MEB-seminarium: "Computational adventures with large biomedical datasets"
Talare: Andrey Rzhetsky, Professor, Department of Medicine, Section of Genetic Medicine, University of Chicago; Director, Conte Center for Neuropsychiatric Genomics, University of Chicago
Focusing on autism, bipolar disorder and schizophrenia, my talk will touch the following questions. How understanding of genetics and epidemiology of disease can be advanced through modeling and computational analysis of very large and heterogeneous datasets? What are the bottlenecks in analysis of complex human maladies? How can we model and compute over multiple data types to narrow hypotheses about genetic causes of disease? How collaborations across multiple fields of science can bring translational results to initially purely academic studies?
In particular, I will outline how large-scale clinical record data and legacy GWAS and linkage results can be used for comparison of competing genetic models for complex phenotypes, with examples in neuropsychiatric disorders.Contact person: Patrick Sullivan