Ming Wai Lau Centre for Reparative Medicine
Ming Wai Lau Centre for Reparative Medicine is established to further accelerate research in stem cell biology, biomedical engineering, biotechnology, and regenerative medicine at KI.
Fredrik Lanner and Simon Elsässer's new publication in Nature Cell Biology
Fredrik Lanner and Simon Elsässer joined forces to identify the function of Polycomb Repressor Complex 2 (PRC2) as an epigenetic barrier in maintaining the separation of embryonic and extraembryonic lineages. In this study, the two laboratories elucidate how distinct cell types are established during early human development, which increase our understanding of human development and early pregnancy, and provide an avenue to study disease condition in cellular models.
Gonçalo Castelo-Branco's new publication in Developmental Cell
A team led by Gonçalo Castelo-Branco with researchers from Karolinska Institutet and Stockholm University found that oligodendrocytes, a cell type in the central nervous system known to be targeted in multiple sclerosis (MS), arise in brain during human development much earlier than mainly thought. The findings could be relevant for developing regenerative-based therapies for MS.
Gonçalo Castelo-Branco’s new publication in Science
Researchers at Yale University, in collaboration with the team led by Gonçalo Castelo-Branco, have developed a new technology, spatial-CUT&Tag, that gives precise information about the location of activated and inactivated genes in a specific tissue. The technology has a broad range of scientific and medical applications, and can provide important knowledge about the development of disease.
Simon Elsässer has been awarded the ERC Proof of Concept 2022 Grant
Simon Elsässer is one of the three research group leaders at KI who is awarded the European Research Council Proof of Concept (ERC PoC) 2022 grant. The grant will support his research project on hmqPro, and the work in securing IPR and commercialisation of his technology.
Sijie Chen’s research paper gets highlighted as front cover in Advanced Healthcare Materials
Sijie Chen Lab and their collaborators have designed and synthesized a series of cationic cyclometalated Iridium(III) complexes with aggregation-induced emission (AIE) properties. These phosphorescent agents can be utilized to stain both Gram-positive and Gram-negative bacteria and to inactivate the bacteria in a photodynamic process. This manuscript is highlighted as the front cover of Advanced Healthcare Materials, issue 24, 2021.
Zongli Zheng has a new publication in Journal of Thoracic Oncology
Half of advanced stage lung cancer patients can survive longer than seven years if their tumors are driven by ALK rearrangement and treated by ALK inhibitors, but the remaining half cannot. Zongli Zheng Lab has used deep RNA sequencing, conducted clinical and in vitro experiments to understand the reasons for the poor responses in the remaining half. The study revealed that intratumoral EML4-ALK isoforms may predict the efficacy of targeted therapy in ALK-rearranged NSCLC. Temporal changes of intratumoral fusion isoforms may result from differential selection pressures that a drug might have on one isoform over another. Future therapeutic approaches may be directed to treat alternative RNA splicing-rendered heterogeneity and tumor resistance.
MWLC Booklet 2021
Check out the MWLC 2021 Booklet which summarizes the research development of our 10 research teams from Sweden and Hong Kong, and their achievement highlights ranging from publications, research grants, patents, to awards. We also have corporate spin-off translating research outcome to vaccines delivery and therapeutics.
Inauguration of MWLC
On 7 October 2016, MWLC was inaugurated in Hong Kong Science Park. The officiating party included representatives of the Chinese and Hong Kong SAR governments, the Consul General of Sweden in Hong Kong and Macao, senior management of KI and Steering Group and management team of MWLC.
Visit of HRH Prince Carl Philip
HRH Prince Carl Philip of Sweden visited MWLC on 7 December as part of an official visit to Hong Kong. Our scientists showed the Prince and the Consul General Helena Storm to our lab facilities and experiments.
Visit of the President and Chair of the Board
President Ole Petter Ottersen and Chair of the Board of Karolinska Institutet Mikael Odenberg met with MWLC staff for the very first time on 19 December 2018. Our PIs presented ongoing research and demonstrated some of the techniques used in the lab.
Shaping the future of MWLC
MWLC together with the Consulate General of Sweden organized the reception "Moving forward together: Shaping the future of Ming Wai Lau Centre for Reparative Medicine" for representatives from the academia, industry and governmental bodies to learn more about MWLC and our ongoing activities.
For MWLC staff
KI-login required for information for MWLC staff only