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Fysiologföreningen presenterar: Professor Marco Celio

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2019-04-0416:00 Biomedicum hörsal 2 (D0351), Biomedicum, Solnavägen 9, entréplanCampus SolnaBiomedicum

Neuronal substrates of eye movement during REM sleep

Föreläsare:

Professor Marco Celio, Department of Medicine, University of Fribourg, Schweiz

Abstract:

Rapid eye movements are characteristic fo the emponymoous phase of sleep. Wherefrom stem the motor commands that underlie them remains an enigma. dr. Celio and colleagues have identified a cluster of Calbindin-D28K expressing neurons (Nucleus papilio, NPCalb), in the dorsal paragigantocellular nucleus, that is selectively active during REM sleep, and project to the three contralateral eye-muscle nuclei.

The firing of opto-tagged NPCalb neurons is augmented proor to the onset of eye movements (RMs) and their optogenetic activation initiates EMs selectively during REM sleep. Their genetic ablation or optogenetic silencing annhihilates or suppresses EMs. No such responses are elicited during either wakefulness or non-REM sleep.

This study provides the first evidence for a brainstem premotor command contributing to the control of EMs selectively during REM sleep in the mammalian brain.

Värd

Christian Broberger

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Christian Broberger
E-post: Christian.Broberger@ki.se

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FysiologiNeurovetenskap