Pulmonary Hypertension for clinicians and researchers
on 5th April 4:45pm at the Faculty Club, Karolinska University Hospital Solna.
Our first speaker is Professor Vinicio de Jesus Perez from Stanford University Medical Center, who will present to us "Pulmonary Hypertension - a primer to clinician and vascular biologists".
Pulmonary arterial hypertension (PAH) is a devastating disease associated with small vessel obstruction and progressive right heart failure with a median survival of 3 years. While the etiology of PAH is unknown, the last 15 years have seen major discoveries that provide hope for future curative therapies. We will review the clinical manifestations and pathogenesis of pulmonary arterial hypertension, focusing on recent discoveries in genetics and cellular biology. We will also present research looking at how anomalies in endothelial cell and pericyte communication contributes to small vessel loss and development of PAH.
Our second speaker is Karin Lundmark, MD PhD from Karolinska Institutet and Lund University, who will tell us more about "Extracellular matrix and growth factor regulation in pulmonary hypertension".
Extracellular matrix proteoglycans may be of importance for the pathogenesis of pulmonary arterial hypertension due to their ability to bind growth factors and cytokines. Depending of their localization in the extracellular space they may either sequester growth factors, and thereby restrict their activity, or present growth factors to cell-surface receptors. Novel findings from animal models as well as human data will be discussed.
Coffee, tea and refreshments will be served before the mini-symposium.
After the presentations, we will continue the discussion with beer, wine, soft drinks and snacks.
You can register either via KI survey, email to KIRCfirstname.lastname@example.org or via Facebook event.