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Karolinska Research Lectures: Wolf Reik

2014-10-1616:15 Nobel Forum, Nobels väg 1, SolnaCampus Solna

Karolinska Research Lectures at Nobel Forum: Wolf Reik, Head of the Epigenetics Programme, The Babraham Institute Cambridge, Cambridge, UK.

Epigenetic information in the mammalian genome is relatively stable in differentiated somatic cells in the adult body, but is reprogrammed on a genome-wide scale in germ cells and early embryos. Epigenetic reprogramming is conserved in all mammals and is tightly associated with the pluripotent state. It also limits the extent to which epigenetic information is inherited across generations (in contrast to plants which do not have large-scale epigenetic reprogramming in the germ line). In order to achieve pluripotency of stem cells it is probably important to erase pre-existing epigenetic memory. This memory is re-engaged when cells become primed for differentiation. We have recently proposed that epigenetic mechanisms can create diversity of transcriptional states, which helps with symmetry breaking during cell fate decisions and lineage commitment. We apply novel single cell methods in order to measure such epigenetic heterogeneity. 

Mer om Karolinska Research Lectures
I samband med Nobel Forums tillkomst 1993 startade Nobelförsamlingen och Karolinska Institutet föreläsningsserien "Karolinska research lectures". Gästföreläsare är världsledande forskare som också får träffa KI-forskare inom sina ämnesområden. Föreläsningarna pågår ungefär en timme och följs av informella diskussioner.

Karolinska Research Lectures hösten 2014 (pdf).

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