CRISPR-baserad identifiering av läkmedelsmål vid cancer och autoimmunitet – Forskargrupp Fredrik Wermeling

Publikationer

Utvalda publikationer

• Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857

  Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2.

  Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmström V; Phan AT; Wermeling F
• Article: CANCER RESEARCH. 2022;82(1):36-45

  CRISPR/Cas9-Induced DNA Damage Enriches for Mutations in a p53-Linked Interactome: Implications for CRISPR-Based Therapies.

  Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
• Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2021;19:5360-5370

  A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.

  Shen Y; Jiang L; Iyer VS; Raposo B; Dubnovitsky A; Boddul SV; Kasza Z; Wermeling F
• Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087

  In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors.

  Boddul SV; Sharma RK; Dubnovitsky A; Raposo B; Gerstner C; Shen Y; Iyer VS; Kasza Z; Kwok WW; Winkler AR; Klareskog L; Malmström V; Bettini M; Wermeling F
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):3103-3113

  IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.

  Panda SK; Wigerblad G; Jiang L; Jiménez-Andrade Y; Iyer VS; Shen Y; Boddul SV; Guerreiro-Cacais AO; Raposo B; Kasza Z; Wermeling F
• Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:2237-2246

  Designing custom CRISPR libraries for hypothesis-driven drug target discovery.

  Iyer VS; Jiang L; Shen Y; Boddul SV; Panda SK; Kasza Z; Schmierer B; Wermeling F
• Article: BIOINFORMATICS. 2017;33(7):1099-1100

  Green listed-a CRISPR screen tool.

  Panda SK; Boddul SV; Jiménez-Andrade GY; Jiang L; Kasza Z; Fernandez-Ricaud L; Wermeling F
• Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13487-13491

  Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling.

  Wermeling F; Anthony RM; Brombacher F; Ravetch JV
• Article: NATURE. 2011;475(7354):110-113

  Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

  Anthony RM; Kobayashi T; Wermeling F; Ravetch JV
• Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):943-952

  Invariant NKT cells limit activation of autoreactive CD1d-positive B cells.

  Wermeling F; Lind SM; Jordö ED; Cardell SL; Karlsson MCI

Finansiering

Medlemmar och kontakt

Gruppledare

• 

  Fredrik Wermeling

  Senior Forskare | Docent

  E-postadress fredrik.wermeling@ki.se

Alla medlemmar i gruppen

• 

  Zsolt Kasza

  Laboratorieansvarig

  E-postadress zsolt.kasza@ki.se
• Zhaojun Li

  Doktorand

  E-postadress zhaojun.li@ki.se
• 

  Yunbing Shen

  Doktorand

  E-postadress yunbing.shen@ki.se
• 

  Fredrik Wermeling

  Senior Forskare | Docent

  E-postadress fredrik.wermeling@ki.se