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["no.","REPORTING QUALITY"]
[null,"Test item and controls"]
[1,"The chemical name or other identification, such as CAS-number, of the test item was given."]
[2,"The purity of the test item was stated or is traceable according to information given regarding manufacturer and lot/batch number. In case of mixtures, the composition of different constituents was stated."]
[3,"The solvent (vehicle) was described."]
[4,"It was stated that a solvent (vehicle) control was included."]
[null,"Physicochemical properties of the test item"]
[5,"The size of the test item was stated."]
[6,"The size distribution of the test item was stated."]
[7,"The crystallinity of the test item was stated."]
[8,"The shape of the test item was stated."]
[9,"The surface chemistry of the test item was stated."]
[10,"The surface charge of the test item was stated."]
[11," The surface area of the test item was stated."]
[12,"The water solubility or dissolution rate of the test item was described."]
[13,"The agglomeration/aggregation of the test item was stated."]
[14,"The sample preparation methodology of the test item was stated."]
[15,"The dispersion stability of the test item was stated."]
[16,"The transformation of the test item or temporal changes of its physicochemical properties has been described."]
[null,"Test System"]
[17,"The test system (e.g. cell line / cells/ tissue / organ / embryo / sub-cellular fractions) was described."]
[18,"The source of the test system was stated."]
[19,"The metabolic competence, i.e. competence of the test system to metabolize the test compound into an active metabolite was described."]
[20,"The number of cell passages of the cell line used was stated. (Remove this criterion if the study was not conducted in a cell line.)"]
[21,"Composition of media was described, including use of serum, antibiotics, etc."]
[22,"Incubation temperature, humidity, and CO2 concentration were described."]
[23,"Measures taken for avoiding or screening for contamination by mycoplasma, bacteria, fungi and virus were described. "]
[24,"Measures taken to avoid or address the test item interference with the test method were described."]
[null,"Administration of test compound"]
[25,"The administered dose levels or concentrations were stated."]
[26,"Cell density or number of cells used during treatment was described. (Remove this criterion if the study was not conducted in a cell line.)"]
[27,"The duration of treatment was stated. "]
[28,"The number of replicates per dose level/concentration or the number of times the experiment was repeated was stated."]
[29,"The cellular uptake or distribution of the test item was measured."]
[null,"Data collection and analysis"]
[30,"The tests and/or analytical methods used were sufficiently described to allow for evaluation of reliability of results."]
[31,"The dose metrics used were appropriately reported."]
[32,"The time points for data collection were stated."]
[33,"It was stated that the effect of the test compound on cytotoxicity was measured."]
[34,"All results were clearly presented. "]
[35,"The statistical methods and software used were described."]
[null,"Funding and competing interests "]
[36,"The funding sources for the study were stated."]
[37,"Any competing interests were disclosed or it was explicitly stated that the authors did not have any competing interests."]
[null,"Other"]
[38,"Was all information that is indispensable for evaluating the reliability of data given? This includes information on the test compound and controls, test system, study design or study performance. For example: delivery form; viscosity; dustiness; labelling information. "]
[null,"METHODOLOGICAL QUALITY"]
[null,"Test item and controls"]
[1,"The test item or mixture was unlikely to contain any impurities that may significantly have affected the results of the study."]
[2,"A dispersion of the test item was created by appropriate sample preparation method."]
[3,"The transformation of the test item or temporal changes of its physiochemical properties is not expected to affect the result."]
[4,"An appropriate solvent (vehicle) was used that is not expected to interfere with the results of the study at the concentration used. "]
[5,"A solvent (vehicle) control was included. "]
[6,"The dispersant/stabilizer used is not expected to interfere with the results of the study."]
[7,"An appropriate positive control was included, and the expected result was observed from this treatment."]
[null,"Test System"]
[8,"A reliable and sensitive test system (cell line / cells / tissue / organ /embryo / sub-cellular fractions) with metabolic competence, if relevant, was used for investigating the test item and endpoints."]
[9,"Conditions for cultivation and/or maintenance of the cell line / cells / tissue / organ /embryo (incubation temperature, humidity, CO2 concentration, media used, number of cell passages, control of contamination) were appropriate."]
[null,"Administration of the test item"]
[10,"The duration of exposure was suitable for the test system and investigated endpoints."]
[11,"The concentrations used were suitable for the test system and investigated endpoints."]
[12,"The test conditions during and after exposure to the test compound were suitable (media and serum used, cell density, incubation temperature, humidity, CO2 concentration)."]
[null,"Data collection and analysis"]
[13,"Reliable and sensitive tests and/or analytical methods were used for investigating the endpoints."]
[14,"The test item is not expected to interfere with the test method so as to affect the study result."]
[15,"Sufficient numbers of replicates or repetitions of the experiment were used to generate reliable and valid results."]
[16,"Measurements were collected at suitable time points in order to generate sensitive, valid and reliable data."]
[17,"Cytotoxicity was measured and the test compound did not cause cytotoxicity that significantly affected the results."]
[18,"The statistical methods were clearly described and do not seem inappropriate, unusual or unfamiliar. "]
[null,"Other"]
[19,"Are there any other aspects of study design, performance or reporting that influence reliability? "]
[null,"RELEVANCE"]
[1,"The identity of the tested substance"]
[2,"The test system used"]
[3,"The endpoint studied"]
[4,"The concentrations used "]