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["No.","RELIABILITY"]
[null,"Test setup"]
[1,"Is a guideline method (e.g., OECD/ISO) or modified guideline used? (of minor importance for study reliability)"]
[2,"Is the test performed under GLP conditions? (of minor importance for study reliability)"]
[3,"If applicable, are validity criteria fulfilled (e.g. control survival, growth)?"]
[4,"Are appropriate controls performed (e.g. solvent control, negative and positive control)?"]
[null,"Test compound"]
[5,"Is the test substance identified clearly with name or CAS-number? Are test results reported for the appropriate compound?"]
[6,"Is the purity of the test substance reported? Or, is the source of the test substance trustworthy?  "]
[7,"If a formulation is used or if impurities are present: Do other ingredients in the formulation exert an effect? Is the amount of test substance in the formulation known?"]
[null,"Test organism"]
[8,"Are the organisms well described (e.g. scientific name, weight, length, growth, age/life stage, strain/clone, sex, if appropriate)?"]
[9,"Are the test organisms from a trustworthy source and acclimatized to test conditions? Have the organisms not been pre-exposed to test compound or other unintended stressors?"]
[null,"Exposure conditions"]
[10,"Is the experimental system appropriate for the test substance, taking into account its physico-chemical characteristics?"]
[11,"Is the experimental system appropriate for the test organism (e.g., choice of medium or test water, feeding, water characteristics, temperature, light/dark conditions, pH, oxygen content)? Have conditions been stable during the test?"]
[12,"Were exposure concentrations below the limit of water solubility (taking the use of a solvent into account)? If a solvent is used, is the solvent within the appropriate range and is a solvent control included?"]
[13,"Is a correct spacing between exposure concentrations applied?"]
[14,"Is the exposure duration defined?"]
[15,"Are chemical analyses adequate to verify concentrations of the test substance over the duration of the study? "]
[16,"Is the biomass loading of the organisms in the test system within the appropriate range (e.g. < 1 g/L)?"]
[null,"Statistical design and biological response"]
[17,"Is a sufficient number of replicates used? Is a sufficient number of organisms per replicate used for all controls and test concentrations?"]
[18,"Are appropriate statistical methods used?"]
[19,"Is a concentration-response curve observed? Is the response statistically significant?"]
[20,"Are sufficient data available to check the calculation of endpoints and (if applicable)  validity criteria (e.g., control data, concentration-response curves)?"]
[]
[null,"BIOLOGICAL AND EXPOSURE RELEVANCE"]
[1,"Is the species tested relevant for the compartment under evaluation?"]
[2,"Are the organisms tested relevant for the tested substance?"]
[3,"Are the reported endpoints appropriate for the regulatory purpose?"]
[4,"Are the reported endpoints appropriate for the investigated effects or the mode of action of the test substance?"]
[5,"Is the effect relevant on a population level?"]
[6,"Are appropriate life stages studied?"]
[7,"Is the magnitude of effect statistically significant and biologically relevant for the regulatory purpose (e.g., EC10, EC50)?"]
[8,"Are the experimental conditions relevant for the tested species?"]
[9,"Is the exposure duration relevant and appropriate for the studied endpoints and species?"]
[10,"If recovery is studied, is this relevant for the framework for which the study is evaluated?"]
[11,"In case of a formulation, other mixture, salts, or transformation products, is the substance tested representative and relevant for the substance being assessed? "]
[12,"Is the tested exposure scenario relevant for the substance?"]
[13,"Is the tested exposure scenario relevant for the species?"]