What is life? lecture - Neuronal Migration and Brain Map Formation
Speaker: Pasko Rakic, Yale University, New Haven, CT, USA
Host: Hugo Lagercrantz
17.15 – 18 Discussion with participants
Pasko Rakic, MD, PhD - Dorys McConnell Duberg Professor of Neuroscience. Yale University, New Haven, CT. USA
Neuronal Migration and Brain Map Formation
The identity, synaptic connections and ultimately function of neurons during development and evolution of the cerebral cortex are defined by their position. Since cortical neurons are not generated locally, they acquire their areal, laminar and columnar positions by active, guided migration from multiple, increasingly distant sites of origin. Starting with our initial radial unit hypotheis, over the years, we have identified various genetic, molecular, cellular and environmental factors that enable this unique evolutionary achievement that culminates in human cerebral cortex as an organ of thought, but can also cause neuronal mal-positions that affect synaptic circuits underlying a variety of neuropsychiatric disorders.