oncol. 2008 Mar;19(3):487-95

Monica Nistér


Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile.
Hägerstrand D, He X, Bradic Lindh M, Hoefs S, Hesselager G, Ostman A, et al
Neuro-oncology 2011 Nov;13(11):1178-91

RAD51 can inhibit PDGF-B-induced gliomagenesis and genomic instability.
Westermark U, Lindberg N, Roswall P, Bråsäter D, Helgadottir H, Hede S, et al
Neuro-oncology 2011 Dec;13(12):1277-87

Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission.
Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlén P, et al
EMBO J. 2011 Jun;30(14):2762-78

Transcription factor PROX1: its role in development and cancer.
Elsir T, Smits A, Lindström M, Nistér M
Cancer Metastasis Rev. 2012 Dec;31(3-4):793-805

Meta-analysis of cancer gene expression signatures reveals new cancer genes, SAGE tags and tumor associated regions of co-regulation.
Kavak E, Unlü M, Nistér M, Koman A
Nucleic Acids Res. 2010 Nov;38(20):7008-21

Silencing of ribosomal protein S9 elicits a multitude of cellular responses inhibiting the growth of cancer cells subsequent to p53 activation.
Lindström M, Nistér M
PLoS ONE 2010 Mar;5(3):e9578

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha.
Seidel S, Garvalov B, Wirta V, von Stechow L, Schänzer A, Meletis K, et al
Brain 2010 Apr;133(Pt 4):983-95

Expression of PROX1 Is a common feature of high-grade malignant astrocytic gliomas.
Elsir T, Eriksson A, Orrego A, Lindström M, Nistér M
J. Neuropathol. Exp. Neurol. 2010 Feb;69(2):129-38

The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation.
Zhao J, Liu T, Jin S, Tomilin N, Castro J, Shupliakov O, et al
J. Cell. Sci. 2009 Jul;122(Pt 13):2252-62


Randall S Johnson


Endothelial cell HIF-1α and HIF-2α differentially regulate metastatic success.
Branco-Price C, Zhang N, Schnelle M, Evans C, Katschinski D, Liao D, et al
Cancer Cell 2012 Jan;21(1):52-65

Tumor vessels are Eph-ing complicated.
Branco-Price C, Johnson R
Cancer Cell 2010 Jun;17(6):533-4

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.
Zhang N, Fu Z, Linke S, Chicher J, Gorman J, Visk D, et al
Cell Metab. 2010 May;11(5):364-78

Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis.
Takeda N, O'Dea E, Doedens A, Kim J, Weidemann A, Stockmann C, et al
Genes Dev. 2010 Mar;24(5):491-501

Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis.
Stockmann C, Kerdiles Y, Nomaksteinsky M, Weidemann A, Takeda N, Doedens A, et al
Proc. Natl. Acad. Sci. U.S.A. 2010 Mar;107(9):4329-34

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.
Weidemann A, Kerdiles Y, Knaup K, Rafie C, Boutin A, Stockmann C, et al
J. Clin. Invest. 2009 Nov;119(11):3373-83

You don't need a PHD to grow a tumor.
Kim J, Johnson R
Dev. Cell 2009 Jun;16(6):781-2

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis.
Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg J, et al
Nature 2008 Dec;456(7223):814-8

Putting the tissue and environmental 'context' into differentiation and gene regulation.
Bray S, Johnson R
Curr. Opin. Genet. Dev. 2008 Oct;18(5):395-6

Epidermal sensing of oxygen is essential for systemic hypoxic response.
Boutin A, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, et al
Cell 2008 Apr;133(2):223-34

Sten Linnarsson


Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino J, Castelo-Branco G, Sinha I, et al
EMBO J. 2012 Sep;31(18):3718-29

RNA-seq analysis reveals different dynamics of differentiation of human dermis- and adipose-derived stromal stem cells.
Jääger K, Islam S, Zajac P, Linnarsson S, Neuman T
PLoS ONE 2012 ;7(6):e38833

Highly multiplexed and strand-specific single-cell RNA 5' end sequencing.
Islam S, Kjällquist U, Moliner A, Zajac P, Fan J, Lönnerberg P, et al
Nat Protoc 2012 Apr;7(5):813-28

Magnetic sequencing.
Linnarsson S
Nat. Methods 2012 Mar;9(4):339, 341

Highly parallel genome-wide expression analysis of single mammalian cells.
Fan J, Chen J, April C, Fisher J, Klotzle B, Bibikova M, et al
PLoS ONE 2012 ;7(2):e30794

Counting absolute numbers of molecules using unique molecular identifiers.
Kivioja T, Vähärautio A, Karlsson K, Bonke M, Enge M, Linnarsson S, et al
Nat. Methods 2011 Nov;9(1):72-4

Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq.
Islam S, Kjällquist U, Moliner A, Zajac P, Fan J, Lönnerberg P, et al
Genome Res. 2011 Jul;21(7):1160-7

En masse in vitro functional profiling of the axonal mechanosensitivity of sensory neurons.
Usoskin D, Zilberter M, Linnarsson S, Hjerling-Leffler J, Uhlén P, Harkany T, et al
Proc. Natl. Acad. Sci. U.S.A. 2010 Sep;107(37):16336-41

Recent advances in DNA sequencing methods - general principles of sample preparation.
Linnarsson S
Exp. Cell Res. 2010 May;316(8):1339-43

Rapid genome sequencing with short universal tiling probes.
Pihlak A, Baurén G, Hersoug E, Lönnerberg P, Metsis A, Linnarsson S
Nat. Biotechnol. 2008 Jun;26(6):676-84

Maria Kasper


Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus.
van Dop W, Rosekrans S, Uhmann A, Jaks V, Offerhaus G, van den Bergh Weerman M, et al
Gut 2013 Mar;62(3):348-57

Basal cell carcinoma - molecular biology and potential new therapies.
Kasper M, Jaks V, Hohl D, Toftgård R
J. Clin. Invest. 2012 Feb;122(2):455-63

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.
Sonkoly E, Lovén J, Xu N, Meisgen F, Wei T, Brodin P, et al
Oncogenesis 2012 Mar;1():e3

Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma.
Asklund T, Henriksson R, Axelsson J, Bergström , Kasper M, Ögren M, et al
Acta Oncol 2013 May;52(4):862-6

Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes.
Kasper M, Jaks V, Are A, Bergström , Schwäger A, Svärd J, et al
Proc. Natl. Acad. Sci. U.S.A. 2011 Mar;108(10):4099-104

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.
Snippert H, Haegebarth A, Kasper M, Jaks V, van Es J, Barker N, et al
Science 2010 Mar;327(5971):1385-9

The hair follicle-a stem cell zoo.
Jaks V, Kasper M, Toftgård R
Exp. Cell Res. 2010 May;316(8):1422-8

Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway.
Schnidar H, Eberl M, Klingler S, Mangelberger D, Kasper M, Hauser-Kronberger C, et al
Cancer Res. 2009 Feb;69(4):1284-92

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.
Jaks V, Barker N, Kasper M, van Es J, Snippert H, Clevers H, et al
Nat. Genet. 2008 Nov;40(11):1291-9