CPF research seminar
Positron Emission Tomography of Human Brain can Monitor cAMP Signaling and Neuroinflammation: Applications to Depression and Alzheimer´s Disease
Lecture by Dr Robert Innis from the NIMH
Briefly about Dr Innis and his work
Dr. Robert Innis is Chief of the Molecular Imaging Branch at NIMH. Dr. Innis received his MD and PhD degrees from Johns Hopkins, with his thesis work performed under the mentorship of Dr. Solomon Snyder. Dr. Innis then trained in psychiatry at Yale and later joined its faculty. During his 17 years at Yale, his work focused on studying receptors in the brain using radiolabeled probes.
His two most important accomplishments at Yale were: One, he discovered a radioligand to label the dopamine transporter, and this radioligand is now approved in the EU and USA to aid in the diagnosis of Parkinsons disease. Two, he used receptor imaging to indirectly measure dopamine released into the synapse. Using this technique, he showed that patients with schizophrenia have elevated dopamine release, which then induces psychotic symptoms.
Dr. Innis moved to the National Institute of Mental Health in 2001 and has worked with Dr. Victor Pike on both training and research. Drs. Innis and Pike have developed several new PET radioligands to image targets in brain. Dr. Innis will speak to us on two of these targets. The first is translocator protein (TSPO), a marker of inflammation in brain. The second is phosphodiesterase4 (PDE4), the major enzyme in brain to metabolize the second messenger cAMP.
More about his work at the CPF research seminar!