Marianne Farnebos forskargrupp

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Marianne Farnebos forskargrupp karaktäriserar WRAP53 genen och dess roll i cancer.

Mer information finns på den engelska sidan.

Gruppmedlemmar

Marianne Farnebo (maiden name: Hammarsund), PhD, docent , gruppledare
Soniya Dhanjal, postdoc
Stefanie Böhm, postdoc
Dominika Hrossova, postdoc
Rositsa Dueva, postdoc
Christos Coucoravas, doktorand (registrerad 2013)
Chiara Pederiva, doktorand (registrerad 2015)
Sofie Bergstrand, doktorand (registrerad 2017)
Xabier Vergara, FOU-praktikant

Utvalda publikationer

Overexpression of the scaffold WD40 protein WRAP53β enhances the repair of and cell survival from DNA double-strand breaks.
Rassoolzadeh H, Böhm S, Hedström E, Gad H, Helleday T, Henriksson S, et al
Cell Death Dis 2016 06;7():e2267

Splicing controls the ubiquitin response during DNA double-strand break repair.
Pederiva C, Böhm S, Julner A, Farnebo M
Cell Death Differ. 2016 10;23(10):1648-57

The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1.
Rassoolzadeh H, Coucoravas C, Farnebo M
Nucleus 2015 ;6(5):417-24

On the road with WRAP53β: guardian of Cajal bodies and genome integrity.
Henriksson S, Farnebo M
Front Genet 2015 ;6():91

Nuclear expression of WRAP53β is associated with a positive response to radiotherapy and improved overall survival in patients with head and neck squamous cell carcinoma.
Garvin S, Tiefenböck K, Farnebo L, Thunell L, Farnebo M, Roberg K
Oral Oncol. 2015 Jan;51(1):24-30

The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al
Genes Dev. 2014 Dec;28(24):2726-38

WRAP53 promotes cancer cell survival and is a potential target for cancer therapy.
Mahmoudi S, Henriksson S, Farnebo L, Roberg K, Farnebo M
Cell Death Dis 2011 Jan;2():e114

WRAP53 promotes cancer cell survival and is a potential target for cancer therapy.
Mahmoudi S, Henriksson S, Farnebo L, Roberg K, Farnebo M
Cell Death Dis 2011 Jan;2():e114

Increasing the dynamic range of in situ PLA.
Clausson C, Allalou A, Weibrecht I, Mahmoudi S, Farnebo M, Landegren U, et al
Nat. Methods 2011 Oct;8(11):892-3

WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies.
Mahmoudi S, Henriksson S, Weibrecht I, Smith S, Söderberg O, Strömblad S, et al
PLoS Biol. 2010 Nov;8(11):e1000521

Wrap53, a natural p53 antisense transcript required for p53 induction upon DNA damage.
Mahmoudi S, Henriksson S, Corcoran M, Méndez-Vidal C, Wiman K, Farnebo M
Mol. Cell 2009 Feb;33(4):462-71