Föreläsningar och seminarier

Quadruplex formation on linear and supercoiled DNA

2015-09-1110:00 Konf rum “Cellen” Plan 4, Hiss E Novum, Hälsovägen 7-9 Campus Flemingsberg

"Quadruplex formation on linear and supercoiled DNA"

Professor Keith R. Fox
Centre for Biological Sciences, University of Southampton, Southampton

Compounds that bind to DNA in a sequence specific fashion have potential for artificially controlling gene expression and may be used as anticancer or antiviral agents. 

Professor Fox research concerns the sequence specific recognition of DNA by small molecules, oligonucleotides and proteins, and the formation of unusual DNA structures like triplexes and quadruplexes. 

He has been involved in the development of several nucleotide analogues, which are designed to form stable triplexes under physiological conditions. Using a combination of these they demonstrated the first example of four base-pair recognition of a DNA sequence by a triplex-forming oligonucleotide at pH 7. Inclusion of such modified nucleotides not only greatly enhances triplex stability, but also increases the affinity for related sequences.

Contact person: Edvard Smith