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["no.","REPORTING QUALITY"]
[null,"Test compound and controls"]
[1,"The chemical name or other identification, such as CAS-number, of the test compound was given."]
[2,"The purity of the test compound was stated or is traceable according to information given regarding manufacturer and lot/batch number. In case of mixtures, the composition of different constituents was stated."]
[3,"The solubility of the test compound was described."]
[4,"The solvent (vehicle) was described."]
[5,"It was stated that a solvent (vehicle) control was included."]
[null,"Test System"]
[6,"The test system (e.g., cell line / cells/ tissue / organ / embryo / sub-cellular fractions) was described."]
[7,"The source of the test system was stated."]
[8,"The metabolic competence, i.e., competence of the test system to metabolize the test compound into an active metabolite was described."]
[9,"The number of cell passages of the cell line used, was stated. \n(Remove this criterion if the study was not conducted in a cell line.)"]
[10,"Composition of media was described, including use of serum, antibiotics, etc."]
[11,"Incubation temperature, humidity, and CO2 concentration were described."]
[12,"Measures taken for avoiding or screening for contamination by mycoplasma, bacteria, fungi and virus were described. "]
[null,"Administration of test compound"]
[13,"The administered dose levels or concentrations were stated."]
[14,"Cell density or number of cells used during treatment was described.\n(Remove this criterion if the study was not conducted in a cell line.)"]
[15,"The duration of treatment was stated. "]
[16,"The number of replicates per dose level/concentration or the number of times the experiment was repeated was stated."]
[null,"Data collection and analysis"]
[17,"The tests and/or analytical methods used were sufficiently described to allow for evaluation of reliability of results."]
[18,"The time points for data collection were stated."]
[19,"It was stated that the effect of the test compound on cytotoxicity was measured."]
[20,"All results were clearly presented. "]
[21,"The statistical methods and software used were described."]
[null,"Funding and competing interests "]
[22,"The funding sources for the study were stated."]
[23,"Any competing interests were disclosed or it was explicitly stated that the authors did not have any competing interests."]
[null,"Other"]
[24,"Was all information that is indispensable for evaluating the reliability of data given? This includes information on the test compound and controls, test system, study design or study performance."]
[null,"METHODOLOGICAL QUALITY"]
[null,"Test compound and controls"]
[1,"The test compound or mixture was unlikely to contain any impurities that may significantly have affected the results of the study."]
[2,"It was likely that the test compound was soluble at the concentrations used."]
[3,"An appropriate solvent (vehicle) was used that is not expected to interfere with the results of the study at the concentration used. "]
[4,"A solvent (vehicle) control was included."]
[5,"An appropriate positive control was included, and the expected result was observed from this treatment."]
[null,"Test System"]
[6,"A reliable and sensitive test system (e.g., cell line / cells/ tissue / organ / embryo / sub-cellular fractions) with metabolic competence, if relevant, was used for investigating the test compound and endpoints."]
[7,"Conditions for cultivation and/or maintenance of the cell line / cells / tissue / organ /embryo / sub-cellular fractions (incubation temperature, humidity, CO2 concentration, media used, number of cell passages, control of contamination) were appropriate."]
[null,"Administration of the test compound"]
[8,"The duration of exposure was suitable for the test system and investigated endpoints."]
[9,"The concentrations used were suitable for the test system and investigated endpoints."]
[10,"The test conditions during and after exposure to the test compound were suitable (media and serum used, cell density, incubation temperature, humidity, CO2 concentration)."]
[null,"Data collection and analysis"]
[11,"Reliable and sensitive tests and/or analytical methods were used for investigating the endpoints."]
[12,"Sufficient numbers of replicates or repetitions of the experiment were used to generate reliable and valid results."]
[13,"Measurements were collected at suitable time points in order to generate sensitive, valid and reliable data."]
[14,"Cytotoxicity was measured and the test compound did not cause cytotoxicity that significantly affected the results."]
[15,"The statistical methods were clearly described and do not seem inappropriate, unusual or unfamiliar. "]
[null,"Other"]
[16,"Are there any other aspects of study design, performance or reporting that influence reliability? "]
[null,"RELEVANCE"]
[1,"The identity of the tested substance"]
[2,"The test system used"]
[3,"The endpoint studied"]
[4,"The concentrations used "]