Vessel Wall Signaling

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Projektledare Joy Roy


Joy Roy

Telefon: 851779355
Enhet: Kärlkirurgi



Johan Ekstrand

Telefon: 08-517 735 61
Enhet: Kärlkirurgi


Helen Sinabulya

Enhet: Kärlkirurgi

Homeostasis in the vessel wall is maintained by signaling between the different cell types and the matrix and recently also been shown to be affected by the flowing blood, also known as shear stress. Our aim is to identify the critical signaling mechanisms in physiological states and understand how they are affected during vascular injury. In particular, we are focusing on insulin‐like growth factor 1 and shear stress related signaling in smooth muscle cells and their role in vessel wall injury. We aim to identify target critical signaling pathways in order to attenuate atherosclerosis progression and complications for example plaque rupture and improve results after vascular surgery. We use in vitro cell culture models, small animal models and even clinical databases and patient samples to test our hypotheses