MBB Seminar: Prof. Andrea Mattevi
Title: On the molecular mechanisms of chromatin modification
Prof. Andrea Mattevi's research involves the investigation of medically relevant enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is, however, complemented by other approaches such as site-directed mutagenesis, analysis of enzyme kinetics and computational chemistry. He will be presenting his recent research to reveal the molecular details – mostly in terms of protein/protein and protein/DNA interactions – of the assembly and recognition of Lysine-specific demethylase (LSD1)-CoREST1 in complex with the nucleosome.